PMID- 31067553
OWN - NLM
STAT- MEDLINE
DCOM- 20200430
LR  - 20200430
IS  - 1423-0275 (Electronic)
IS  - 0301-1569 (Linking)
VI  - 81
IP  - 2-3
DP  - 2019
TI  - Significance of Cytokeratin-1 Single-Nucleotide Polymorphism and Protein Level in 
      Susceptibility to Vocal Leukoplakia and Laryngeal Squamous Cell Carcinoma.
PG  - 121-129
LID - 10.1159/000497747 [doi]
AB  - OBJECTIVE: To investigate the association between the cytokeratin (CK)-1 
      single-nucleotide polymorphism (SNP), the protein level of CK-1 and the risk of 
      vocal leukoplakia and laryngeal squamous cell carcinoma (LSCC). METHODS: In this 
      case-control study, 155 patients with vocal leukoplakia, 323 patients with LSCC, 
      and 266 healthy controls were genotyped for the CK-1 (SNP RS14024) gene using 
      pyrosequencing. The protein expression level of CK-1 was analyzed in vocal 
      leukoplakia, LSCC, and vocal polyp patients by immunohistochemistry (IHC). 
      RESULTS: Of the CK-1 RS14024 polymorphism, the heterozygote AG and homozygote GG 
      genotype exhibited a significantly increased risk of LSCC (AG: OR = 2.16, p = 
      0.014; GG: OR = 2.15, p = 0.018) compared to normal controls. A higher protein 
      expression level of CK-1 was detected in patients with LSCC compared to vocal 
      leukoplakia and polyps (both p < 0.001), and a significant increasing trend of 
      CK-1 protein expression level from mild-moderate dysplasia to moderate-severe 
      dysplasia in vocal leukoplakia patients was also observed (p = 0.006). 
      CONCLUSIONS: This study demonstrates that the CK-1 SNP and high protein 
      expression levels are associated with vocal leukoplakia and LSCC and promote the 
      transformation from vocal leukoplakia to LSCC in a Chinese Han population.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Yang, Yue
AU  - Yang Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat 
      Hospital, Fudan University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and 
      Throat Hospital, Fudan University, Shanghai, China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat 
      Hospital, Fudan University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and 
      Throat Hospital, Fudan University, Shanghai, China.
FAU - Wu, Haitao
AU  - Wu H
AD  - Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat 
      Hospital, Fudan University, Shanghai, China, eentwuhaitao@163.com.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and 
      Throat Hospital, Fudan University, Shanghai, China, eentwuhaitao@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190508
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Keratin-1)
SB  - IM
MH  - Carcinoma, Squamous Cell/diagnosis/*genetics/metabolism
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Immunohistochemistry
MH  - Keratin-1/*genetics/metabolism
MH  - Laryngeal Neoplasms/diagnosis/*genetics/metabolism
MH  - Leukoplakia/diagnosis/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Retrospective Studies
MH  - Vocal Cords/*pathology
OTO - NOTNLM
OT  - Cytokeratin-1
OT  - Laryngeal squamous cell carcinoma
OT  - Protein level
OT  - Single-nucleotide polymorphism
OT  - Vocal leukoplakia
EDAT- 2019/05/09 06:00
MHDA- 2020/05/01 06:00
CRDT- 2019/05/09 06:00
PHST- 2018/11/19 00:00 [received]
PHST- 2019/01/30 00:00 [accepted]
PHST- 2019/05/09 06:00 [pubmed]
PHST- 2020/05/01 06:00 [medline]
PHST- 2019/05/09 06:00 [entrez]
AID - 000497747 [pii]
AID - 10.1159/000497747 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 2019;81(2-3):121-129. doi: 10.1159/000497747. 
      Epub 2019 May 8.