PMID- 31062413
OWN - NLM
STAT- MEDLINE
DCOM- 20200918
LR  - 20200918
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 120
IP  - 9
DP  - 2019 Sep
TI  - Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and 
      glycolysis in laryngeal squamous cell carcinoma cells.
PG  - 15874-15882
LID - 10.1002/jcb.28858 [doi]
AB  - Forkhead box (FOX) proteins are a large family of transcription factors that are 
      involved in multiple biological processes. FOXJ1, a member of the FOX family, has 
      been found to participate in tumorigenesis. However, the role of FOXJ1 in 
      laryngeal squamous cell carcinoma (LSCC) is still unclear. The aim of the present 
      study was to explore the potential roles of FOXJ1 in LSCC. Our results showed 
      that FOXJ1 was overexpressed in LSCC tissues and cell lines. Then the small 
      interfering RNA targeting FOXJ1 (FOXJ1-siRNA) or control siRNA was transfected 
      into TU-177 and AMC-HN-8 cells to knockdown FOXJ1. Cell Counting Kit-8 assay 
      showed that knockdown of FOXJ1 inhibited the proliferation of LSCC cells. 
      Transwell assay revealed that FOXJ1-siRNA-transfected cells showed significant 
      reduction in cell migration and invasion compared to the cells transfected with 
      control siRNA. FOXJ1 knockdown suppressed glycolysis in LSCC cells, which was 
      illustrated by the reduced glucose consumption and lactate production. In 
      addition, FOXJ1 knockdown inhibited the activation of the Wnt/beta-catenin pathway, 
      and the LiCl treatment mitigated the inhibitory effects of FOXJ1-siRNA on cell 
      proliferation, migration, invasion, and glycolysis. These findings indicated that 
      FOXJ1-siRNA executed its functions via suppressing the activation of the 
      Wnt/beta-catenin pathway.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Liu, Lifeng
AU  - Liu L
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated 
      Hospital, Xi'an Jiaotong University, Xi'an, China.
FAU - Zhang, Pengfei
AU  - Zhang P
AUID- ORCID: 0000-0002-0084-425X
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated 
      Hospital, Xi'an Jiaotong University, Xi'an, China.
FAU - Shao, Yuan
AU  - Shao Y
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated 
      Hospital, Xi'an Jiaotong University, Xi'an, China.
FAU - Quan, Fang
AU  - Quan F
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated 
      Hospital, Xi'an Jiaotong University, Xi'an, China.
FAU - Li, Huajing
AU  - Li H
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated 
      Hospital, Xi'an Jiaotong University, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20190506
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (FOXJ1 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - G4962QA067 (Lithium Chloride)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Cell Line, Tumor
MH  - Cell Movement/drug effects
MH  - Cell Survival/drug effects
MH  - Female
MH  - Forkhead Transcription Factors/*genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Glycolysis/drug effects
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - Lithium Chloride/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Up-Regulation
MH  - Wnt Signaling Pathway
OTO - NOTNLM
OT  - FOXJ1
OT  - Wnt/beta-catenin pathway
OT  - forkhead box proteins
OT  - glycolysis
OT  - laryngeal squamous cell carcinoma
EDAT- 2019/05/08 06:00
MHDA- 2020/09/20 06:00
CRDT- 2019/05/08 06:00
PHST- 2018/12/05 00:00 [received]
PHST- 2019/02/11 00:00 [revised]
PHST- 2019/02/14 00:00 [accepted]
PHST- 2019/05/08 06:00 [pubmed]
PHST- 2020/09/20 06:00 [medline]
PHST- 2019/05/08 06:00 [entrez]
AID - 10.1002/jcb.28858 [doi]
PST - ppublish
SO  - J Cell Biochem. 2019 Sep;120(9):15874-15882. doi: 10.1002/jcb.28858. Epub 2019 
      May 6.