PMID- 31068585
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20210109
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 10
IP  - 1
DP  - 2019 May 8
TI  - Enveloped viruses distinct from HBV induce dissemination of hepatitis D virus in 
      vivo.
PG  - 2098
LID - 10.1038/s41467-019-10117-z [doi]
LID - 2098
AB  - Hepatitis D virus (HDV) doesn't encode envelope proteins for packaging of its 
      ribonucleoprotein (RNP) and typically relies on the surface glycoproteins (GPs) 
      from hepatitis B virus (HBV) for virion assembly, envelopment and cellular 
      transmission. HDV RNA genome can efficiently replicate in different tissues and 
      species, raising the possibility that it evolved, and/or is still able to 
      transmit, independently of HBV. Here we show that alternative, HBV-unrelated 
      viruses can act as helper viruses for HDV. In vitro, envelope GPs from several 
      virus genera, including vesiculovirus, flavivirus and hepacivirus, can package 
      HDV RNPs, allowing efficient egress of HDV particles in the extracellular milieu 
      of co-infected cells and subsequent entry into cells expressing the relevant 
      receptors. Furthermore, HCV can propagate HDV infection in the liver of 
      co-infected humanized mice for several months. Further work is necessary to 
      evaluate whether HDV is currently transmitted by HBV-unrelated viruses in humans.
FAU - Perez-Vargas, Jimena
AU  - Perez-Vargas J
AUID- ORCID: 0000-0002-4337-7903
AD  - CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Universite 
      Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allee d'Italie, 
      F-69007, Lyon, France.
FAU - Amirache, Fouzia
AU  - Amirache F
AD  - CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Universite 
      Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allee d'Italie, 
      F-69007, Lyon, France.
FAU - Boson, Bertrand
AU  - Boson B
AD  - CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Universite 
      Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allee d'Italie, 
      F-69007, Lyon, France.
FAU - Mialon, Chloe
AU  - Mialon C
AD  - CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Universite 
      Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allee d'Italie, 
      F-69007, Lyon, France.
FAU - Freitas, Natalia
AU  - Freitas N
AD  - CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Universite 
      Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allee d'Italie, 
      F-69007, Lyon, France.
FAU - Sureau, Camille
AU  - Sureau C
AD  - Molecular Virology laboratory, Institut National de la Transfusion Sanguine 
      (INTS), CNRS Inserm U1134, 6 rue Alexandre Cabanel, F-75739, Paris, France.
FAU - Fusil, Floriane
AU  - Fusil F
AD  - CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Universite 
      Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allee d'Italie, 
      F-69007, Lyon, France.
FAU - Cosset, Francois-Loic
AU  - Cosset FL
AUID- ORCID: 0000-0001-8842-3726
AD  - CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Universite 
      Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allee d'Italie, 
      F-69007, Lyon, France. flcosset@ens-lyon.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190508
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (RNA, Viral)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
CIN - Hepatology. 2020 Jan;71(1):380-382. PMID: 31465549
CIN - Gastroenterology. 2019 Nov;157(5):1431-1432. PMID: 31586567
MH  - Animals
MH  - Cell Line, Tumor
MH  - Coinfection/*transmission/virology
MH  - Flavivirus/metabolism
MH  - Hepacivirus/metabolism/pathogenicity
MH  - Hepatitis D/*transmission/virology
MH  - Hepatitis Delta Virus/isolation & purification/pathogenicity/*physiology
MH  - Hepatocytes/transplantation/virology
MH  - Humans
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, Transgenic
MH  - Primary Cell Culture
MH  - RNA, Viral/isolation & purification
MH  - Ribonucleoproteins/metabolism
MH  - Vesiculovirus/metabolism
MH  - Viral Envelope Proteins/metabolism
MH  - Virion/metabolism
MH  - *Virus Assembly
PMC - PMC6506506
COIS- The authors declare no competing interests.
EDAT- 2019/05/10 06:00
MHDA- 2019/06/14 06:00
PMCR- 2019/05/08
CRDT- 2019/05/10 06:00
PHST- 2018/07/19 00:00 [received]
PHST- 2019/04/22 00:00 [accepted]
PHST- 2019/05/10 06:00 [entrez]
PHST- 2019/05/10 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/05/08 00:00 [pmc-release]
AID - 10.1038/s41467-019-10117-z [pii]
AID - 10117 [pii]
AID - 10.1038/s41467-019-10117-z [doi]
PST - epublish
SO  - Nat Commun. 2019 May 8;10(1):2098. doi: 10.1038/s41467-019-10117-z.