PMID- 31076186 OWN - NLM STAT- MEDLINE DCOM- 20200807 LR - 20200807 IS - 1873-7862 (Electronic) IS - 0924-977X (Linking) VI - 29 IP - 6 DP - 2019 Jun TI - Functional remediation improves bipolar disorder functioning with no effects on brain-derived neurotrophic factor levels. PG - 701-710 LID - S0924-977X(19)30233-0 [pii] LID - 10.1016/j.euroneuro.2019.04.002 [doi] AB - The main aim of this study is to evaluate the impact of functional remediation (FR) in serum brain derived neurotrophic factor (BDNF) levels in euthymic adult patients with Bipolar Disorder (BD). A total of 128 participants were recruited at the Hospital Clinic of Barcelona. They were assessed at baseline and at the end of follow-up by the means of Hamilton Depression Scale (HAM-D), Young Mania Rating Scale (YMRS) and Functioning Assessment Short Test (FAST), as well as a clinical structured interview to collect clinical and demographic variables of interest. Blood samples were also collected to assess BDNF levels. After baseline assessment, patients received FR, Psychoeducation or treatment as usual (TAU). One hundred and two out of 126 participants finished the study distributed as follows: FR group (n = 39); Psychoeducation group (n = 47) and TAU group (n = 16). Longitudinal repeated-measures analyses addressing the treatment effect on BDNF levels showed non-significant differences between the three groups (Pillai's trace = 0.06; F((2,97))= 0.28; p = 0.75), suggesting no interaction between treatment allocation and time on BDNF levels. The results of this study suggest that FR has no effect on peripheral BDNF levels in euthymic patients with BD, despite the improvement in psychosocial functioning. CI - Copyright (c) 2019. Published by Elsevier B.V. FAU - Bonnin, Caterina Del Mar AU - Bonnin CDM AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Valls, Elia AU - Valls E AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Rosa, Adriane R AU - Rosa AR AD - Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - Reinares, Maria AU - Reinares M AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Jimenez, Esther AU - Jimenez E AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Sole, Brisa AU - Sole B AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Montejo, Laura AU - Montejo L AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Meseguer, Ana AU - Meseguer A AD - Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, Catalonia, Spain. FAU - Pacchiarotti, Isabella AU - Pacchiarotti I AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Colom, Francesc AU - Colom F AD - Mental Health Group, IMIM (Institut Hospital del Mar d'Investigacions Mediques)-Hospital del Mar, CIBERSAM, Barcelona, Catalonia, Spain. FAU - Martinez-Aran, Anabel AU - Martinez-Aran A AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. Electronic address: amartiar@clinic.ub.es. FAU - Tomioka, Yoko AU - Tomioka Y AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Vieta, Eduard AU - Vieta E AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. FAU - Torrent, Carla AU - Torrent C AD - Barcelona Bipolar and Depressive Disorders Program, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Hospital Clinic of Barcelona, Catalonia, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190507 PL - Netherlands TA - Eur Neuropsychopharmacol JT - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JID - 9111390 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adolescent MH - Adult MH - Affect MH - Aged MH - Bipolar Disorder/*metabolism/psychology/*therapy MH - Brain-Derived Neurotrophic Factor/*blood MH - Cognitive Behavioral Therapy MH - Diagnostic and Statistical Manual of Mental Disorders MH - Female MH - Follow-Up Studies MH - Humans MH - Longitudinal Studies MH - Male MH - Middle Aged MH - Neuropsychological Tests MH - Patient Education as Topic MH - Psychiatric Status Rating Scales MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - BDNF OT - Bipolar disorder OT - Functional remediation OT - Functioning OT - Psychoeducation EDAT- 2019/05/12 06:00 MHDA- 2020/08/08 06:00 CRDT- 2019/05/12 06:00 PHST- 2018/10/18 00:00 [received] PHST- 2019/04/01 00:00 [revised] PHST- 2019/04/23 00:00 [accepted] PHST- 2019/05/12 06:00 [pubmed] PHST- 2020/08/08 06:00 [medline] PHST- 2019/05/12 06:00 [entrez] AID - S0924-977X(19)30233-0 [pii] AID - 10.1016/j.euroneuro.2019.04.002 [doi] PST - ppublish SO - Eur Neuropsychopharmacol. 2019 Jun;29(6):701-710. doi: 10.1016/j.euroneuro.2019.04.002. Epub 2019 May 7.