PMID- 31075682
OWN - NLM
STAT- MEDLINE
DCOM- 20200720
LR  - 20200720
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 401
DP  - 2019 Jun 15
TI  - Nocebo in cerebellar ataxia: A systematic review and meta-analysis of 
      placebo-controlled clinical trials.
PG  - 112-117
LID - S0022-510X(19)30206-0 [pii]
LID - 10.1016/j.jns.2019.04.039 [doi]
AB  - INTRODUCTION: Nocebo, the negative counterpart of the placebo phenomenon results 
      in the induction of adverse events (AEs) following the administration of an inert 
      substance. Nocebo has been demonstrated to be associated with low treatment 
      compliance in clinical trials, thus affecting treatment outcomes. This study 
      sought to determine the prevalence of nocebo in cerebellar ataxia. METHODS: A 
      systematic literature search was conducted on Pubmed for randomized controlled 
      trials (RCTs) for cerebellar ataxia treatments. The number of drug-related AEs 
      and the number of withdrawals due to drug intolerance in the placebo group were 
      statistically analysed. RESULTS: The literature search identified 214 studies, of 
      which 6 studies fulfilled the inclusion criteria. Approximately 1 in 20 (4.8%) 
      placebo-treated patients withdrew treatment due to AEs and approximately 1 in 7 
      (13.8%) placebo-treated participants reported at least one AE. Participants in 
      cerebellar ataxia trials reported similar AEs across both treatment groups 
      (active and placebo). CONCLUSION: Our results demonstrate that the nocebo effect 
      in cerebellar ataxia is amongst the lowest in neurological diseases.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Alam, Jawwaria M
AU  - Alam JM
AD  - Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation 
      Trust, UK; Sheffield Institute for Translational Neuroscience, Sheffield, UK. 
      Electronic address: jalam1@sheffield.ac.uk.
FAU - Hadjivassiliou, Marios
AU  - Hadjivassiliou M
AD  - Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation 
      Trust, UK. Electronic address: m.hadjivassiliou@sheffield.ac.uk.
FAU - Zis, Panagiotis
AU  - Zis P
AD  - Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation 
      Trust, UK; Sheffield Institute for Translational Neuroscience, Sheffield, UK; 
      Medical School, University of Cyprus, Nicosia, Cyprus. Electronic address: 
      takiszis@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190430
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Cerebellar Ataxia/*drug therapy
MH  - Humans
MH  - *Nocebo Effect
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
EDAT- 2019/05/11 06:00
MHDA- 2020/07/21 06:00
CRDT- 2019/05/11 06:00
PHST- 2019/03/05 00:00 [received]
PHST- 2019/04/08 00:00 [revised]
PHST- 2019/04/29 00:00 [accepted]
PHST- 2019/05/11 06:00 [pubmed]
PHST- 2020/07/21 06:00 [medline]
PHST- 2019/05/11 06:00 [entrez]
AID - S0022-510X(19)30206-0 [pii]
AID - 10.1016/j.jns.2019.04.039 [doi]
PST - ppublish
SO  - J Neurol Sci. 2019 Jun 15;401:112-117. doi: 10.1016/j.jns.2019.04.039. Epub 2019 
      Apr 30.