PMID- 31071930
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 5
DP  - 2019 May 8
TI  - Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review 
      and Meta-Analysis.
LID - 10.3390/nu11051027 [doi]
LID - 1027
AB  - Zinc could have a protective role against type 2 diabetes mellitus (T2DM). This 
      systematic review and meta-analysis aimed to evaluate the association between 
      dietary, supplementary, and total zinc intake, as well as serum/plasma and whole 
      blood zinc concentration, and risk of T2DM. Observational studies, conducted on 
      cases of incident diabetes or T2DM patients and healthy subjects that reported a 
      measure of association between zinc exposure and T2DM, were selected. Random 
      effects meta-analyses were applied to obtain combined results. Stratified 
      meta-analyses and meta-regressions were executed to assess sources of 
      heterogeneity, as well as the impact of covariates on the findings. From 12,136 
      publications, 16 studies were selected. The odds ratio (OR) for T2DM comparing 
      the highest versus lowest zinc intake from diet was 0.87 (95% CI: 0.78-0.98). 
      Nevertheless, no association between supplementary or total zinc intake from both 
      diet and supplementation, and T2DM was observed. A direct relationship was found 
      between serum/plasma zinc levels and T2DM (OR = 1.64, 95% CI: 1.25-2.14). A 
      moderately high dietary zinc intake, in relation to the Dietary Reference Intake, 
      could reduce by 13% the risk of T2DM, and up to 41% in rural areas. Conversely, 
      elevated serum/plasma zinc concentration was associated with an increased risk of 
      T2DM by 64%, suggesting disturbances in zinc homeostasis.
FAU - Fernandez-Cao, Jose C
AU  - Fernandez-Cao JC
AUID- ORCID: 0000-0002-1697-3443
AD  - Department of Nutrition and Dietetics, Faculty of Heath Sciences, University of 
      Atacama, Av. Copayapu 2862, Copiapo, 1530000 Atacama Region, Chile. 
      jose.fernandez.cao@uda.cl.
AD  - Nutrition and Public Health, Universitat Rovira i Virgili, C/ Sant Llorenc 21, 
      Reus, 43201 Tarragona, Spain. jose.fernandez.cao@uda.cl.
FAU - Warthon-Medina, Marisol
AU  - Warthon-Medina M
AUID- ORCID: 0000-0003-1318-397X
AD  - Food Databanks National Capability, Quadram Institute Bioscience, Norwich 
      Research Park, Norwich, Norfolk NR4 7UA, UK. marisol@warthon-medina.com.
AD  - International Institute of Nutritional Sciences and Food Safety Studies, 
      University of Central Lancashire, Darwin Building c/o Psychology Scholl Office, 
      Preston, Lancashire PR1 2HE, UK. marisol@warthon-medina.com.
FAU - H Moran, Victoria
AU  - H Moran V
AD  - Maternal and Infant Nutrition and Nurture Unit, University of Central Lancashire, 
      Preston, Lancashire PR 1 2HE, UK. VLMoran@uclan.ac.uk.
FAU - Arija, Victoria
AU  - Arija V
AD  - Research Group in Nutrition and Mental Health (NUTRISAM), Institut d'Investigacio 
      Sanitaria Pere Virgili (IISPV), Rovira i Virgili University, Reus, 43201 
      Tarragona, Spain. victoria.arija@urv.cat.
FAU - Doepking, Carlos
AU  - Doepking C
AUID- ORCID: 0000-0001-6281-2686
AD  - Department of Nutrition and Dietetics, Faculty of Heath Sciences, University of 
      Atacama, Av. Copayapu 2862, Copiapo, 1530000 Atacama Region, Chile. 
      carlos.doepking@uda.cl.
FAU - Serra-Majem, Lluis
AU  - Serra-Majem L
AUID- ORCID: 0000-0002-9658-9061
AD  - Research Institute of Biomedical and Health Sciences, University of Las Palmas de 
      Gran Canaria and CHUIMI, Canarian Health Service, 35016 Las Palmas de Gran 
      Canaria, Spain. lluis.serra@ulpgc.es.
AD  - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBERObn), 
      Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. 
      lluis.serra@ulpgc.es.
FAU - Lowe, Nicola M
AU  - Lowe NM
AUID- ORCID: 0000-0002-6934-2768
AD  - International Institute of Nutritional Sciences and Food Safety Studies, 
      University of Central Lancashire, Darwin Building c/o Psychology Scholl Office, 
      Preston, Lancashire PR1 2HE, UK. NMLowe@uclan.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190508
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*etiology
MH  - Humans
MH  - *Nutritional Status
MH  - Odds Ratio
MH  - Risk Factors
MH  - Zinc/*administration & dosage/blood
PMC - PMC6567047
OTO - NOTNLM
OT  - epidemiology
OT  - meta-analysis
OT  - systematic review
OT  - trace elements
OT  - type 2 diabetes mellitus
OT  - zinc intake
OT  - zinc status
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/11 06:00
MHDA- 2020/01/07 06:00
PMCR- 2019/05/01
CRDT- 2019/05/11 06:00
PHST- 2019/03/26 00:00 [received]
PHST- 2019/04/23 00:00 [revised]
PHST- 2019/04/25 00:00 [accepted]
PHST- 2019/05/11 06:00 [entrez]
PHST- 2019/05/11 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - nu11051027 [pii]
AID - nutrients-11-01027 [pii]
AID - 10.3390/nu11051027 [doi]
PST - epublish
SO  - Nutrients. 2019 May 8;11(5):1027. doi: 10.3390/nu11051027.