PMID- 31082797
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20190805
IS  - 2212-1102 (Electronic)
IS  - 2212-1099 (Linking)
VI  - 18
DP  - 2019 May
TI  - Healthcare Resource Utilization and the Cost of Care for Mucopolysaccharidosis I 
      Patients in Iran.
PG  - 165-169
LID - S2212-1099(19)30049-4 [pii]
LID - 10.1016/j.vhri.2019.01.009 [doi]
AB  - BACKGROUND: Mucopolysaccharidosis I (MPS-I) is one of the most common types of 
      MPS and lysosomal storage diseases, which impose considerable amount of economic 
      burden on society. OBJECTIVES: The aim of this study was to examine the cost 
      drivers in the treatment of MPS-I patients in Iran. METHODS: This is a 
      cost-analysis study. The prevalence approach was used to evaluate costs from the 
      healthcare payer's perspective. The number of patients found to have 
      alpha-L-iduronidase deficiency was identified using the national registry database of 
      the Ministry of Health (MOH). The direct medical costs of the patients were 
      evaluated. Prescriptions; medical interventions; inpatient, outpatient, and 
      diagnostic services, and also their costs were extracted from the patient's 
      profiles in Iran Food and Drug Administration (IFDA). The prices of the medical 
      services were taken out from Iranian medical tariff book 2014-15. Data extraction 
      was performed from January 2017 to March 2018. RESULTS: Sixty-six patients were 
      registered as MPS-I in MOH databases. The average annual healthcare cost for 
      every patient was $87 971.99, 96.9% of which was allocated to medication therapy. 
      Therapeutic and diagnostic services costs (2.4% and 0.7% correspondingly) were 
      ranked second and third, respectively, but with huge differences in medication 
      cost. CONCLUSIONS: The average annual cost of treatment for MPS-I patients is as 
      high as 16.2 times the GDP per capita in Iran. The highest share of the cost 
      belongs to medication. Selecting appropriate strategies for reducing the birth of 
      a child with MPS could support allocative efficiency of the limited resources 
      effectively.
CI  - Copyright (c) 2019 ISPOR--The professional society for health economics and 
      outcomes research. Published by Elsevier Inc. All rights reserved.
FAU - Davari, Majid
AU  - Davari M
AD  - Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of 
      Pharmacy, Tehran University of Medical Science, Tehran, Iran.
FAU - Nabizadeh, Azita
AU  - Nabizadeh A
AD  - Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of 
      Pharmacy, Tehran University of Medical Science, Tehran, Iran. Electronic address: 
      a-nabizadeh@razi.tums.ac.ir.
FAU - Kadivar, Maliheh
AU  - Kadivar M
AD  - Division of Neonatology, Department of Pediatrics, Children's Medical Center, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Abdollahi Asl, Akbar
AU  - Abdollahi Asl A
AD  - Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of 
      Pharmacy, Tehran University of Medical Science, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190510
PL  - United States
TA  - Value Health Reg Issues
JT  - Value in health regional issues
JID - 101592642
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Health Care Costs/statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Iran
MH  - Male
MH  - Mucopolysaccharidosis I/*economics
MH  - Patient Acceptance of Health Care/*statistics & numerical data
OTO - NOTNLM
OT  - Iran
OT  - MPS-I
OT  - healthcare
OT  - laronidase
OT  - resource utilization
EDAT- 2019/05/15 06:00
MHDA- 2019/08/06 06:00
CRDT- 2019/05/15 06:00
PHST- 2018/04/10 00:00 [received]
PHST- 2018/12/09 00:00 [revised]
PHST- 2019/01/31 00:00 [accepted]
PHST- 2019/05/15 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
PHST- 2019/05/15 06:00 [entrez]
AID - S2212-1099(19)30049-4 [pii]
AID - 10.1016/j.vhri.2019.01.009 [doi]
PST - ppublish
SO  - Value Health Reg Issues. 2019 May;18:165-169. doi: 10.1016/j.vhri.2019.01.009. 
      Epub 2019 May 10.