PMID- 31067538
OWN - NLM
STAT- MEDLINE
DCOM- 20210301
LR  - 20210301
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 101
IP  - 3
DP  - 2020
TI  - Effects of Proton Pump Inhibitor on the Distribution of Helicobacter pylori and 
      Associated Gastritis in Patients with Gastric Atrophy.
PG  - 279-286
LID - 10.1159/000499424 [doi]
AB  - BACKGROUND/AIMS: Acid suppression therapy is thought to be associated with the 
      topography of Helicobacter pylori and associated gastritis, leading to 
      corpus-predominant gastritis. This study was aimed to investigate the influence 
      of proton pump inhibitor (PPI) treatment on the distribution of H. pylori and 
      associated gastritis in patients with atrophic change. METHODS: Patients who 
      underwent endoscopic resection for gastric neoplasms and received PPI for 2 
      months were prospectively analyzed. Biopsy specimens were obtained from 5 areas 
      in the stomach before, during, and after the treatment with PPI. Histological 
      examination was -performed using the updated Sydney system, and 
      -bacterial density of H. pylori was further graded by immunohistochemistry 
      (ClinicalTrials.gov registration number NCT02449941). RESULTS: A total of 15 
      patients were analyzed, of whom 7 had H. pylori infection. The degree of activity 
      and inflammation were greater in patients with H. pylori infection than in those 
      without H. pylori infection. During the PPI treatment, the density of H. pylori 
      decreased not only in the antrum but also in the corpus. The degree of activity 
      and inflammation improved significantly in the antrum, particularly in the 
      presence of H. pylori infection, while the corpus gastritis was not affected by 
      PPI use. Atrophy and intestinal metaplasia remained unchanged in both regions of 
      the stomach. The observed changes reverted following the discontinuation of PPI 
      treatment. CONCLUSION: PPI treatment decreased H. pylori both in the antrum and 
      the corpus in patients with atrophic gastritis. Antral gastritis improved during 
      PPI treatment, whereas no changes were found in the corpus.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Gong, Eun Jeong
AU  - Gong EJ
AD  - Department of Internal Medicine, University of Ulsan College of Medicine, 
      Gangneung Asan Hospital, Gangneung, Republic of Korea.
FAU - Kim, Do Hoon
AU  - Kim DH
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Ahn, Ji Yong
AU  - Ahn JY
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea, ji110@hanmail.net.
FAU - Na, Hee Kyong
AU  - Na HK
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Jung, Kee Wook
AU  - Jung KW
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Lee, Jeong Hoon
AU  - Lee JH
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Choi, Kee Don
AU  - Choi KD
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Song, Ho June
AU  - Song HJ
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Lee, Gin Hyug
AU  - Lee GH
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Jung, Hwoon-Yong
AU  - Jung HY
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Republic of Korea.
FAU - Park, Yangsoon
AU  - Park Y
AD  - Department of Pathology, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Republic of Korea.
FAU - Kim, Min-Ju
AU  - Kim MJ
AD  - Department of Clinical Epidemiology and Biostatistics, University of Ulsan 
      College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
LA  - eng
SI  - ClinicalTrials.gov/NCT02449941
PT  - Journal Article
PT  - Observational Study
DEP - 20190508
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Endoscopic Mucosal Resection
MH  - Female
MH  - Gastric Mucosa/drug effects/microbiology/pathology/surgery
MH  - Gastritis, Atrophic/*drug therapy/microbiology/pathology
MH  - Helicobacter Infections/*drug therapy/microbiology/pathology
MH  - Helicobacter pylori/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Pyloric Antrum/drug effects/microbiology/pathology/surgery
MH  - Stomach Neoplasms/microbiology/pathology/*surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Gastritis
OT  - Helicobacter pylori
OT  - Proton pump inhibitors
EDAT- 2019/05/09 06:00
MHDA- 2021/03/02 06:00
CRDT- 2019/05/09 06:00
PHST- 2018/12/27 00:00 [received]
PHST- 2019/03/05 00:00 [accepted]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2021/03/02 06:00 [medline]
PHST- 2019/05/09 06:00 [entrez]
AID - 000499424 [pii]
AID - 10.1159/000499424 [doi]
PST - ppublish
SO  - Digestion. 2020;101(3):279-286. doi: 10.1159/000499424. Epub 2019 May 8.