PMID- 31066193
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20231013
IS  - 1526-968X (Electronic)
IS  - 1526-954X (Print)
IS  - 1526-954X (Linking)
VI  - 57
IP  - 7-8
DP  - 2019 Jul
TI  - Recent insights on the role and regulation of retinoic acid signaling during 
      epicardial development.
PG  - e23303
LID - 10.1002/dvg.23303 [doi]
AB  - The vitamin A metabolite, retinoic acid, carries out essential and conserved 
      roles in vertebrate heart development. Retinoic acid signals via retinoic acid 
      receptors (RAR)/retinoid X receptors (RXRs) heterodimers to induce the expression 
      of genes that control cell fate specification, proliferation, and 
      differentiation. Alterations in retinoic acid levels are often associated with 
      congenital heart defects. Therefore, embryonic levels of retinoic acid need to be 
      carefully regulated through the activity of enzymes, binding proteins and 
      transporters involved in vitamin A metabolism. Here, we review evidence of the 
      complex mechanisms that control the fetal uptake and synthesis of retinoic acid 
      from vitamin A precursors. Next, we highlight recent evidence of the role of 
      retinoic acid in orchestrating myocardial compact zone growth and coronary 
      vascular development.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Wang, Suya
AU  - Wang S
AD  - Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
FAU - Moise, Alexander R
AU  - Moise AR
AUID- ORCID: 0000-0003-2307-6035
AD  - Medical Sciences Division, Northern Ontario School of Medicine, Sudbury, Ontario, 
      Canada.
AD  - Departments of Chemistry and Biochemistry, and Biology and Biomolecular Sciences 
      Program, Laurentian University, Sudbury, Ontario, Canada.
AD  - Department of Pharmacology and Toxicology, School of Pharmacy, University of 
      Kansas, Lawrence, Kansas.
LA  - eng
GR  - R01 HD077260/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190508
PL  - United States
TA  - Genesis
JT  - Genesis (New York, N.Y. : 2000)
JID - 100931242
RN  - 0 (Receptors, Retinoic Acid)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Pericardium/*embryology/metabolism
MH  - Receptors, Retinoic Acid/genetics/metabolism
MH  - *Signal Transduction
MH  - Tretinoin/*metabolism
PMC - PMC6682438
MID - NIHMS1028793
OTO - NOTNLM
OT  - congenital heart defects
OT  - epicardium
OT  - heart development
OT  - retinoic acid
OT  - vitamin A
EDAT- 2019/05/09 06:00
MHDA- 2019/12/31 06:00
PMCR- 2020/07/01
CRDT- 2019/05/09 06:00
PHST- 2019/03/11 00:00 [received]
PHST- 2019/04/23 00:00 [revised]
PHST- 2019/04/24 00:00 [accepted]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2019/05/09 06:00 [entrez]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 10.1002/dvg.23303 [doi]
PST - ppublish
SO  - Genesis. 2019 Jul;57(7-8):e23303. doi: 10.1002/dvg.23303. Epub 2019 May 8.