PMID- 31065475
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231011
IS  - 2189-7948 (Electronic)
IS  - 2189-6577 (Print)
IS  - 2189-7948 (Linking)
VI  - 20
IP  - 3
DP  - 2019 May
TI  - Clinical remission of an inoperable malignant insulinoma by the combination 
      treatment with octreotide and everolimus.
PG  - 107-110
LID - 10.1002/jgf2.235 [doi]
AB  - We report a 52-year-old woman with inoperable malignant insulinoma with multiple 
      liver metastases. Histological examination of biopsy specimens from the 
      pancreatic and hepatic lesions revealed pancreatic neuroendocrine tumor (pNET), 
      G2. The tumor cells were positive for somatostatin receptor (SSTR) 2, 5, and the 
      mammalian target of rapamycin (mTOR). Monthly intramuscular administration of 
      octreotide LAR and once-daily oral administration of everolimus combination 
      treatment markedly reduced the sizes of liver metastases, and hypoglycemia was 
      well controlled. Combination treatment with somatostatin analog and mTOR 
      inhibitor may be another effective approach in inoperable metastatic malignant 
      insulinoma.
FAU - Akahori, Hiroshi
AU  - Akahori H
AD  - Department of Internal Medicine (Endocrinology and Metabolism) Toyama Prefectural 
      Central Hospital Toyama-city Toyama Japan.
LA  - eng
PT  - Case Reports
DEP - 20190111
PL  - Japan
TA  - J Gen Fam Med
JT  - Journal of general and family medicine
JID - 101689875
PMC - PMC6498131
OTO - NOTNLM
OT  - everolimus
OT  - malignant insulinoma
OT  - mammalian target of rapamycin
OT  - multiple liver metastases
OT  - octreotide
OT  - somatostatin receptor
COIS- The author has stated explicitly that there are no conflicts of interest in 
      connection with this article.
EDAT- 2019/05/09 06:00
MHDA- 2019/05/09 06:01
PMCR- 2019/01/11
CRDT- 2019/05/09 06:00
PHST- 2018/04/17 00:00 [received]
PHST- 2018/11/20 00:00 [revised]
PHST- 2018/12/16 00:00 [accepted]
PHST- 2019/05/09 06:00 [entrez]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/05/09 06:01 [medline]
PHST- 2019/01/11 00:00 [pmc-release]
AID - JGF2235 [pii]
AID - 10.1002/jgf2.235 [doi]
PST - epublish
SO  - J Gen Fam Med. 2019 Jan 11;20(3):107-110. doi: 10.1002/jgf2.235. eCollection 2019 
      May.