PMID- 31066997
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20191217
IS  - 1751-553X (Electronic)
IS  - 1751-5521 (Linking)
VI  - 41
IP  - 4
DP  - 2019 Aug
TI  - Monosomal karyotypes apart from complex karyotypes independently predict the 
      outcome of myelodysplastic syndrome patients using a fluorescence in situ 
      hybridization panel and conventional cytogenetics.
PG  - 519-529
LID - 10.1111/ijlh.13041 [doi]
AB  - INTRODUCTION: The aim of the study was to analyze monosomal karyotype (MK) 
      occurrence and the relationship between MKs and complex karyotypes (CKs) and to 
      determine the prognostic significance of MKs in MDS patients based on 
      conventional cytogenetic (CC) and fluorescence in situ hybridization (FISH) 
      analyses. METHODS: CC and FISH analyses were conducted for 216 primary MDS 
      patients. Follow-ups and statistical analysis were conducted. RESULTS: A total of 
      25 (11.6%) patients with MKs were identified by FISH and CC analyses, and 23 
      (92%) of these MKs were also CKs. Only 19 patients (8.8%) with MKs were 
      identified by CC analysis. Patients with MKs had higher bone marrow (BM) blast 
      counts (P = 0.006), incidence of very high risk according to International 
      Prognostic Scoring System-Revised (IPSS-R) (P < 0.001), leukemic transformation 
      (P = 0.003,) and death rates (P < 0.001) than those without MKs. Overall survival 
      (OS) and progression-free survival (PFS) of MK or CK patients which were 
      additionally detected by FISH and CC analyses had no statistical significance 
      with those MK or CK patients detected by CC analyses separately. Multivariate 
      analysis indicated that MK (P < 0.001), blast in BM (P < 0.001) and age 
      (P = 0.028) were inferior independent prognostic factors in OS, whereas CK 
      (P = 0.003) was the inferior independent prognostic factor in PFS. CONCLUSION: 
      The MDS FISH panel may provide additional information for defining MKs beyond CC 
      analysis. MK was an important indicator of OS in MDS patients, and CK indicated 
      inferior disease progression but did not influence OS according to CC and FISH 
      analyses.
CI  - (c) 2019 John Wiley & Sons Ltd.
FAU - Wang, Na
AU  - Wang N
AUID- ORCID: 0000-0001-9552-0524
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
AD  - School of Medicine, Shandong University, Jinan, China.
FAU - Xu, Hongzhi
AU  - Xu H
AUID- ORCID: 0000-0002-7772-1506
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Li, Qing
AU  - Li Q
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Sui, Xiaohui
AU  - Sui X
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Jiang, Yujie
AU  - Jiang Y
AUID- ORCID: 0000-0003-2199-238X
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Fang, Xiaosheng
AU  - Fang X
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Zhen, Changqing
AU  - Zhen C
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Ding, Mei
AU  - Ding M
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Yuan, Dai
AU  - Yuan D
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Zhang, Lingyan
AU  - Zhang L
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, China.
AD  - School of Medicine, Shandong University, Jinan, China.
LA  - eng
GR  - Program of Shandong Medical Leading Talent/
GR  - 2017WS200/the Medicine and Health Science Technology Development Project of 
      Shandong Province/
GR  - 2017GSF18189/Technology Development Projects of Shandong Province/
GR  - Taishan Scholar Foundation of Shandong Province/
GR  - 2018CXGC1213/Key Research and Development Program of Shandong Province/
GR  - 81270598/National Natural Science Foundation of China/
GR  - 81473486/National Natural Science Foundation of China/
GR  - 81770210/National Natural Science Foundation of China/
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190508
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - *Karyotyping
MH  - Male
MH  - Middle Aged
MH  - *Monosomy
MH  - *Myelodysplastic Syndromes/genetics/mortality/pathology
OTO - NOTNLM
OT  - cytogenetics
OT  - fluorescence in situ hybridization
OT  - monosomal karyotype
OT  - myelodysplastic syndromes
OT  - prognosis
EDAT- 2019/05/09 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/05/09 06:00
PHST- 2019/01/31 00:00 [received]
PHST- 2019/04/06 00:00 [revised]
PHST- 2019/04/09 00:00 [accepted]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/05/09 06:00 [entrez]
AID - 10.1111/ijlh.13041 [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2019 Aug;41(4):519-529. doi: 10.1111/ijlh.13041. Epub 2019 May 
      8.