PMID- 31060187
OWN - NLM
STAT- MEDLINE
DCOM- 20190814
LR  - 20190814
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 47
IP  - 4
DP  - 2019 Apr 24
TI  - [Efficacy and safety of transthoracic echocardiography-guided percutaneous 
      intramyocardial septal radiofrequency ablation for the treatment of patients with 
      obstructive hypertrophic cardiomyopathy].
PG  - 284-290
LID - 10.3760/cma.j.issn.0253-3758.2019.04.005 [doi]
AB  - Objective: To investigate the safety and efficacy of transthoracic 
      echocardiography-guided percutaneous intramyocardial septal radiofrequency 
      ablation (PIMSRA) in patients with hypertrophic obstructive cardiomyopathy 
      (HOCM). Methods: Nine HOCM patients with interventricular septal thickness >/=15 mm 
      and </=25 mm who were treated with PIMSRA between October 2016 to March 2017 in the 
      Hypertrophic Cardiomyopathy Center of Xijing Hospital of Air Force Military 
      Medical University were enrolled,and the clinical data were retrospectively 
      analyzed.Interventricular septum thickness, left ventricular outflow tract 
      diameter and maximum gradient were measured by transthoracic echocardiography 
      immediately after procedure, at 1 month, 3 months and 6 months after 
      operation.Symptoms and New York Heart Association (NYHA) functional class were 
      assessed, and provoked left ventricular outflow tract gradient and exercise time 
      were measured after 6 months. Results: The anterior interventricular septum 
      ((21.5+/-2.6) mm vs. (24.7+/-2.7) mm, P<0.05) and posterior interventricular septum 
      (21.1+/-2.5) mm vs. (22.6+/-3.3) mm, P<0.05) were significantly increased,left 
      ventricular outflow tract diameter was widened ((8.2+/-3.4) mm vs. (4.8+/-2.2) mm, 
      P<0.05), left ventricular outflow tract gradient ((26.8+/-19.6) mmHg (1 mmHg=0.133 
      kPa) vs. (83.3+/-32.4) mmHg, P<0.05) and mitral regurgitation (2.0+/-1.9) ml vs. 
      (3.2+/-3.0) ml, P<0.05) were significantly decreased immediately after ablation 
      compared with pre-operation values. Anterior interventricular septum, posterior 
      interventricular septum and left ventricular outflow tract gradient further 
      decreased after 1 month ((17.5+/-2.0) mm vs. (24.7+/-2.7) mm, P<0.05; (16.9+/-2.1) mm 
      vs. (22.6+/-3.3) mm, P<0.05; (11.6+/-4.0) mmHg vs. (26.8+/-19.6) mmHg, P<0.05, 
      respectively) compared with values immediately after ablation. Anterior 
      interventricular septum and posterior interventricular septum decreased after 3 
      and 6 months ((14.8+/-1.7) mm and (13.4+/-2.0) mm vs. (17.5+/-2.0) mm, all P<0.05; 
      (12.9+/-1.9) mm and (12.3+/-2.4) mm vs. (16.9+/-2.1) mm, all P<0.05, respectively) 
      compared with values at 1 month after ablation.There were no significantly 
      difference in left ventricular outflow tract gradient at 3 and 6 months post 
      procedure compared with 1 month after ablation (all P>0.05). Compared with 
      pre-operation, provoked left ventricular outflow tract gradient decreased 
      ((25.5+/-11.4) mmHg vs. (147.8+/-58.0) mmHg, P<0.01), and total exercise time 
      increased ((9.3+/-1.6) minutes vs. (6.7+/-1.6) minutes, P=0.03) at 6 months after 
      operation.The symptoms were disappeared in 5 patients. There were 2 cases with 
      NYHA class Ⅱ and 7 cases with NYHA class Ⅲ before operation,while there were 6 
      patients with NYHA classⅠ and 3 patients with NYHA class Ⅱ at 6 months after 
      operation (P<0.01). Conclusion: Transthoracic echocardiography-guided PIMSRA is a 
      safe and effective new treatment approach for patients with obstructive 
      hypertrophic cardiomyopathy.
FAU - Liu, L W
AU  - Liu LW
AD  - Hypertrophic Cardiomyopathy Center of Xijing Hospital of Air Force Medical 
      University, Multi-disciplinary Consultation Center of Hypertrophic Cardiomyopathy 
      of Shaanxi Province, Ultrasound Department of XijingHospital of Air Force Medical 
      University, Xi'an 710032, China.
FAU - Zuo, L
AU  - Zuo L
AD  - Hypertrophic Cardiomyopathy Center of Xijing Hospital of Air Force Medical 
      University, Multi-disciplinary Consultation Center of Hypertrophic Cardiomyopathy 
      of Shaanxi Province, Ultrasound Department of XijingHospital of Air Force Medical 
      University, Xi'an 710032, China.
FAU - Zhou, M Y
AU  - Zhou MY
AD  - Hypertrophic Cardiomyopathy Center of Xijing Hospital of Air Force Medical 
      University, Multi-disciplinary Consultation Center of Hypertrophic Cardiomyopathy 
      of Shaanxi Province, Ultrasound Department of XijingHospital of Air Force Medical 
      University, Xi'an 710032, China.
FAU - Li, J
AU  - Li J
AD  - Hypertrophic Cardiomyopathy Center of Xijing Hospital of Air Force Medical 
      University, Multi-disciplinary Consultation Center of Hypertrophic Cardiomyopathy 
      of Shaanxi Province, Ultrasound Department of XijingHospital of Air Force Medical 
      University, Xi'an 710032, China.
FAU - Zhou, X D
AU  - Zhou XD
AD  - Hypertrophic Cardiomyopathy Center of Xijing Hospital of Air Force Medical 
      University, Multi-disciplinary Consultation Center of Hypertrophic Cardiomyopathy 
      of Shaanxi Province, Ultrasound Department of XijingHospital of Air Force Medical 
      University, Xi'an 710032, China.
FAU - He, G B
AU  - He GB
AD  - Hypertrophic Cardiomyopathy Center of Xijing Hospital of Air Force Medical 
      University, Multi-disciplinary Consultation Center of Hypertrophic Cardiomyopathy 
      of Shaanxi Province, Ultrasound Department of XijingHospital of Air Force Medical 
      University, Xi'an 710032, China.
FAU - Zhang, J
AU  - Zhang J
AD  - Hypertrophic Cardiomyopathy Center of Xijing Hospital of Air Force Medical 
      University, Multi-disciplinary Consultation Center of Hypertrophic Cardiomyopathy 
      of Shaanxi Province, Ultrasound Department of XijingHospital of Air Force Medical 
      University, Xi'an 710032, China.
FAU - Zhang, J Z
AU  - Zhang JZ
AD  - Cardiac Surgery Department of Xijing Hospital of Air Force Medical University, 
      Xi'an 710032, China.
FAU - Liu, B
AU  - Liu B
AD  - Cardiology Department of Xijing Hospital of Air Force Medical University, Xi'an 
      710032, China.
FAU - Yang, J
AU  - Yang J
AD  - Cardiac Surgery Department of Xijing Hospital of Air Force Medical University, 
      Xi'an 710032, China.
FAU - Xu, B
AU  - Xu B
AD  - Cardiac Surgery Department of Xijing Hospital of Air Force Medical University, 
      Xi'an 710032, China.
LA  - chi
GR  - 2014DFA31980/International Science and Technology Cooperation Program of China/
GR  - 81601498, 81671693/National Natural Science Fundation of China/
GR  - 2017ZDXM-SF-058/Shaanxi Provincial Key Projects/
GR  - 417432A/Xijing Funded Project for New Technologies and Services/
GR  - 2014KCT-20/Key Science and Technology Innovation Team Project of Shaanxi 
      Province/
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
MH  - *Cardiomyopathy, Hypertrophic/therapy
MH  - *Catheter Ablation
MH  - Echocardiography
MH  - Humans
MH  - *Radiofrequency Ablation
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Ablation techniques
OT  - Cardiomyopathy, hypertrophic
OT  - Treatment outcome
EDAT- 2019/05/08 06:00
MHDA- 2019/08/15 06:00
CRDT- 2019/05/07 06:00
PHST- 2019/05/07 06:00 [entrez]
PHST- 2019/05/08 06:00 [pubmed]
PHST- 2019/08/15 06:00 [medline]
AID - 10.3760/cma.j.issn.0253-3758.2019.04.005 [doi]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Apr 24;47(4):284-290. doi: 
      10.3760/cma.j.issn.0253-3758.2019.04.005.