PMID- 31075380
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20221207
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 239
DP  - 2019 Jul 15
TI  - The Chinese herbal formulae (Yitangkang) exerts an antidiabetic effect through 
      the regulation of substance metabolism and energy metabolism in type 2 diabetic 
      rats.
PG  - 111942
LID - S0378-8741(19)30788-3 [pii]
LID - 10.1016/j.jep.2019.111942 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Type 2 diabetes mellitus (T2DM) regarded as a 
      "hot" disease in traditional Chinese medicine (TCM). Accordingly, TCM uses a cold 
      drug or formula such as the Chinese herbal formulae "Yitangkang" (YTK) as a 
      treatment. YTK exhibited a good clinical antidiabetic effect in several 
      experiments. The correlation between the properties of a TCM drug or formula and 
      its ability to regulate the substance metabolism, the energy metabolism and the 
      endocrine system has been proven. AIM OF THE STUDY: The present study aiming to 
      evaluate the mechanism of antidiabetic action of YTK from the above perspective. 
      MATERIALS AND METHODS: Three groups of streptozotocin (STZ)-diabetic rats have 
      been treated with YTK at oral doses of 56 g/kg/d, 28 g/kg/d and 14 g/kg/d for 28 
      days using metformin as a reference drug. After treatment, several indices 
      correlated with energy metabolism (superoxide dismutase, glutathione peroxidase, 
      lactic dehydrogenase, adenotriphos, creatine phosphate kinase, AMPK, 
      Na(+)-K(+)-ATPase and Respiratory Chain Complex I, II, III, IV), substance 
      metabolism (hepatic glycogen, acetyl-coenzyme A, pyruvic acid, adipose 
      triglyceride lipase, triglycerides, high-density lipoproteins, low-density 
      lipoproteins, malonyldialdehyde), endocrine system (triiodothyronine, thyroxine, 
      17-hydroxycorticosteroid) and cyclic nucleotide system (cyclic adenosine 
      monophosphate, cyclic guanosine monophosphate) have been determined. The 
      specialty and tendency of YTK's effects were analyzed to elucidate its property 
      and mechanism of action according to the theory of TCM. RESULTS: Our findings 
      showed that the formulae YTK could effectively regulate the levels of blood 
      glucose, HbA1c, glucagon-like peptide-1, and significantly down-regulate the 
      substance metabolism, energy metabolism and endocrine system indices of the 
      diabetic rats. CONCLUSION: These results were consistent with the TCM description 
      of YTK as a "cold" treatment. It could provide an effective way to interpret the 
      scientific connotation and comprehensive system of the Chinese herbal formulae.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Han, Xueying
AU  - Han X
AD  - College of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life 
      One Road, DD Port, Dalian, 116600, PR China.
FAU - Yang, Yufeng
AU  - Yang Y
AD  - College of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life 
      One Road, DD Port, Dalian, 116600, PR China.
FAU - Metwaly, Ahmed M
AU  - Metwaly AM
AD  - College of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life 
      One Road, DD Port, Dalian, 116600, PR China.
FAU - Xue, Yawei
AU  - Xue Y
AD  - College of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life 
      One Road, DD Port, Dalian, 116600, PR China.
FAU - Shi, Yan
AU  - Shi Y
AD  - College of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life 
      One Road, DD Port, Dalian, 116600, PR China. Electronic address: 
      446196375@qq.com.
FAU - Dou, Deqiang
AU  - Dou D
AD  - College of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life 
      One Road, DD Port, Dalian, 116600, PR China. Electronic address: 
      deqiangdou@126.com.
LA  - eng
PT  - Journal Article
DEP - 20190508
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Blood Glucose)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Thyroid Hormones)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - E0399OZS9N (Cyclic AMP)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Cyclic AMP/metabolism
MH  - Cyclic GMP/metabolism
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Energy Metabolism/drug effects
MH  - Glucagon-Like Peptide 1/metabolism
MH  - Glycated Hemoglobin/analysis
MH  - Hypoglycemic Agents/pharmacology/*therapeutic use
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - Myocardium/metabolism
MH  - Rats, Sprague-Dawley
MH  - Thyroid Hormones/metabolism
OTO - NOTNLM
OT  - Chinese herbal formulae
OT  - Energy metabolism
OT  - Substance metabolism
OT  - Type 2 diabetes mellitus
OT  - Yitangkang
EDAT- 2019/05/11 06:00
MHDA- 2020/01/07 06:00
CRDT- 2019/05/11 06:00
PHST- 2019/02/27 00:00 [received]
PHST- 2019/05/04 00:00 [revised]
PHST- 2019/05/06 00:00 [accepted]
PHST- 2019/05/11 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/05/11 06:00 [entrez]
AID - S0378-8741(19)30788-3 [pii]
AID - 10.1016/j.jep.2019.111942 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2019 Jul 15;239:111942. doi: 10.1016/j.jep.2019.111942. Epub 
      2019 May 8.