PMID- 31065268
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1687-8728 (Print)
IS  - 1687-8736 (Electronic)
IS  - 1687-8728 (Linking)
VI  - 2019
DP  - 2019
TI  - A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified 
      Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot 
      Experimental Study.
PG  - 3524207
LID - 10.1155/2019/3524207 [doi]
LID - 3524207
AB  - OBJECTIVE: To evaluate the effect of chemically modified tetracycline-3 (CMT-3) 
      and simvastatin on tooth relapse after orthodontic movement in rats using a novel 
      analysis method employing high-resolution micro-CT (Micro-CT) images. In 
      addition, the correlation between bone density and orthodontic relapse was also 
      evaluated for each experimental group. METHODS: Forty adult male Wistar rats had 
      stainless steel springs installed on their left upper first molars in order to 
      generate tooth movement for 18 days. After this initial period, the animals were 
      divided into three groups: (1) 30 mg/kg of CMT-3; (2) 5 mg/kg of simvastatin; and 
      (3) 0.5% carboxymethylcellulose, and each group was treated for 20 days. Micro-CT 
      images were analyzed (conventional method and 3D reconstruction) on the 7th and 
      18th days following spring fixation and finally, 20 days after treatment either 
      with CMT-3 or simvastatin (38th day). Bone mineral density (BMD) of the mesial 
      and distal roots of the upper first molar was also analyzed. RESULTS: The 
      difference was statistically significant between the groups as to recurrence 
      (p=0.048), and the post hoc test identified the value of p=0.007 between the 
      control group and the CMT-3 group. Simvastatin was not able to inhibit tooth 
      relapse. The bone mineral densities of both the mesial and distal roots were 
      different between the three groups, after the 20th day of drug use (p=0001 and p 
      < 0001). CONCLUSION: Our findings support the initial evidence that CMT-3 is able 
      to prevent relapse after tooth movement. Future trials in humans should evaluate 
      such treatment as a promising approach to preventing this common phenomenon. 
      CLINICAL RELEVANCE: Considering the results obtained, CMT-3 can be used to avoid 
      relapse after tooth movement.
FAU - Vieira, Giovanni Modesto
AU  - Vieira GM
AUID- ORCID: 0000-0002-6061-8123
AD  - Department of Medical Sciences, University of Brasilia (UnB), Campus Darcy 
      Ribeiro, Asa Norte, Zip Code: 70910-90, Brasilia, DF, Brazil.
FAU - Falcao, Denise Pinheiro
AU  - Falcao DP
AUID- ORCID: 0000-0002-5617-8401
AD  - Department of Medical Sciences, University of Brasilia (UnB), Campus Darcy 
      Ribeiro, Asa Norte, Zip Code: 70910-90, Brasilia, DF, Brazil.
FAU - de Queiroz, Sormani Bento Fernandes
AU  - de Queiroz SBF
AD  - Department of Surgery and Integrated Clinic, University of Aracatuba Dental 
      School (UNESP), 1193 Jose Bonifacio Street, Zip Code: 16015-050, Aracatuba, SP, 
      Brazil.
FAU - de Lima, Valthierre Nunes
AU  - de Lima VN
AUID- ORCID: 0000-0001-7673-4439
AD  - Department of Surgery and Integrated Clinic, University of Aracatuba Dental 
      School (UNESP), 1193 Jose Bonifacio Street, Zip Code: 16015-050, Aracatuba, SP, 
      Brazil.
FAU - Bentes de Azevedo, Ricardo
AU  - Bentes de Azevedo R
AD  - Department of Genetics and Morphology, Institute of Biological Sciences, 
      University of Brasilia (UnB), Campus Darcy Ribeiro, Asa Norte, Zip Code: 
      70910-90, Brasilia, DF, Brazil.
FAU - Tiziane, Valdenize
AU  - Tiziane V
AD  - Department of Medicine, Brasilia Children's Hospital Brasilia, St. de Habitacoes 
      Individuais Sul QI 15 - Lago Sul, Zip Code 71680-603, Brasilia, DF, Brazil.
FAU - Moreno, Heitor
AU  - Moreno H
AD  - Department of Farmacology, Campinas State University (FCM/UNICAMP), 126 Tessalia 
      Vieira de Camargo Street, Zip Code: 6111, Campinas, SP, Brazil.
FAU - Amorim, Rivadavio
AU  - Amorim R
AUID- ORCID: 0000-0001-6341-2027
AD  - Department of Medical Sciences, University of Brasilia (UnB), Campus Darcy 
      Ribeiro, Asa Norte, Zip Code: 70910-90, Brasilia, DF, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20190401
PL  - Egypt
TA  - Int J Dent
JT  - International journal of dentistry
JID - 101524183
PMC - PMC6466921
EDAT- 2019/05/09 06:00
MHDA- 2019/05/09 06:01
PMCR- 2019/04/01
CRDT- 2019/05/09 06:00
PHST- 2018/08/26 00:00 [received]
PHST- 2018/11/11 00:00 [revised]
PHST- 2018/12/03 00:00 [accepted]
PHST- 2019/05/09 06:00 [entrez]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/05/09 06:01 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 10.1155/2019/3524207 [doi]
PST - epublish
SO  - Int J Dent. 2019 Apr 1;2019:3524207. doi: 10.1155/2019/3524207. eCollection 2019.