PMID- 31065427
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 9
IP  - 12
DP  - 2018 Dec 1
TI  - Hyperspectral wide-field time domain single-pixel diffuse optical tomography 
      platform.
PG  - 6258-6272
LID - 10.1364/BOE.9.006258 [doi]
AB  - We present the design and comprehensive instrumental characterization of a time 
      domain diffuse optical tomography (TD-DOT) platform based on wide-field 
      illumination and wide-field hyperspectral time-resolved single-pixel detection 
      for functional and molecular imaging in turbid media. The proposed platform 
      combines two digital micro-mirror devices (DMDs) to generate structured light and 
      a spectrally resolved multi-anode photomultiplier tube (PMT) detector in time 
      domain for hyperspectral data acquisition over 16 wavelength channels based on 
      the time-correlated single-photon counting (TCSPC) technique. The design of the 
      proposed platform is described in detail and its characteristics in spatial, 
      temporal and spectral dimensions are calibrated and presented. The performance of 
      the system is further validated through a phantom study where two absorbers in 
      glass tubes with spectral contrast are mapped in a turbid medium of ~20 mm 
      thickness. The method presented here offers the potential of accelerating the 
      imaging process and improving reconstruction results in TD-DOT and thus 
      facilitates its wide spread use in preclinical and clinical in vivo imaging 
      scenarios.
FAU - Pian, Qi
AU  - Pian Q
AD  - Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 
      12180, USA.
AD  - Currently with Athinoula A. Martinos Center for Biomedical Imaging, Department of 
      Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
FAU - Yao, Ruoyang
AU  - Yao R
AD  - Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 
      12180, USA.
FAU - Intes, Xavier
AU  - Intes X
AD  - Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 
      12180, USA.
LA  - eng
GR  - R01 CA207725/CA/NCI NIH HHS/United States
GR  - R01 EB019443/EB/NIBIB NIH HHS/United States
PT  - Journal Article
DEP - 20181115
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC6491017
COIS- The authors declare that there are no conflicts of interest related to this 
      article.
EDAT- 2019/05/09 06:00
MHDA- 2019/05/09 06:01
PMCR- 2018/11/15
CRDT- 2019/05/09 06:00
PHST- 2018/06/27 00:00 [received]
PHST- 2018/08/27 00:00 [revised]
PHST- 2018/09/09 00:00 [accepted]
PHST- 2019/05/09 06:00 [entrez]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/05/09 06:01 [medline]
PHST- 2018/11/15 00:00 [pmc-release]
AID - 336287 [pii]
AID - 10.1364/BOE.9.006258 [doi]
PST - epublish
SO  - Biomed Opt Express. 2018 Nov 15;9(12):6258-6272. doi: 10.1364/BOE.9.006258. 
      eCollection 2018 Dec 1.