PMID- 31081573
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Linking)
VI  - 21
IP  - 7
DP  - 2019 Nov
TI  - The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) 
      project: Understanding older-age bipolar disorder by combining multiple datasets.
PG  - 642-649
LID - 10.1111/bdi.12795 [doi]
AB  - OBJECTIVE: There is a dearth of research about the aging process among 
      individuals with bipolar disorder (BD). One potential strategy to overcome the 
      challenge of interpreting findings from existing limited older-age bipolar 
      disorder (OABD) research studies is to pool or integrate data, taking advantage 
      of potential overlap or similarities in assessment methods and harmonizing or 
      cross-walking measurements where different measurement tools are used to evaluate 
      overlapping construct domains. This report describes the methods and initial 
      start-up activities of a first-ever initiative to create an integrated 
      OABD-focused database, the Global Aging & Geriatric Experiments in Bipolar 
      Disorder Database (GAGE-BD) project. METHODS: Building on preliminary work 
      conducted by members of the International Society for Bipolar Disorders OABD 
      taskforce, the GAGE-BD project will be operationalized in four stages intended to 
      ready the dataset for hypothesis-driven analyses, establish a consortium of 
      investigators to guide exploration, and set the stage for prospective 
      investigation using a common dataset that will facilitate a high degree of 
      generalizability. RESULTS: Initial efforts in GAGE-BD have brought together 14 
      international investigators representing a broad geographic distribution and data 
      on over 1,000 OABD. Start-up efforts include communication and guidance on 
      meeting regulatory requirements, establishing a Steering Committee to guide an 
      incremental analysis strategy, and learning from existing multisite data 
      collaborations and other support resources. DISCUSSION: The GAGE-BD project aims 
      to advance understanding of associations between age, BD symptoms, medical 
      burden, cognition and functioning across the life span and set the stage for 
      future prospective research that can advance the understanding of OABD.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Sajatovic, Martha
AU  - Sajatovic M
AUID- ORCID: 0000-0002-3073-668X
AD  - Case Western Reserve University School of Medicine, University Hospitals Case 
      Medical Center, Cleveland, Ohio.
FAU - Eyler, Lisa T
AU  - Eyler LT
AD  - Department of Psychiatry, University of California San Diego, San Diego, 
      California.
AD  - Desert-Pacific Mental Illness Research Education and Clinical Center, VA San 
      Diego Healthcare System, San Diego, California.
FAU - Rej, Soham
AU  - Rej S
AUID- ORCID: 0000-0002-3908-9124
AD  - Lady Davis Insitute, McGill University, Montreal, Canada.
FAU - Almeida, Osvaldo P
AU  - Almeida OP
AUID- ORCID: 0000-0002-8689-6199
AD  - Medical School, University of Western Australia, Perth, Australia.
FAU - Blumberg, Hilary P
AU  - Blumberg HP
AD  - Yale School of Medicine, New Haven, Connecticut.
FAU - Forester, Brent P
AU  - Forester BP
AD  - McLean Hospital, Belmont, Massachusetts.
AD  - Harvard Medical School, Boston, MA.
FAU - Forlenza, Orestes V
AU  - Forlenza OV
AUID- ORCID: 0000-0002-6962-5899
AD  - Laboratory of Neuroscience (LIM-27), Departamento e Instituto de Psiquiatria, 
      Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de Sao 
      Paulo, Sao Paulo, SP, Brazil.
FAU - Gildengers, Ariel
AU  - Gildengers A
AUID- ORCID: 0000-0001-9216-988X
AD  - Ariel Gildengers, University of Pittsburgh School of Medicine, Pittsburgh, 
      Pennsylvania.
FAU - Mulsant, Benoit H
AU  - Mulsant BH
AUID- ORCID: 0000-0002-0303-6450
AD  - Department of Psychiatry, Center for Addiction & Mental Health, University of 
      Toronto, Toronto, Canada.
FAU - Strejilevich, Sergio
AU  - Strejilevich S
AUID- ORCID: 0000-0001-8410-7187
AD  - AREA, Assistance and Research in Affective Disorders, Buenos Aires, Argentina.
FAU - Tsai, Shangying
AU  - Tsai S
AUID- ORCID: 0000-0001-5662-0055
AD  - Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Vieta, Eduard
AU  - Vieta E
AUID- ORCID: 0000-0002-0548-0053
AD  - Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
FAU - Young, Robert C
AU  - Young RC
AD  - Weill Cornell Medicine and New York-Presbyterian Hospital, White Plains, New 
      York.
FAU - Dols, Annemiek
AU  - Dols A
AUID- ORCID: 0000-0003-1964-0318
AD  - GGZ inGeest, Amsterdam UMC, location VU Medical Center, Amsterdam Neuroscience, 
      Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190530
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
SB  - IM
MH  - Aged
MH  - Aging/*psychology
MH  - Bipolar Disorder/physiopathology/*psychology
MH  - Cognition
MH  - Databases, Factual
MH  - *Datasets as Topic
MH  - Humans
MH  - International Cooperation
MH  - Middle Aged
OTO - NOTNLM
OT  - bipolar disorder
OT  - elderly
OT  - geriatric
OT  - manic-depressive disorder
EDAT- 2019/05/14 06:00
MHDA- 2020/02/25 06:00
CRDT- 2019/05/14 06:00
PHST- 2019/05/14 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2019/05/14 06:00 [entrez]
AID - 10.1111/bdi.12795 [doi]
PST - ppublish
SO  - Bipolar Disord. 2019 Nov;21(7):642-649. doi: 10.1111/bdi.12795. Epub 2019 May 30.