PMID- 31064103
OWN - NLM
STAT- MEDLINE
DCOM- 20191202
LR  - 20200225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 5
DP  - 2019 May 6
TI  - Fermented Cordyceps militaris Extract Prevents Hepatosteatosis and Adipocyte 
      Hypertrophy in High Fat Diet-Fed Mice.
LID - 10.3390/nu11051015 [doi]
LID - 1015
AB  - Nonalcoholic fatty liver diseases (NAFLD) is characterized by accumulation of 
      lipid droplets in the liver. The objective of this study was to evaluate 
      protective effects of fermented Cordyceps militaris extract by Pediococcus 
      pentosaceus ON188 (ONE) against hepatosteatosis and obesity in mice fed a 
      high-fat diet (HFD). Eight-week-old male C57BL/6J mice were fed HFD mixed with 
      ONE for four weeks and its effects on hepatosteatosis and obesity were examined. 
      Although ONE did not change food intake, it reduced body weights of mice at 
      administration dose of 200 mg/kg/day. Activities of lactate dehydrogenase (LDH), 
      aspartate transaminase (AST), and alanine transaminase (ALT) as plasma parameters 
      were reduced by ONE in a dose-dependent manner. Hepatic lipid droplets and 
      triglyceride (TG) levels were also reduced by ONE due to upregulation of fatty 
      acid oxidizing genes such as carnithine palmitoyltransferase (CPT1) and 
      peroxisomal proliferator activated receptor alpha(PPARalpha) mediated by induction of 
      sphingosine kinase 2 (SPHK2). In epididymal fat tissue, sizes of adipocytes were 
      significantly reduced by ONE in a dose-dependent manner. This is mainly due to 
      suppression of lipogenesis and upregulation of adipocyte browning genes. 
      Collectively, these results suggest that fermented ONE can activate fatty acid 
      oxidation via SPHK2 in the liver. It can also suppress lipogenesis and activate 
      browning in adipose tissue. Thus, ONE might have potential to be used for the 
      development of functional foods against liver dysfunction and obesity.
FAU - Tran, Nguyen Khoi Song
AU  - Tran NKS
AUID- ORCID: 0000-0002-4840-2004
AD  - Department of Life Science, Gachon University, Sungnam, Gyeonggido 13120, Korea. 
      marsnk217@gmail.com.
FAU - Kim, Goon-Tae
AU  - Kim GT
AD  - Department of Life Science, Gachon University, Sungnam, Gyeonggido 13120, Korea. 
      chng00@naver.com.
FAU - Park, Si-Hyun
AU  - Park SH
AD  - Department of Life Science, Gachon University, Sungnam, Gyeonggido 13120, Korea. 
      09050818@hanmail.net.
FAU - Lee, Dongyup
AU  - Lee D
AD  - Department of Life Science, Gachon University, Sungnam, Gyeonggido 13120, Korea. 
      nada_dongyup@naver.com.
FAU - Shim, Soon-Mi
AU  - Shim SM
AD  - Department of Food Science and Biotechnology, Sejong University, Seoul 05006, 
      Korea. soonmishim@sejong.ac.kr.
FAU - Park, Tae-Sik
AU  - Park TS
AUID- ORCID: 0000-0002-4629-947X
AD  - Department of Life Science, Gachon University, Sungnam, Gyeonggido 13120, Korea. 
      tspark@gachon.ac.kr.
LA  - eng
GR  - NRF‑2014M3A9B6069338/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20190506
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biological Products)
RN  - 0 (Deoxyadenosines)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
RN  - EC 2.7.1.- (sphingosine kinase 2, mouse)
RN  - GZ8VF4M2J8 (cordycepin)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/chemistry
MH  - Adipocytes/*drug effects
MH  - Adipose Tissue, White/cytology
MH  - Animals
MH  - Biological Products/chemistry/*pharmacology
MH  - Cordyceps/*chemistry
MH  - Deoxyadenosines/chemistry
MH  - Diet, High-Fat/*adverse effects
MH  - Fatty Liver/chemically induced/*prevention & control
MH  - Fermentation
MH  - Gene Expression Regulation/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oxidation-Reduction
MH  - Phosphotransferases (Alcohol Group Acceptor)/genetics/metabolism
MH  - Up-Regulation
PMC - PMC6566621
OTO - NOTNLM
OT  - fatty acid oxidation
OT  - fermentation
OT  - non-alcoholic steatohepatitis
OT  - obesity
OT  - sphingosine 1-phosphate
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/09 06:00
MHDA- 2019/12/04 06:00
PMCR- 2019/05/01
CRDT- 2019/05/09 06:00
PHST- 2019/04/08 00:00 [received]
PHST- 2019/04/26 00:00 [revised]
PHST- 2019/05/04 00:00 [accepted]
PHST- 2019/05/09 06:00 [entrez]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/12/04 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - nu11051015 [pii]
AID - nutrients-11-01015 [pii]
AID - 10.3390/nu11051015 [doi]
PST - epublish
SO  - Nutrients. 2019 May 6;11(5):1015. doi: 10.3390/nu11051015.