PMID- 31064097
OWN - NLM
STAT- MEDLINE
DCOM- 20190820
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 9
DP  - 2019 May 6
TI  - Monocyte Chemoattractant Protein-1, a Possible Biomarker of Multiorgan Failure 
      and Mortality in Ventilator-Associated Pneumonia.
LID - 10.3390/ijms20092218 [doi]
LID - 2218
AB  - Ventilator-associated pneumonia (VAP) leads to increased patients' mortality and 
      medical expenditure. Monocyte chemoattractant protein-1 (MCP-1) plays a role in 
      the pathogenesis of lung inflammation and infection. Therefore, the plasma 
      concentration of MCP-1 was assessed and correlated with the clinical course in 
      VAP patients. This retrospective observational study recruited 45 healthy 
      volunteers, 12 non-VAP subjects, and 30 VAP patients. The diagnostic criteria for 
      VAP were based on the American Thoracic Society guidelines, and the level of 
      plasma MCP-1 was determined by ELISA. Plasma MCP-1 concentration was 
      significantly elevated in the acute stage in VAP patients when compared with the 
      control (p < 0.0001) and non-VAP patient groups (p = 0.0006). Subsequently, it 
      was remarkably decreased following antibiotic treatment. Moreover, plasma MCP-1 
      concentration was positively correlated with indices of pulmonary dysfunction, 
      including the lung injury score (p = 0.02) and the oxygenation index (p = 0.02). 
      When patients with VAP developed adult respiratory distress syndrome (ARDS), 
      their plasma MCP-1 concentrations were significantly higher than those of 
      patients who did not develop ARDS (p = 0.04). Moreover, plasma MCP-1 
      concentration was highly correlated with organ failure scores, including 
      simplified acute physiology score II (SAPS II, p < 0.0001), sequential organ 
      failure assessment score (SOFA, p < 0.0001), organ dysfunctions and/or infection 
      (ODIN, p < 0.0001), predisposition, insult response and organ dysfunction (PIRO, 
      p = 0.005), and immunodeficiency, blood pressure, multilobular infiltrates on 
      chest radiograph, platelets and hospitalization 10 days before onset of VAP 
      (IBMP-10, p = 0.004). Our results demonstrate that plasma MCP-1 is an excellent 
      marker for recognizing VAP when the cut-off level is set to 347.18 ng/mL (area 
      under the curve (AUC) = 0.936, 95% CI = 0.863-0.977). In conclusion, MCP-1 not 
      only could be a biological marker related to pulmonary dysfunction, organ 
      failure, and mortality in patients with VAP, but also could be used for early 
      recognition of VAP.
FAU - Li, Yia-Ting
AU  - Li YT
AD  - Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 
      miki2700@gmail.com.
AD  - Division of Respiratory Therapy, Department of Internal Medicine, Chung Shan 
      Medical University Hospital, Taichung 402, Taiwan. miki2700@gmail.com.
FAU - Wang, Yao-Chen
AU  - Wang YC
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan 
      Medical University Hospital, Taichung 402, Taiwan. wang5717@ms21.hinet.net.
AD  - School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 
      wang5717@ms21.hinet.net.
FAU - Lee, Hsiang-Lin
AU  - Lee HL
AD  - Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 
      s31079@gmail.com.
AD  - Division of Gastroenterology, Department of Surgery, Chung Shan Medical 
      University Hospital, Taichung 402, Taiwan. s31079@gmail.com.
FAU - Tsao, Su-Chin
AU  - Tsao SC
AD  - Department of Nursing, Chung Shan Medical University Hospital, Taichung 402, 
      Taiwan. suchin311@gmail.com.
FAU - Lu, Min-Chi
AU  - Lu MC
AD  - Division of Infectious Diseases, Department of Internal Medicine, China Medical 
      University Hospital, Taichung 404, Taiwan. luminchi@gmail.com.
AD  - Department of Microbiology and Immunology, School of Medicine, China Medical 
      University, Taichung 402, Taiwan. luminchi@gmail.com.
FAU - Yang, Shun-Fa
AU  - Yang SF
AUID- ORCID: 0000-0002-0365-7927
AD  - Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 
      ysf@csmu.edu.tw.
AD  - Department of Medical Research, Chung Shan Medical University Hospital, Taichung 
      402, Taiwan. ysf@csmu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20190506
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Organ Failure/*blood/etiology
MH  - Pneumonia, Ventilator-Associated/*blood/complications/mortality
PMC - PMC6539645
OTO - NOTNLM
OT  - Monocyte chemoattractant protein-1
OT  - mortality
OT  - organ failure
OT  - ventilator-associated pneumonia
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/09 06:00
MHDA- 2019/08/21 06:00
PMCR- 2019/05/01
CRDT- 2019/05/09 06:00
PHST- 2019/04/08 00:00 [received]
PHST- 2019/04/30 00:00 [revised]
PHST- 2019/05/03 00:00 [accepted]
PHST- 2019/05/09 06:00 [entrez]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/08/21 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - ijms20092218 [pii]
AID - ijms-20-02218 [pii]
AID - 10.3390/ijms20092218 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 May 6;20(9):2218. doi: 10.3390/ijms20092218.