PMID- 31066122
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20231213
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
VI  - 31
IP  - 9
DP  - 2019 Sep
TI  - Glyphosate and glyphosate-based herbicide exposure during the peripartum period 
      affects maternal brain plasticity, maternal behaviour and microbiome.
PG  - e12731
LID - 10.1111/jne.12731 [doi]
AB  - Glyphosate is found in a large array of non-selective herbicides such as Roundup(R) 
      (Monsanto, Creve Coeur, MO, USA) and is by far the most widely used herbicide. 
      Recent work in rodent models suggests that glyphosate-based herbicides during 
      development can affect neuronal communication and result in altered behaviours, 
      albeit through undefined mechanisms of action. To our knowledge, no study has 
      investigated the effects glyphosate or its formulation in herbicide on maternal 
      behaviour and physiology. In the present study, relatively low doses of 
      glyphosate (5 mg kg(-1)  d(-1) ), Roundup(R) (5 mg kg(-1)  d(-1) glyphosate 
      equivalent), or vehicle were administered by ingestion to Sprague-Dawley rats 
      from gestational day (GD) 10 to postpartum day (PD)22. The treatments 
      significantly altered licking behaviour toward pups between PD2 and PD6. We also 
      show in the dams at PD22 that Roundup exposure affected the maturation of 
      doublecortin-immunoreactive new neurones in the dorsal dentate gyrus of the 
      hippocampus of the mother. In addition, the expression of synaptophysin was 
      up-regulated by glyphosate in the dorsal and ventral dentate gyrus and CA3 
      regions of the hippocampus, and down-regulated in the cingulate gyrus. Although a 
      direct effect of glyphosate alone or its formulation on the central nervous 
      system is currently not clear, we show that gut microbiota is significantly 
      altered by the exposure to the pesticides, with significant alteration of the 
      phyla Bacteroidetes and Firmicutes. This is the first study to provide evidence 
      that glyphosate alone or in formulation (Roundup) differentially affects maternal 
      behaviour and modulates neuroplasticity and gut microbiota in the mother.
CI  - (c) 2019 British Society for Neuroendocrinology.
FAU - Dechartres, Julie
AU  - Dechartres J
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sante Environnement 
      et Travail), UMR_S 1085, Rennes, France.
FAU - Pawluski, Jodi L
AU  - Pawluski JL
AUID- ORCID: 0000-0002-8240-8178
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sante Environnement 
      et Travail), UMR_S 1085, Rennes, France.
FAU - Gueguen, Marie-Madeleine
AU  - Gueguen MM
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sante Environnement 
      et Travail), UMR_S 1085, Rennes, France.
FAU - Jablaoui, Amin
AU  - Jablaoui A
AD  - Micalis, INRA, AgroParisTech, Univ Paris-Saclay, Jouy-en-Josas, France.
FAU - Maguin, Emmanuelle
AU  - Maguin E
AD  - Micalis, INRA, AgroParisTech, Univ Paris-Saclay, Jouy-en-Josas, France.
FAU - Rhimi, Moez
AU  - Rhimi M
AD  - Micalis, INRA, AgroParisTech, Univ Paris-Saclay, Jouy-en-Josas, France.
FAU - Charlier, Thierry D
AU  - Charlier TD
AUID- ORCID: 0000-0003-2759-6572
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sante Environnement 
      et Travail), UMR_S 1085, Rennes, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190526
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Herbicides)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/drug effects
MH  - Doublecortin Protein
MH  - Female
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Glycine/*analogs & derivatives/toxicity
MH  - Herbicides/*toxicity
MH  - Hippocampus/*drug effects/physiology
MH  - Maternal Behavior/*drug effects/physiology
MH  - Neurogenesis/drug effects
MH  - Neuronal Plasticity/*drug effects
MH  - Neurons/drug effects/physiology
MH  - Peripartum Period/*drug effects
MH  - Rats, Sprague-Dawley
MH  - Glyphosate
OTO - NOTNLM
OT  - cingulate gyrus
OT  - gut microbiota
OT  - hippocampus
OT  - neurogenesis
OT  - neuroplasticity
EDAT- 2019/05/09 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/05/09 06:00
PHST- 2019/01/09 00:00 [received]
PHST- 2019/05/03 00:00 [revised]
PHST- 2019/05/03 00:00 [accepted]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/05/09 06:00 [entrez]
AID - 10.1111/jne.12731 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2019 Sep;31(9):e12731. doi: 10.1111/jne.12731. Epub 2019 May 
      26.