PMID- 31067319
OWN - NLM
STAT- MEDLINE
DCOM- 20191010
LR  - 20191010
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 60
IP  - 6
DP  - 2019 May 1
TI  - Vitreomacular Interface Abnormalities and Glaucoma in an Elderly Population (The 
      MONTRACHET Study).
PG  - 1996-2002
LID - 10.1167/iovs.18-26510 [doi]
AB  - PURPOSE: To investigate the prevalence of vitreomacular interface abnormalities 
      (VMIAs) in a French elderly glaucomatous population. METHODS: Using a 
      population-based study, the MONTRACHET (Maculopathy Optic Nerve nuTRition 
      neurovAsCular and HEarT diseases) study conducted in Dijon from 2009 to 2013 in 
      individuals older than 75 years, the prevalence of VMIAs was estimated on 
      glaucoma patients. RESULTS: A total of 1130 participants (2225 eyes) were 
      included in the study. The mean age of participants was 82.3 +/- 3.8 years, and 
      62.74% were women. Regarding the frequency of all VMIAs, there was no statistical 
      difference between glaucoma patients and nonglaucoma participants (51.85% vs. 
      53.92%, respectively, P = 0.372). In univariate analysis, vitreomacular 
      adherences were more frequent in nonglaucoma participants (18.39% vs. 10.78%, P = 
      0.036). Epiretinal membranes were more frequent in the glaucomatous population 
      (47.06% vs. 38.13%, P = 0.018). The prevalence of macular cysts was comparable in 
      the two groups (7.84% vs. 5.64%, P = 0.262). Macular cysts were more frequent in 
      eyes treated with preservative-free, IOP-lowering eye drops when compared with 
      the eyes of nonglaucomatous participants treated with IOP-lowering eye drops 
      containing a preservative (26.67% vs. 3.37% and 5.76%, respectively, P < 0.001). 
      In multivariate analysis, these results were no longer significant. CONCLUSIONS: 
      The prevalence of VMIAs was high in this elderly population and similar in both 
      glaucomatous and nonglaucomatous participants. The information provided by 
      macular optical coherence tomography scans should be considered with caution when 
      used for glaucoma management in elderly patients.
FAU - Blanc, Julie
AU  - Blanc J
AD  - University Hospital, Department of Ophthalmology, Dijon, France.
FAU - Seydou, Alassane
AU  - Seydou A
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM), Clinical 
      Center Investigation, Clinical Epidemiology/Clinical Trials Unit, Universal 
      Hospital, Dijon, France.
AD  - Centre des Sciences du Gout et de l'Alimentation, Centre National pour la 
      Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique 
      (INRA), University Bourgogne Franche-Comte, Dijon, France.
FAU - Ben Ghezala, Ines
AU  - Ben Ghezala I
AD  - University Hospital, Department of Ophthalmology, Dijon, France.
FAU - Deschasse, Clemence
AU  - Deschasse C
AD  - University Hospital, Department of Ophthalmology, Dijon, France.
FAU - Meillon, Cyril
AU  - Meillon C
AD  - University Hospital, Department of Ophthalmology, Dijon, France.
FAU - Bron, Alain M
AU  - Bron AM
AD  - University Hospital, Department of Ophthalmology, Dijon, France.
AD  - Centre des Sciences du Gout et de l'Alimentation, Centre National pour la 
      Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique 
      (INRA), University Bourgogne Franche-Comte, Dijon, France.
FAU - Binquet, Christine
AU  - Binquet C
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM), Clinical 
      Center Investigation, Clinical Epidemiology/Clinical Trials Unit, Universal 
      Hospital, Dijon, France.
AD  - Centre des Sciences du Gout et de l'Alimentation, Centre National pour la 
      Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique 
      (INRA), University Bourgogne Franche-Comte, Dijon, France.
FAU - Creuzot-Garcher, Catherine
AU  - Creuzot-Garcher C
AD  - University Hospital, Department of Ophthalmology, Dijon, France.
AD  - Centre des Sciences du Gout et de l'Alimentation, Centre National pour la 
      Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique 
      (INRA), University Bourgogne Franche-Comte, Dijon, France.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Comorbidity
MH  - Female
MH  - Follow-Up Studies
MH  - France/epidemiology
MH  - Glaucoma/*diagnosis/epidemiology/physiopathology
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Male
MH  - Nerve Fibers/pathology
MH  - Prospective Studies
MH  - Retinal Diseases/*diagnosis/epidemiology/physiopathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
EDAT- 2019/05/09 06:00
MHDA- 2019/10/11 06:00
CRDT- 2019/05/09 06:00
PHST- 2019/05/09 06:00 [entrez]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
AID - 2733391 [pii]
AID - 10.1167/iovs.18-26510 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2019 May 1;60(6):1996-2002. doi: 
      10.1167/iovs.18-26510.