PMID- 31081725
OWN - NLM
STAT- MEDLINE
DCOM- 20190705
LR  - 20190705
IS  - 1607-8454 (Electronic)
IS  - 1024-5332 (Linking)
VI  - 24
IP  - 1
DP  - 2019 Dec
TI  - Upfront autologous hematopoietic stem cell transplantation in patients with 
      high-risk stage III to IV Hodgkin lymphoma: a multicenter retrospective cohort 
      study.
PG  - 225-231
LID - 10.1080/16078454.2018.1555024 [doi]
AB  - BACKGROUND/OBJECTIVE: Nearly 30% of patients with advanced-stage Hodgkin lymphoma 
      (HL) are not cured. We should better control tumors with initial treatment for 
      patients with advanced stage HL whose interim positron emission 
      tomography/computed tomography (PET/CT) was positive. The objective of our study 
      was to confirm the superiority of autologous hematopoietic stem cell 
      transplantation (ASCT) therapy in these patients. METHODS: Eighty-nine HL 
      patients with stage III-IV, international prognostic score (IPS) >/=3 and Deauville 
      more than 3 degrees  at the interim PET/CT were analyzed. Forty five patients received 
      ASCT. The other 44 patients received two cycles DHAP chemotherapy. RESULTS: The 
      3-year overall survival (OS) of patients who received ASCT was 91.1%, and for the 
      patients who received chemotherapy, it was 72.7% (P = 0.025). The 3-year 
      progression free survival (PFS) of patients in the ASCT group was 88.9%, but for 
      patients in the chemotherapy group, it was only 70.5%(P = 0.017). No patient died 
      of toxicity from ASCT. Additionally, there was no difference in the rates of 
      secondary malignancies between the ASCT and chemotherapy groups. Extranodal and 
      bone marrow involvement were poor prognostic factors, while ASCT was a good 
      prognostic factor. CONCLUSION: The use of ASCT as a first-line consolidation 
      treatment could improve outcome of patients with advanced-stage high risk HL 
      whose interim PET/CT was positive.
FAU - Gao, Li
AU  - Gao L
AD  - a Department of Hematology, Xinqiao Hospital , Army Military Medical University , 
      Chongqing , People's Republic of China.
FAU - Xiang, Xixi
AU  - Xiang X
AD  - a Department of Hematology, Xinqiao Hospital , Army Military Medical University , 
      Chongqing , People's Republic of China.
FAU - Zhang, Cheng
AU  - Zhang C
AD  - a Department of Hematology, Xinqiao Hospital , Army Military Medical University , 
      Chongqing , People's Republic of China.
FAU - Gao, Lei
AU  - Gao L
AD  - a Department of Hematology, Xinqiao Hospital , Army Military Medical University , 
      Chongqing , People's Republic of China.
FAU - Yang, Tonghua
AU  - Yang T
AD  - b Department of Hematology , Yunnan Provincial People's Hospital , Yunnan , 
      People's Republic of China.
FAU - Wang, Sanbin
AU  - Wang S
AD  - c Department of Hematology , General Hospital of Kunming Military Region of PLA , 
      Yunnan , People's Republic of China.
FAU - Li, Bin
AU  - Li B
AD  - d Department of Hematology , Yunnan Provincial Second People's Hospital , Yunnan 
      , People's Republic of China.
FAU - Lou, Shifeng
AU  - Lou S
AD  - e Department of Hematology, The Second Affiliated Hospital , Chongqing Medical 
      University , Chongqing , People's Republic of China.
FAU - Yi Su
AU  - Yi Su
AD  - f Department of Hematology , General Hospital of Chengdu Military Region of PLA , 
      Sichuan , People's Republic of China.
FAU - Liu, Yao
AU  - Liu Y
AD  - a Department of Hematology, Xinqiao Hospital , Army Military Medical University , 
      Chongqing , People's Republic of China.
FAU - Zhang, Xi
AU  - Zhang X
AD  - a Department of Hematology, Xinqiao Hospital , Army Military Medical University , 
      Chongqing , People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
SB  - IM
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Hodgkin Disease/pathology/*therapy
MH  - Humans
MH  - Male
MH  - Neoplasm Staging
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Transplantation Conditioning/*methods
MH  - Transplantation, Autologous/*methods
OTO - NOTNLM
OT  - Hodgkin lymphoma
OT  - autologous hematopoietic stem cell transplantation
EDAT- 2019/05/14 06:00
MHDA- 2019/07/06 06:00
CRDT- 2019/05/14 06:00
PHST- 2019/05/14 06:00 [entrez]
PHST- 2019/05/14 06:00 [pubmed]
PHST- 2019/07/06 06:00 [medline]
AID - 10.1080/16078454.2018.1555024 [doi]
PST - ppublish
SO  - Hematology. 2019 Dec;24(1):225-231. doi: 10.1080/16078454.2018.1555024.