PMID- 31065447
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 9
IP  - 12
DP  - 2018 Dec 1
TI  - Buffer-averaging super-continuum source based spectral domain optical coherence 
      tomography for high speed imaging.
PG  - 6529-6544
LID - 10.1364/BOE.9.006529 [doi]
AB  - In super-continuum (SC) source based spectral domain optical coherence tomography 
      (SC-SDOCT), the stability of the power spectral density (PSD) has a significant 
      impact on OCT system sensitivity and image signal to noise ratio (SNR). High 
      speed imaging decreases the camera's exposure time, thus each A-scan contained 
      fewer laser pulse excited SC wideband emissions, resulting in a decrease of SNR. 
      In this manuscript, we present a buffer-averaging SC-SDOCT (BASC-SDOCT) to 
      improve the system's performance without losing imaging speed, taking advantage 
      of the excess output power from typical SC sources. In our proposed technique, 
      the output light from SC was passed through a fiber based light buffering and 
      averaging system to improve the PSD stability by averaging 8 SC emissions. The 
      results showed that 6.96 micros of SC emission after buffering and averaging can 
      achieve the same PSD stability equivalent to a longer exposure time of 55.68 micros, 
      despite increasing the imaging speed from 16.8 kHz to 91.9 kHz. The system 
      sensitivity was improved by 8.6 dB, reaching 100.6 dB, which in turn improved SNR 
      of structural imaging, Doppler OCT velocity measurement, and speckle variance OCT 
      (SVOCT) angiographic imaging as demonstrated by phantom and in vivo experiments.
FAU - Chen, Chaoliang
AU  - Chen C
AD  - Biophotonics and Bioengineering Lab, Department of Electrical, Computer, and 
      Biomedical Engineering, Ryerson University, Toronto, Ontario, Canada.
FAU - Shi, Weisong
AU  - Shi W
AD  - Biophotonics and Bioengineering Lab, Department of Electrical, Computer, and 
      Biomedical Engineering, Ryerson University, Toronto, Ontario, Canada.
AD  - Department of Optical Engineering, Nanjing University of Science and Technology, 
      Nanjing, Jiangsu, China.
FAU - Reyes, Robnier
AU  - Reyes R
AD  - Biophotonics and Bioengineering Lab, Department of Electrical, Computer, and 
      Biomedical Engineering, Ryerson University, Toronto, Ontario, Canada.
FAU - Yang, Victor X D
AU  - Yang VXD
AD  - Biophotonics and Bioengineering Lab, Department of Electrical, Computer, and 
      Biomedical Engineering, Ryerson University, Toronto, Ontario, Canada.
AD  - Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, 
      Canada.
AD  - Division of Neurosurgery, Faculty of Medicine, University of Toronto, Toronto, 
      Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20181128
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC6491018
COIS- The authors declare that there are no conflicts of interest related to this 
      article.
EDAT- 2019/05/09 06:00
MHDA- 2019/05/09 06:01
PMCR- 2018/11/28
CRDT- 2019/05/09 06:00
PHST- 2018/11/08 00:00 [received]
PHST- 2018/11/15 00:00 [accepted]
PHST- 2019/05/09 06:00 [entrez]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/05/09 06:01 [medline]
PHST- 2018/11/28 00:00 [pmc-release]
AID - 351377 [pii]
AID - 10.1364/BOE.9.006529 [doi]
PST - epublish
SO  - Biomed Opt Express. 2018 Nov 28;9(12):6529-6544. doi: 10.1364/BOE.9.006529. 
      eCollection 2018 Dec 1.