PMID- 31080166
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20210702
IS  - 1879-4076 (Electronic)
IS  - 1879-4068 (Linking)
VI  - 11
IP  - 3
DP  - 2020 Apr
TI  - Age-related cytokine effects on cancer-related fatigue and quality of life in 
      acute myeloid leukemia.
PG  - 402-409
LID - S1879-4068(18)30472-7 [pii]
LID - 10.1016/j.jgo.2019.04.009 [doi]
AB  - OBJECTIVES: We determined whether cytokines are a potential target to improve 
      cancer-related fatigue (CRF) and quality of life (QOL) in acute myeloid leukemia 
      (AML). METHODS: 219 patients age 18+ undergoing intensive chemotherapy for AML 
      were assessed at up to 4 time points (pre-treatment, 1 month, 6 months, 
      12 months). CRF and QOL were assessed with validated patient-reported outcome 
      measures with minimum clinically important differences (MCID) of 4 and 10 points, 
      respectively. A panel of 31 plasma cytokines was measured. CRF and QOL were 
      regressed against scaled cytokine values, adjusting for age, gender, time, 
      remission status, and hemoglobin in linear models. RESULTS: 498 cytokine samples 
      were available. For CRF, the model R(2) was 25.3%, with cytokines explaining 6.9% 
      of the variance. For QOL, corresponding values were 27.9% and 7.4%, respectively. 
      A shift from the 30th to 70th centile distribution of all cytokines was 
      associated with an improvement in CRF by 5.2 points and a 10.2-point improvement 
      in QOL. A shift from 5th to 95th centile in TNF-alpha but no other single cytokine 
      was associated with a change of >MCID in CRF, but there was no similar 
      association with QOL. Cytokines had greater explanatory power for CRF in older 
      versus younger adults and the most influential cytokines differed by age, 
      particularly TNF-alpha. CONCLUSION: Cytokines explain a relatively small amount of 
      CRF and QOL scores in patients with AML and effects differ by age group. For 
      cytokine-targeted therapies to improve either outcome, multiple cytokines may 
      need to be substantially altered and therapeutic targets may vary with age.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Alibhai, Shabbir M H
AU  - Alibhai SMH
AD  - Department of Medicine, University Health Network, Toronto, Canada; Department of 
      Medicine, University of Toronto, Toronto, Canada; Institute of Health Policy, 
      Management, and Evaluation, University of Toronto, Toronto, Canada. Electronic 
      address: shabbir.alibhai@uhn.ca.
FAU - Breunis, Henriette
AU  - Breunis H
AD  - Department of Medicine, University Health Network, Toronto, Canada.
FAU - Matelski, John
AU  - Matelski J
AD  - Department of Medicine, University Health Network, Toronto, Canada; Biostatistics 
      Research Unit, University Health Network, Toronto, Canada.
FAU - Timilshina, Narhari
AU  - Timilshina N
AD  - Department of Medicine, University Health Network, Toronto, Canada.
FAU - Kundra, Arjun
AU  - Kundra A
AD  - Department of Psychiatry, University Health Network, Toronto, Canada.
FAU - Lee, Chieh-Hsin
AU  - Lee CH
AD  - Division of Neurology, Department of Medicine, University of Alberta, Edmonton, 
      Canada.
FAU - Li, Madeline
AU  - Li M
AD  - Department of Psychiatry, University Health Network, Toronto, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190510
PL  - Netherlands
TA  - J Geriatr Oncol
JT  - Journal of geriatric oncology
JID - 101534770
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Cytokines
MH  - Fatigue/etiology
MH  - Humans
MH  - *Leukemia, Myeloid, Acute/complications/drug therapy
MH  - Patient Reported Outcome Measures
MH  - *Quality of Life
OTO - NOTNLM
OT  - Acute myeloid leukemia
OT  - Aging
OT  - Cancer-related fatigue
OT  - Cytokines
OT  - Interleukin
OT  - Quality of life
OT  - Tumor necrosis factor
EDAT- 2019/05/14 06:00
MHDA- 2021/07/03 06:00
CRDT- 2019/05/14 06:00
PHST- 2018/11/27 00:00 [received]
PHST- 2019/02/20 00:00 [revised]
PHST- 2019/04/09 00:00 [accepted]
PHST- 2019/05/14 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2019/05/14 06:00 [entrez]
AID - S1879-4068(18)30472-7 [pii]
AID - 10.1016/j.jgo.2019.04.009 [doi]
PST - ppublish
SO  - J Geriatr Oncol. 2020 Apr;11(3):402-409. doi: 10.1016/j.jgo.2019.04.009. Epub 
      2019 May 10.