PMID- 31073438
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2146-4618 (Print)
IS  - 2146-4626 (Electronic)
IS  - 2146-4626 (Linking)
VI  - 6
IP  - 2
DP  - 2017 Jun
TI  - Guiding Antiepileptic Therapy in a Pediatric Patient with Severe 
      Meningoencephalitis and Decompressive Craniectomy with the Use of 
      Amplitude-Integrated Electroencephalography.
PG  - 136-141
LID - 10.1055/s-0036-1587328 [doi]
AB  - Introduction Amplitude-integrated electroencephalography (aEEG) is one of the 
      most widely used neuromonitoring tools in neonatology today. However, little is 
      known about its clinical indications and potential benefits in pediatric 
      intensive care patients. Based on limited experience, its impact on therapeutic 
      decision-making in this patient population is unclear. Case Description We report 
      the case of a 16-year-old boy who, after a pansinusitis, developed a severe 
      meningoencephalitis and intracranial empyema with increased intracranial pressure 
      that required drainage and decompressive craniectomy. He subsequently developed 
      status epilepticus despite a combination of various anticonvulsants. Only after 
      the initialization of an aEEG, we were able to adequately diagnose and 
      continuously monitor his seizure activity and titrate the effect of the 
      antiepileptic drugs. During his hospital stay, we were able to clearly monitor 
      and guide our therapy by accurately identifying the termination of status 
      epilepticus and the recurrence of seizures. Discussion With the help of aEEG, it 
      was easy to identify the nonconvulsive status epilepticus (NCSE) and the ongoing 
      seizure activity in this teenage patient. NCSE is a clinical problem with an 
      effect on the outcome of the patient and is often underdiagnosed. AEEG enabled a 
      rapid detection and management of seizure activity and thereby reduced the 
      overall seizure burden, which was associated with better neurologic outcome.
FAU - Schettler, Karl F
AU  - Schettler KF
AD  - Department of Pediatric Cardiology and Pediatric Intensive Care, Campus 
      Grosshadern of the Ludwig Maximilians University, Munich, Germany.
FAU - Heineking, Beatrice
AU  - Heineking B
AD  - Department of Pediatric Cardiology and Pediatric Intensive Care, Campus 
      Grosshadern of the Ludwig Maximilians University, Munich, Germany.
FAU - Fernandez-Rodriguez, Silvia
AU  - Fernandez-Rodriguez S
AD  - Department of Pediatric Cardiology and Pediatric Intensive Care, Campus 
      Grosshadern of the Ludwig Maximilians University, Munich, Germany.
FAU - Pilger, Angelika
AU  - Pilger A
AD  - Department of Pediatric Cardiology and Pediatric Intensive Care, Campus 
      Grosshadern of the Ludwig Maximilians University, Munich, Germany.
FAU - Haas, Nikolaus Alexander
AU  - Haas NA
AD  - Department of Pediatric Cardiology and Pediatric Intensive Care, Campus 
      Grosshadern of the Ludwig Maximilians University, Munich, Germany.
LA  - eng
PT  - Case Reports
DEP - 20160808
PL  - Germany
TA  - J Pediatr Intensive Care
JT  - Journal of pediatric intensive care
JID - 101592756
PMC - PMC6260291
OTO - NOTNLM
OT  - amplitude-integrated EEG
OT  - antiepileptic therapy
OT  - meningoencephalitis
OT  - neuromonitoring
OT  - nonconvulsive status epilepticus
EDAT- 2017/06/01 00:00
MHDA- 2017/06/01 00:01
PMCR- 2017/06/01
CRDT- 2019/05/11 06:00
PHST- 2016/04/03 00:00 [received]
PHST- 2016/07/01 00:00 [accepted]
PHST- 2019/05/11 06:00 [entrez]
PHST- 2017/06/01 00:00 [pubmed]
PHST- 2017/06/01 00:01 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 1600008 [pii]
AID - 10.1055/s-0036-1587328 [doi]
PST - ppublish
SO  - J Pediatr Intensive Care. 2017 Jun;6(2):136-141. doi: 10.1055/s-0036-1587328. 
      Epub 2016 Aug 8.