PMID- 31080228
OWN - NLM
STAT- MEDLINE
DCOM- 20200730
LR  - 20200730
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 83
IP  - 7
DP  - 2019 Jun 25
TI  - Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by 
      Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male 
      Triathletes With Normal Ejection Fraction.
PG  - 1553-1562
LID - 10.1253/circj.CJ-18-1388 [doi]
AB  - BACKGROUND: To analyze the effect of myocardial fibrosis on left ventricular (LV) 
      function evaluated by feature-tracking strain analysis by cine cardiac magnetic 
      resonance (CMR) in competitive male triathletes with normal ejection fraction 
      (EF).Methods and Results:78 asymptomatic male triathletes with >10 weekly 
      training hours (43+/-11 years) and 28 male age-matched controls were studied by 
      late gadolinium enhancement (LGE) and cine CMR. Global and segmental radial, 
      longitudinal and circumferential strains were analyzed using feature-tracking 
      cine CMR. Focal non-ischemic LGE was observed in 15 of 78 triathletes (19%, LGE+) 
      with predominance in the basal inferolateral segments. LVEF was normal in LGE+ 
      (62+/-6%) and LGE- triathletes (62+/-5%, P=0.958). In contrast, global radial strain 
      was lower in LGE+ triathletes at 40+/-7% compared with LGE- triathletes (45+/-7%, 
      P<0.05). Reduced segmental radial strain occurred either in LGE+ segments or in 
      directly adjacent segments. Strain analysis revealed regional differences in 
      controls, with the highest radial and longitudinal strain in the inferolateral 
      segments, which were typically affected by fibrosis in LGE+ triathletes. 
      CONCLUSIONS: Reduced global and regional radial strain suggests a negative effect 
      of myocardial fibrosis on LV function in LGE+ triathletes with normal EF. The 
      observed regional differences in controls with the highest radial and 
      longitudinal strain in the inferolateral segments may explain the typical 
      occurrence of fibrosis in this myocardial region in triathletes.
FAU - Tahir, Enver
AU  - Tahir E
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg Eppendorf.
FAU - Starekova, Jitka
AU  - Starekova J
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg Eppendorf.
FAU - Muellerleile, Kai
AU  - Muellerleile K
AD  - Department of General and Interventional Cardiology, University Heart Center.
FAU - Freiwald, Eric
AU  - Freiwald E
AD  - Institute for Medical Biometry and Epidemiology, University Hospital Hamburg 
      Eppendorf.
FAU - von Stritzky, Alexandra
AU  - von Stritzky A
AD  - Department of General and Interventional Cardiology, University Heart Center.
FAU - Munch, Julia
AU  - Munch J
AD  - Department of General and Interventional Cardiology, University Heart Center.
FAU - Avanesov, Maxim
AU  - Avanesov M
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg Eppendorf.
FAU - Weinrich, Julius Matthias
AU  - Weinrich JM
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg Eppendorf.
FAU - Stehning, Christian
AU  - Stehning C
AD  - Philips Clinical Science.
FAU - Cavus, Ersin
AU  - Cavus E
AD  - Department of General and Interventional Cardiology, University Heart Center.
FAU - Bohnen, Sebastian
AU  - Bohnen S
AD  - Department of General and Interventional Cardiology, University Heart Center.
FAU - Radunski, Ulf K
AU  - Radunski UK
AD  - Department of General and Interventional Cardiology, University Heart Center.
FAU - Blankenberg, Stefan
AU  - Blankenberg S
AD  - Department of General and Interventional Cardiology, University Heart Center.
FAU - Adam, Gerhard
AU  - Adam G
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg Eppendorf.
FAU - Simon, Perikles
AU  - Simon P
AD  - Department of Sports Medicine, Johannes Gutenberg University Mainz.
FAU - Pressler, Axel
AU  - Pressler A
AD  - Department of Prevention, Rehabilitation and Sports Medicine, Klinikum rechts der 
      Isar, Technische Universitat Munchen.
AD  - Center of Sports and Preventive Cardiology.
FAU - Patten, Monica
AU  - Patten M
AD  - Department of General and Interventional Cardiology, University Heart Center.
FAU - Lund, Gunnar K
AU  - Lund GK
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Hospital Hamburg Eppendorf.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190511
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Athletes
MH  - *Cardiomyopathies/diagnostic imaging/physiopathology
MH  - Fibrosis
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - *Myocardium
MH  - *Stroke Volume
MH  - *Ventricular Function, Left
OTO - NOTNLM
OT  - Athletes
OT  - Cardiac magnetic resonance imaging
OT  - Contrast media
OT  - Fibrosis
OT  - Myocardium
EDAT- 2019/05/14 06:00
MHDA- 2020/07/31 06:00
CRDT- 2019/05/14 06:00
PHST- 2019/05/14 06:00 [pubmed]
PHST- 2020/07/31 06:00 [medline]
PHST- 2019/05/14 06:00 [entrez]
AID - 10.1253/circj.CJ-18-1388 [doi]
PST - ppublish
SO  - Circ J. 2019 Jun 25;83(7):1553-1562. doi: 10.1253/circj.CJ-18-1388. Epub 2019 May 
      11.