PMID- 31061878
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 7
IP  - 5
DP  - 2019 May
TI  - Endoscopic submucosal dissection in management of colorectal tumors near or 
      involving a diverticulum: a retrospective case series.
PG  - E664-E671
LID - 10.1055/a-0848-8048 [doi]
AB  - Background and study aims  Surgery is the standard treatment for colon tumors 
      associated with diverticulum. U se of endoscopic submucosal dissection (ESD) to 
      treat such tumors is controversial. The aim of this study was to assess the 
      safety and feasibility of ESD in treating superficial colorectal tumors situated 
      near or involving diverticulum. Patients and methods  Consecutive patients from 
      two referral centers who had colorectal tumors near or involving diverticulum 
      treated by ESD were retrospectively studied. Clinicopathological characteristics 
      and clinical outcomes were analyzed. Results  Of the 12 patients studied, six had 
      tumors near diverticulum and six had tumors involving diverticulum. The overall 
      en-bloc R0 resection rate, median tumor size and procedure time were 67 %, 
      26.5 mm (range, 15 - 80 mm) and 110 minutes (range, 50 - 220 minutes), 
      respectively. For tumors near diverticulum group, the en-bloc R0 resection rate 
      was 100 % and no adverse events (AEs) or residual/recurrent tumors were observed. 
      In contrast, for intradiverticular tumors group, the en-bloc R0 resection rate 
      was low at 33 %, and one AE (perforation) was observed. The diverticula were 
      >/= 6 mm in diameter in the patients with incomplete resection. However, all but 
      one diverticulum was unrecognized before ESD. Two residual tumors were detected 
      at the 12-month surveillance and one required surgery. Conclusions  This case 
      series indicates that ESD is safe and feasible for treating colorectal tumors 
      near a diverticulum and might be feasible for tumors involving a diverticulum 
      smaller than 6 mm. Selection for smaller diverticulum size may contribute to 
      higher en-bloc R0 resection rates.
FAU - Jimenez-Garcia, Victoria Alejandra
AU  - Jimenez-Garcia VA
AD  - National Cancer Center Hospital, Endoscopy Division, Tokyo, Japan.
FAU - Yamada, Masayoshi
AU  - Yamada M
AD  - National Cancer Center Hospital, Endoscopy Division, Tokyo, Japan.
FAU - Ikematsu, Hiroaki
AU  - Ikematsu H
AD  - National Cancer Center Hospital East, Division of Endoscopy and Gastrointestinal 
      Oncology, Kashiwa, Japan.
FAU - Takamaru, Hiroyuki
AU  - Takamaru H
AD  - National Cancer Center Hospital, Endoscopy Division, Tokyo, Japan.
FAU - Abe, Seiichiro
AU  - Abe S
AD  - National Cancer Center Hospital, Endoscopy Division, Tokyo, Japan.
FAU - Sakamoto, Taku
AU  - Sakamoto T
AD  - National Cancer Center Hospital, Endoscopy Division, Tokyo, Japan.
FAU - Nakajima, Takeshi
AU  - Nakajima T
AD  - National Cancer Center Hospital, Endoscopy Division, Tokyo, Japan.
FAU - Matsuda, Takahisa
AU  - Matsuda T
AD  - National Cancer Center Hospital, Endoscopy Division, Tokyo, Japan.
FAU - Saito, Yutaka
AU  - Saito Y
AD  - National Cancer Center Hospital, Endoscopy Division, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190503
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC6499619
COIS- Competing interests None
EDAT- 2019/05/08 06:00
MHDA- 2019/05/08 06:01
PMCR- 2019/05/01
CRDT- 2019/05/08 06:00
PHST- 2018/06/29 00:00 [received]
PHST- 2018/12/27 00:00 [accepted]
PHST- 2019/05/08 06:00 [entrez]
PHST- 2019/05/08 06:00 [pubmed]
PHST- 2019/05/08 06:01 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - 10.1055/a-0848-8048 [doi]
PST - ppublish
SO  - Endosc Int Open. 2019 May;7(5):E664-E671. doi: 10.1055/a-0848-8048. Epub 2019 May 
      3.