PMID- 31073300
OWN - NLM
STAT- MEDLINE
DCOM- 20200721
LR  - 20200721
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Metabolic Control of Dendritic Cell Functions: Digesting Information.
PG  - 775
LID - 10.3389/fimmu.2019.00775 [doi]
LID - 775
AB  - Dendritic cells (DCs) control innate and adaptive immunity by patrolling tissues 
      to gather antigens and danger signals derived from microbes and tissue. 
      Subsequently, DCs integrate those environmental cues, orchestrate immunity or 
      tolerance, and regulate tissue homeostasis. Recent advances in the field of 
      immunometabolism highlight the notion that immune cells markedly alter cellular 
      metabolic pathways during differentiation or upon activation, which has important 
      implications on their functionality. Previous studies showed that active 
      oxidative phosphorylation in mitochondria is associated with immature or 
      tolerogenic DCs, while increased glycolysis upon pathogen sensing can promote 
      immunogenic DC functions. However, new results in the last years suggest that 
      regulation of DC metabolism in steady state, after immunogenic activation and 
      during tolerance in different pathophysiological settings, may be more complex. 
      Moreover, ontogenically distinct DC subsets show different functional 
      specializations to control T cell responses. It is, thus, relevant how metabolism 
      influences DC differentiation and plasticity, and what potential metabolic 
      differences exist among DC subsets. Better understanding of the emerging 
      connection between metabolic adaptions and functional DC specification will 
      likely allow the development of therapeutic strategies to manipulate immune 
      responses.
FAU - Wculek, Stefanie K
AU  - Wculek SK
AD  - Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares 
      (CNIC), Madrid, Spain.
FAU - Khouili, Sofia C
AU  - Khouili SC
AD  - Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares 
      (CNIC), Madrid, Spain.
FAU - Priego, Elena
AU  - Priego E
AD  - Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares 
      (CNIC), Madrid, Spain.
FAU - Heras-Murillo, Ignacio
AU  - Heras-Murillo I
AD  - Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares 
      (CNIC), Madrid, Spain.
FAU - Sancho, David
AU  - Sancho D
AD  - Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares 
      (CNIC), Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190425
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Animals
MH  - Cell Differentiation/immunology/physiology
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Oxidative Phosphorylation
MH  - T-Lymphocytes/immunology/metabolism
PMC - PMC6496459
OTO - NOTNLM
OT  - AMP-activated protein kinase
OT  - DC subsets
OT  - dendritic cell
OT  - glycolysis
OT  - hypoxia-inducible factor
OT  - mammalian target of rapamycin
OT  - metabolism
OT  - mitochondria
EDAT- 2019/05/11 06:00
MHDA- 2020/07/22 06:00
PMCR- 2019/01/01
CRDT- 2019/05/11 06:00
PHST- 2018/11/07 00:00 [received]
PHST- 2019/03/25 00:00 [accepted]
PHST- 2019/05/11 06:00 [entrez]
PHST- 2019/05/11 06:00 [pubmed]
PHST- 2020/07/22 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.00775 [doi]
PST - epublish
SO  - Front Immunol. 2019 Apr 25;10:775. doi: 10.3389/fimmu.2019.00775. eCollection 
      2019.