PMID- 31075437
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20191217
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 565
DP  - 2019 Jun 30
TI  - Managing efficacy and toxicity of drugs: Targeted delivery and excretion.
PG  - 378-390
LID - S0378-5173(19)30321-7 [pii]
LID - 10.1016/j.ijpharm.2019.04.058 [doi]
AB  - Medicine is a natural companion of mankind in the present era for mere survival 
      from the deadly diseases in ever-increasing polluted environments. Hence, in 
      recent years, major focus of pharmaceutical, medicinal and biophysical research 
      has been navigated in exploring and developing new and simple avenues to enhance 
      the efficacy of the administered drugs on one hand and to get rid of, or at least 
      reduce, the toxic side effects of the excess drugs accumulated in human body on 
      the other. A potential approach to amplify the efficacy of the administered drug 
      is to develop proficient targeted drug delivery systems (DDSs). This review 
      provides an essence of some newly developed simple but prospective strategies on 
      enhancing the efficacy of drugs/bioactive molecules exploiting various drug 
      delivery systems like micelles, cyclodextrins, liposomes etc. to serve the 
      purpose of targeted delivery towards DNA, by endogenous and/or exogenous means. 
      Improved bio-availability and solubilization of ionic drugs within the less polar 
      target regions from the bulk aqueous phase has also been achieved through the 
      introduction of some physiologically permissible salts. In the other context, in 
      vitro and in vivo studies demonstrate a simple technique for easy removal of the 
      excess adsorbed drug molecules from the cell membranes/lipid bilayers by 
      exploiting health-amiable supramolecular assemblies. In this review, we summarize 
      the recent experimental findings, mostly from our lab, encompassing the 
      development of simple biocompatible methods to enhance the benevolent role of 
      drugs through their safe, effective and convenient administration. It also 
      presents easy and effective means to remove the excess adsorbed drugs from human 
      body to diminish their malign effects. These prospective approaches of drug 
      delivery and excretion of drug molecules have promising roles to play from both 
      physicochemical and pharmaceutical perspectives, ensuring enhanced 
      bioavailability of drugs as well as disposing of drug-induced adverse side 
      effects.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Kundu, Pronab
AU  - Kundu P
AD  - Department of Chemistry, Jadavpur University, Kolkata 700 032, India.
FAU - Das, Sinjan
AU  - Das S
AD  - Department of Chemistry, Jadavpur University, Kolkata 700 032, India.
FAU - Chattopadhyay, Nitin
AU  - Chattopadhyay N
AD  - Department of Chemistry, Jadavpur University, Kolkata 700 032, India. Electronic 
      address: nitin.chattopadhyay@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190507
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Drug Therapy
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - Pharmaceutical Preparations/administration & dosage/chemistry/metabolism
MH  - Solubility
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Bioactive small molecules
OT  - Drug delivery systems
OT  - Drug excretion
OT  - Drug solubilization
OT  - Targeted drug delivery
EDAT- 2019/05/11 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/05/11 06:00
PHST- 2019/03/20 00:00 [received]
PHST- 2019/04/17 00:00 [revised]
PHST- 2019/04/19 00:00 [accepted]
PHST- 2019/05/11 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/05/11 06:00 [entrez]
AID - S0378-5173(19)30321-7 [pii]
AID - 10.1016/j.ijpharm.2019.04.058 [doi]
PST - ppublish
SO  - Int J Pharm. 2019 Jun 30;565:378-390. doi: 10.1016/j.ijpharm.2019.04.058. Epub 
      2019 May 7.