PMID- 31078448
OWN - NLM
STAT- MEDLINE
DCOM- 20200306
LR  - 20231012
IS  - 2210-7762 (Print)
VI  - 235-236
DP  - 2019 Jun
TI  - Uptake of genetic testing for germline BRCA1/2 pathogenic variants in a 
      predominantly Hispanic population.
PG  - 72-76
LID - S2210-7762(19)30059-6 [pii]
LID - 10.1016/j.cancergen.2019.04.063 [doi]
AB  - Genetic counseling is under-utilized in women who meet family history criteria 
      for BRCA1 and BRCA2 (BRCA1/2) testing, particularly among racial/ethnic 
      minorities. We evaluated the uptake of BRCA1/2 genetic testing among women 
      presenting for screening mammography in a predominantly Hispanic, low-income 
      population of Washington Heights in New York City. We administered the Six-Point 
      Scale (SPS) to women presenting for screening mammography at Columbia University 
      Irving Medical Center (CUIMC) in the Washington Heights neighborhood of New York, 
      NY. The SPS is a family history screener to determine eligibility for BRCA1/2 
      genetic testing based upon U.S. Preventive Services Task Force (USPSTF) 
      guidelines that has been validated in low-income, multiethnic populations. Among 
      women who underwent screening mammography at CUIMC between November 2014 and June 
      2016, 3,055 completed the SPS family history screener. Participants were 
      predominantly Hispanic (76.7%), and 12% met family history criteria for BRCA1/2 
      testing, of whom <5% had previously undergone testing. In a multiethnic 
      population, a significant proportion met family history criteria for BRCA1/2 
      testing, but uptake of genetic testing was low. Such underutilization of BRCA1/2 
      genetic testing among minorities further underscores the need to develop programs 
      to engage high-risk women from underrepresented populations in genetic testing 
      services.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - McGuinness, Julia E
AU  - McGuinness JE
AD  - Department of Medicine, Division of Hematology and Oncology, College of 
      Physicians and Surgeons, Columbia University, 177 Fort Washington Avenue, Suite 
      6GN-435, New York, NY 10032, United States. Electronic address: 
      jem2280@cumc.columbia.edu.
FAU - Trivedi, Meghna S
AU  - Trivedi MS
AD  - Department of Medicine, Division of Hematology and Oncology, College of 
      Physicians and Surgeons, Columbia University, 177 Fort Washington Avenue, Suite 
      6GN-435, New York, NY 10032, United States.
FAU - Silverman, Thomas
AU  - Silverman T
AD  - Department of Biomedical Informatics, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, United States.
FAU - Marte, Awilda
AU  - Marte A
AD  - Department of Medicine, Division of Hematology and Oncology, College of 
      Physicians and Surgeons, Columbia University, 177 Fort Washington Avenue, Suite 
      6GN-435, New York, NY 10032, United States.
FAU - Mata, Jennie
AU  - Mata J
AD  - Department of Medicine, Division of Hematology and Oncology, College of 
      Physicians and Surgeons, Columbia University, 177 Fort Washington Avenue, Suite 
      6GN-435, New York, NY 10032, United States.
FAU - Kukafka, Rita
AU  - Kukafka R
AD  - Department of Biomedical Informatics, College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, United States.
FAU - Crew, Katherine D
AU  - Crew KD
AD  - Department of Medicine, Division of Hematology and Oncology, College of 
      Physicians and Surgeons, Columbia University, 177 Fort Washington Avenue, Suite 
      6GN-435, New York, NY 10032, United States.
LA  - eng
GR  - KL2 TR001874/TR/NCATS NIH HHS/United States
GR  - P30 CA013696/CA/NCI NIH HHS/United States
GR  - U01 HG008680/HG/NHGRI NIH HHS/United States
GR  - UL1 TR000040/TR/NCATS NIH HHS/United States
GR  - R01 CA177995/CA/NCI NIH HHS/United States
GR  - R01 CA226060/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190424
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
RN  - 0 (BRCA1 Protein)
RN  - 0 (BRCA1 protein, human)
RN  - 0 (BRCA2 Protein)
RN  - 0 (BRCA2 protein, human)
SB  - IM
MH  - BRCA1 Protein/*genetics
MH  - BRCA2 Protein/*genetics
MH  - Breast Neoplasms/*genetics
MH  - Female
MH  - Genetic Counseling/*statistics & numerical data
MH  - Genetic Testing/*statistics & numerical data
MH  - Hispanic or Latino/genetics/statistics & numerical data
MH  - Humans
MH  - Mammography
MH  - Minority Groups/statistics & numerical data
MH  - New York City
PMC - PMC6625883
MID - NIHMS1528953
OTO - NOTNLM
OT  - BRCA1/BRCA2 genetic testing
OT  - Family history
OT  - Hereditary breast and ovarian cancer
OT  - Racial/ethnic minorities
COIS- Declarations of interest: none
EDAT- 2019/05/13 06:00
MHDA- 2020/03/07 06:00
PMCR- 2020/06/01
CRDT- 2019/05/13 06:00
PHST- 2019/02/05 00:00 [received]
PHST- 2019/04/10 00:00 [revised]
PHST- 2019/04/18 00:00 [accepted]
PHST- 2019/05/13 06:00 [pubmed]
PHST- 2020/03/07 06:00 [medline]
PHST- 2019/05/13 06:00 [entrez]
PHST- 2020/06/01 00:00 [pmc-release]
AID - S2210-7762(19)30059-6 [pii]
AID - 10.1016/j.cancergen.2019.04.063 [doi]
PST - ppublish
SO  - Cancer Genet. 2019 Jun;235-236:72-76. doi: 10.1016/j.cancergen.2019.04.063. Epub 
      2019 Apr 24.