PMID- 31079089
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 9
IP  - 5
DP  - 2019 May 10
TI  - Levels of Lipoprotein (a) in patients with coronary artery disease with and 
      without inflammatory rheumatic disease: a cross-sectional study.
PG  - e030651
LID - 10.1136/bmjopen-2019-030651 [doi]
LID - e030651
AB  - OBJECTIVES: Patients with various inflammatory rheumatic diseases (IRDs) have 
      increased risk of atherothrombotic disease. Lipoprotein (a) (Lp(a)) is a risk 
      factor for atherosclerosis but its role in IRD with accompanying coronary artery 
      disease (CAD) is still unclear. We aimed to examine if serum Lp(a) levels 
      differed between CAD patients with and without accompanying IRD. DESIGN: A 
      cross-sectional observational, patient-based cohort study. SETTING: Referred 
      centre for coronary artery bypass grafting in the South Eastern part of Norway. 
      PARTICIPANTS: 67 CAD patients with IRD (CAD/IRD) and 52 CAD patients without IRD 
      (CAD/non-IRD). All patients were Caucasians, aged >18 years, without any 
      clinically significant infection or malignancy. METHODS: Lp(a) levels in serum 
      were analysed by particle enhanced immunoturbidimetric assay, and Lp(a) levels 
      were related to clinical and biochemical characteristics of the patient 
      population. RESULTS: We found no differences in serum levels of Lp(a) between CAD 
      patients with and without IRD. In general, we found that Lp(a) correlated poorly 
      with clinical and biochemical parameters including C reactive protein with the 
      same pattern in the CAD/non-IRD and CAD/IRD groups. CONCLUSIONS: Our data do not 
      support a link between inflammation and Lp(a) levels in CAD and in general Lp(a) 
      levels were not correlated with other risk factors for cardiovascular disease.
CI  - (c) Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Holm, Sverre
AU  - Holm S
AD  - Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
AD  - Rheumatology Department, Hospital for Rheumatic Diseases, Lillehammer, Norway.
FAU - Oma, Ingvild
AU  - Oma I
AD  - Department of Pathology, Sykehuset Innlandet HF Divisjon Lillehammer, 
      Lillehammer, Norway.
AD  - Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Hagve, Tor-Arne
AU  - Hagve TA
AD  - Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Division of Diagnostics and Technology, Akershus University Hospital, Lorenskog, 
      Norway.
FAU - Saatvedt, Kjell
AU  - Saatvedt K
AD  - Department of Thoracic Surgery, Oslo University Hospital Rikshospitalet, Oslo, 
      Norway.
FAU - Brosstad, Frank
AU  - Brosstad F
AD  - Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
AD  - Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Mikkelsen, Knut
AU  - Mikkelsen K
AD  - Rheumatology Department, Hospital for Rheumatic Diseases, Lillehammer, Norway.
FAU - Rydningen, Hans
AU  - Rydningen H
AD  - Department of Cardiac Surgery, Feiring Heart Clinic, Feiring, Norway.
FAU - Risnes, Ivar
AU  - Risnes I
AD  - Department of Cardiac Surgery, Feiring Heart Clinic, Feiring, Norway.
FAU - Almdahl, Sven Martin
AU  - Almdahl SM
AD  - Department of Cardiothoracic and Vascular Surgery, University Hospital of North 
      Norway, Tromso, Norway.
FAU - Ueland, Thor
AU  - Ueland T
AD  - Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
AD  - Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Aukrust, Pal
AU  - Aukrust P
AD  - Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
AD  - Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital 
      Rikshospitalet, Oslo, Norway.
FAU - Halvorsen, Bente
AU  - Halvorsen B
AD  - Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
AD  - Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Hollan, Ivana
AU  - Hollan I
AD  - Rheumatology Department, Hospital for Rheumatic Diseases, Lillehammer, Norway.
AD  - Department of Pathology, Sykehuset Innlandet HF Divisjon Lillehammer, 
      Lillehammer, Norway.
AD  - Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
AD  - Harvard Medical School, Harvard, Boston, USA.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20190510
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 0 (Lipoprotein(a))
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Coronary Artery Disease/*blood/complications
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Inflammation/blood/complications
MH  - Lipoprotein(a)/*blood
MH  - Male
MH  - Middle Aged
MH  - Rheumatic Diseases/*blood/complications
MH  - Risk Factors
PMC - PMC6530453
OTO - NOTNLM
OT  - atherosclerosis
OT  - coronary heart disease
OT  - rheumatology
COIS- Competing interests: None declared.
EDAT- 2019/05/13 06:00
MHDA- 2020/05/19 06:00
PMCR- 2019/05/10
CRDT- 2019/05/13 06:00
PHST- 2019/05/13 06:00 [entrez]
PHST- 2019/05/13 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/05/10 00:00 [pmc-release]
AID - bmjopen-2019-030651 [pii]
AID - 10.1136/bmjopen-2019-030651 [doi]
PST - epublish
SO  - BMJ Open. 2019 May 10;9(5):e030651. doi: 10.1136/bmjopen-2019-030651.