PMID- 31080264
OWN - NLM
STAT- MEDLINE
DCOM- 20200701
LR  - 20220531
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 60
IP  - 5
DP  - 2019 May
TI  - Intraoperative acridine orange photodynamic therapy and cribriform electron-beam 
      irradiation for canine intranasal carcinomas: 14 cases.
PG  - 509-513
AB  - Canine intranasal carcinomas are almost always malignant. Surgery alone often 
      results in rapid tumor regrowth. Radiotherapy is the treatment of choice for dogs 
      with intranasal tumors. Here, we retrospectively assessed treatment of intranasal 
      carcinoma by marginal tumor resection followed by intraoperative acridine orange 
      (AO) photodynamic therapy (PDT) and cribriform plate electron-beam intraoperative 
      radiotherapy (IORT). Fourteen canine cases were assessed, 12 of which had stage I 
      tumors, one with stage III, and one with stage IV. Recurrence was detected in 8, 
      with a median recurrence from the time of treatment of 6 months (range: 3 to 16 
      months). The median progression-free survival time and overall survival time 
      after treatment were 13 and 22 months, respectively. Adverse events were mild. 
      Marginal tumor resection followed by intraoperative AO-PDT and cribriform plate 
      electron-beam IORT may increase the tumor control time in dogs with marginally 
      resectable intranasal malignant tumors beyond that incurred by surgery alone.
FAU - Maruo, Takuya
AU  - Maruo T
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
FAU - Fukuyama, Yasuhiro
AU  - Fukuyama Y
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
FAU - Nagata, Koichi
AU  - Nagata K
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
FAU - Yoshioka, Chie
AU  - Yoshioka C
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
FAU - Nishiyama, Yuta
AU  - Nishiyama Y
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
FAU - Kawarai, Shinpei
AU  - Kawarai S
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
FAU - Kayanuma, Hideki
AU  - Kayanuma H
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
FAU - Orito, Kensuke
AU  - Orito K
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
FAU - Nakayama, Tomohiro
AU  - Nakayama T
AD  - Veterinary Teaching Hospital (Maruo, Fukuyama, Yoshioka, Nishiyama, Kawarai), 
      Laboratory of Veterinary Radiology (Kayanuma), Laboratory of Veterinary 
      Physiology II (Orito), Department of Veterinary Medicine, Azabu University, 
      1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan; College of 
      Veterinary Medicine, The University of Georgia, 501 D.W. Brooks Drive, Athens, 
      Georgia 30602, USA (Nagata); Laboratory of Veterinary Radiology, Department of 
      Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 
      Kameino, Fujisawa, Kanagawa 252-0880, Japan (Nakayama).
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - *Acridine Orange
MH  - Animals
MH  - Combined Modality Therapy/veterinary
MH  - *Dog Diseases
MH  - Dogs
MH  - Electrons
MH  - Intraoperative Care/veterinary
MH  - Neoplasm Recurrence, Local/veterinary
MH  - Photochemotherapy/*veterinary
MH  - Retrospective Studies
PMC - PMC6463768
EDAT- 2019/05/14 06:00
MHDA- 2020/07/02 06:00
PMCR- 2019/11/01
CRDT- 2019/05/14 06:00
PHST- 2019/05/14 06:00 [entrez]
PHST- 2019/05/14 06:00 [pubmed]
PHST- 2020/07/02 06:00 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - cvj_05_509 [pii]
PST - ppublish
SO  - Can Vet J. 2019 May;60(5):509-513.