PMID- 31067778
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 9
DP  - 2019 May 7
TI  - Mechanisms of the Metabolic Shift during Somatic Cell Reprogramming.
LID - 10.3390/ijms20092254 [doi]
LID - 2254
AB  - Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced 
      pluripotent stem cells (iPSCs), hold a huge promise for regenerative medicine, 
      drug development, and disease modeling. PSCs have unique metabolic features that 
      are akin to those of cancer cells, in which glycolysis predominates to produce 
      energy as well as building blocks for cellular components. Recent studies 
      indicate that the unique metabolism in PSCs is not a mere consequence of their 
      preference for a low oxygen environment, but is an active process for maintaining 
      self-renewal and pluripotency, possibly in preparation for rapid response to the 
      metabolic demands of differentiation. Understanding the regulatory mechanisms of 
      this unique metabolism in PSCs is essential for proper derivation, generation, 
      and maintenance of PSCs. In this review, we discuss the metabolic features of 
      PSCs and describe the current understanding of the mechanisms of the metabolic 
      shift during reprogramming from somatic cells to iPSCs, in which the metabolism 
      switches from oxidative phosphorylation (OxPhos) to glycolysis.
FAU - Nishimura, Ken
AU  - Nishimura K
AD  - Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba 305-8577, Japan. ken-nishimura@md.tsukuba.ac.jp.
FAU - Fukuda, Aya
AU  - Fukuda A
AD  - Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba 305-8577, Japan. fukudaa@md.tsukuba.ac.jp.
FAU - Hisatake, Koji
AU  - Hisatake K
AUID- ORCID: 0000-0002-5795-3115
AD  - Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba 305-8577, Japan. kojihisa@md.tsukuba.ac.jp.
LA  - eng
GR  - JP25460354/Japan Society for the Promotion of Science/
GR  - JP26870074/Japan Society for the Promotion of Science/
GR  - JP16K08610/Japan Society for the Promotion of Science/
PT  - Journal Article
PT  - Review
DEP - 20190507
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - *Cellular Reprogramming
MH  - *Energy Metabolism
MH  - Humans
MH  - Mitochondria/metabolism
MH  - Pluripotent Stem Cells/cytology/*metabolism
PMC - PMC6539623
OTO - NOTNLM
OT  - ESC
OT  - OxPhos: glycolysis
OT  - PSC
OT  - hypoxia
OT  - iPSC
OT  - metabolism
OT  - mitochondrion
OT  - somatic cell reprogramming
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/10 06:00
MHDA- 2019/09/04 06:00
PMCR- 2019/05/01
CRDT- 2019/05/10 06:00
PHST- 2019/04/01 00:00 [received]
PHST- 2019/04/25 00:00 [revised]
PHST- 2019/05/06 00:00 [accepted]
PHST- 2019/05/10 06:00 [entrez]
PHST- 2019/05/10 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - ijms20092254 [pii]
AID - ijms-20-02254 [pii]
AID - 10.3390/ijms20092254 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 May 7;20(9):2254. doi: 10.3390/ijms20092254.