PMID- 31082734
OWN - NLM
STAT- MEDLINE
DCOM- 20190603
LR  - 20190603
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 195
DP  - 2019 Jun
TI  - Fabrication of resveratrol coated gold nanoparticles and investigation of their 
      effect on diabetic retinopathy in streptozotocin induced diabetic rats.
PG  - 51-57
LID - S1011-1344(19)30423-3 [pii]
LID - 10.1016/j.jphotobiol.2019.04.012 [doi]
AB  - This study includes the fabrication of gold nanoparticles (AuNPs) with the help 
      of a plant polyphenol called Resveratrol through an ecofriendly synthetic process 
      without any use of harmful reductants. In the fabrication of AuNPs, Resveratrol 
      acts as both stabilizing and reducing agent. The prepared AuNPs is tested on 
      streptozotocin (STZ) induced diabetic rats for their amelioration consequence. 
      The images of TEM displayed the development of spherical nanoparticles (NPs) with 
      a median of 20 nm particle size. The STZ injected diabetic rats were 
      administrated orally with calcium dobesilate (CD; 500 mg/kg/day) or AuNPs (200, 
      300 mg/kg/day) for a period of 3 months. The characteristics displayed by AuNPs 
      were found to be similar with CD in decreasing permeability of blood-retinal 
      barrier in STZ injected diabetic rats. The retinal vessels in the AuNPs 
      administrated diabetic rats were observed to be decreased through the retinal 
      histopathological examination. In the AuNPs administrated diabetic rats, the 
      retinal expression of renal Pigment Epithelium-Derived Factor (PEDF) was observed 
      to be increased and the Vascular Endothelial Growth Factor (VEGF-1), which was 
      increased in diabetic rats was declined on treating with AuNPs. On treating the 
      STZ injected diabetic rats with AuNPs, all the retinal mRNA expressions of 
      VEGF-1, Tumor Necrosis Factor (TNFalpha), Monocyte Chemotactic Proteins-1 (MCP-1), 
      Intercellular Adhesion Molecule-1 (ICAM-1), and Interleukin (IL)-6, IL-1beta were 
      observed to be reduced. Furthermore, AuNPs can reduce phosphorylation of Nuclear 
      Factor Kappa B (NF-kappaB) p65 and Extracellular signal Regulated Kinase (ERK) 1/2 
      along with a growth in nuclear translocation of pNF-kappaB p65 produced by STZ. To 
      conclude, the protective effect of AuNPs on STZ injected diabetic rats could help 
      in redeveloping the balance among the inhibitors and stimulators of angiogenesis. 
      Furthermore, on treating with AuNPs results in inhibiting the signaling pathway 
      of ERK1/2 as well as with amelioration of retinal inflammation through trans 
      repression of NF-kappaB.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Dong, Yi
AU  - Dong Y
AD  - Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, 
      Henan Province, Eye Hospital, Zhengzhou 450052, China.
FAU - Wan, Guangming
AU  - Wan G
AD  - Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, 
      Henan Province, Eye Hospital, Zhengzhou 450052, China. Electronic address: 
      wanguangming@yahoo.com.
FAU - Yan, Panshi
AU  - Yan P
AD  - Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, 
      Henan Province, Eye Hospital, Zhengzhou 450052, China.
FAU - Qian, Cheng
AU  - Qian C
AD  - Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, 
      Henan Province, Eye Hospital, Zhengzhou 450052, China.
FAU - Li, Fuzhen
AU  - Li F
AD  - Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, 
      Henan Province, Eye Hospital, Zhengzhou 450052, China.
FAU - Peng, Guanghua
AU  - Peng G
AD  - School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 45000, China.
LA  - eng
PT  - Journal Article
DEP - 20190502
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Blood Glucose)
RN  - 0 (Eye Proteins)
RN  - 0 (ICAM1 protein, rat)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Serpins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (pigment epithelium-derived factor)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 5W494URQ81 (Streptozocin)
RN  - 7440-57-5 (Gold)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Experimental/chemically induced/complications/pathology
MH  - Diabetic Retinopathy/*drug therapy/etiology
MH  - Eye Proteins/metabolism
MH  - Gold/*chemistry
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Metal Nanoparticles/*chemistry
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - NF-kappa B/metabolism
MH  - Nerve Growth Factors/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Resveratrol/*chemistry/therapeutic use
MH  - Retina/metabolism/pathology
MH  - Serpins/metabolism
MH  - Signal Transduction
MH  - Streptozocin/toxicity
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2019/05/15 06:00
MHDA- 2019/06/04 06:00
CRDT- 2019/05/15 06:00
PHST- 2019/04/03 00:00 [received]
PHST- 2019/04/25 00:00 [revised]
PHST- 2019/04/30 00:00 [accepted]
PHST- 2019/05/15 06:00 [pubmed]
PHST- 2019/06/04 06:00 [medline]
PHST- 2019/05/15 06:00 [entrez]
AID - S1011-1344(19)30423-3 [pii]
AID - 10.1016/j.jphotobiol.2019.04.012 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2019 Jun;195:51-57. doi: 
      10.1016/j.jphotobiol.2019.04.012. Epub 2019 May 2.