PMID- 31082858
OWN - NLM
STAT- MEDLINE
DCOM- 20200901
LR  - 20200901
IS  - 2155-384X (Electronic)
IS  - 2155-384X (Linking)
VI  - 10
IP  - 5
DP  - 2019 May 22
TI  - Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in 
      the Diet Associated With Progression to Celiac Disease.
PG  - 1-10
LID - 10.14309/ctg.0000000000000044 [doi]
LID - e00044
AB  - OBJECTIVES: Celiac disease (CD) is a chronic enteropathy characterized by an 
      autoimmune reaction in the small intestine of genetically susceptible 
      individuals. The underlying causes of autoimmune reaction and its effect on host 
      metabolism remain largely unknown. Herein, we apply lipidomics to elucidate the 
      early events preceding clinical CD in a cohort of Finnish children, followed up 
      in the Type 1 Diabetes Prediction and Prevention study. METHODS: Mass 
      spectrometry-based lipidomics profiling was applied to a longitudinal/prospective 
      series of 233 plasma samples obtained from CD progressors (n = 23) and healthy 
      controls (n = 23), matched for human leukocyte antigen (HLA) risk, sex, and age. 
      The children were followed from birth until diagnosis of clinical CD and 
      subsequent introduction of a gluten-free diet. RESULTS: Twenty-three children 
      progressed to CD at a mean age of 4.8 years. They showed increased amounts of 
      triacylglycerols (TGs) of low carbon number and double bond count and a decreased 
      level of phosphatidylcholines by age 3 months as compared to controls. These 
      differences were exacerbated with age but were not observed at birth (cord 
      blood). No significant differences were observed in the essential TGs. 
      DISCUSSION: Our preliminary findings suggest that abnormal lipid metabolism 
      associates with the development of clinical CD and occurs already before the 
      first introduction of gluten to the diet. Moreover, our data suggest that the 
      specific TGs found elevated in CD progressors may be due to a host response to 
      compromised intake of essential lipids in the small intestine, requiring de novo 
      lipogenesis.
FAU - Sen, Partho
AU  - Sen P
AD  - Turku Centre for Biotechnology, University of Turku and Abo Akademi University, 
      Turku, Finland.
FAU - Carlsson, Cecilia
AU  - Carlsson C
AD  - Department of Chemistry, Orebro University, Orebro, Sweden.
FAU - Virtanen, Suvi M
AU  - Virtanen SM
AD  - Public Health Promotion Unit, National Institute for Health and Welfare, 
      Helsinki, Helsinki, Finland.
AD  - Faculty of Social Sciences/Health, University of Tampere, Tampere, Finland.
AD  - Center for Child Health Research, University of Tampere and Tampere University 
      Hospital, Tampere, Finland.
AD  - Science Centre, Tampere University Hospital, Tampere, Finland.
FAU - Simell, Satu
AU  - Simell S
AD  - Department of Paediatrics and Adolescent Medicine, Turku University Hospital, 
      Turku, Finland.
FAU - Hyoty, Heikki
AU  - Hyoty H
AD  - Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
AD  - Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.
FAU - Ilonen, Jorma
AU  - Ilonen J
AD  - Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, 
      Finland.
AD  - Clinical Microbiology, Turku University Hospital, Turku, Finland.
FAU - Toppari, Jorma
AU  - Toppari J
AD  - Department of Paediatrics and Adolescent Medicine, Turku University Hospital, 
      Turku, Finland.
AD  - Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, 
      University of Turku, Turku, Finland.
FAU - Veijola, Riitta
AU  - Veijola R
AD  - Department of Paediatrics, PEDEGO Research Unit, Medical Research Centre, 
      University of Oulu, Oulu, Finland.
AD  - Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Hyotylainen, Tuulia
AU  - Hyotylainen T
AD  - Department of Chemistry, Orebro University, Orebro, Sweden.
FAU - Knip, Mikael
AU  - Knip M
AD  - Children's Hospital, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
AD  - Tampere Centre for Child Health Research, Tampere University Hospital, Tampere, 
      Finland.
FAU - Oresic, Matej
AU  - Oresic M
AD  - Turku Centre for Biotechnology, University of Turku and Abo Akademi University, 
      Turku, Finland.
AD  - School of Medical Sciences, Orebro University, Orebro, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Transl Gastroenterol
JT  - Clinical and translational gastroenterology
JID - 101532142
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Triglycerides)
RN  - 8002-80-0 (Glutens)
SB  - IM
MH  - Autoimmunity
MH  - Biopsy
MH  - Celiac Disease/blood/*diagnosis/diet therapy/immunology
MH  - Child, Preschool
MH  - Diet, Gluten-Free
MH  - Disease Progression
MH  - Endoscopy, Gastrointestinal
MH  - Finland
MH  - Glutens/administration & dosage/*immunology
MH  - HLA-DQ Antigens/blood/immunology
MH  - Humans
MH  - Infant
MH  - Intestinal Absorption/immunology
MH  - Intestinal Mucosa/diagnostic imaging/immunology/*metabolism/pathology
MH  - Intestine, Small/diagnostic imaging/immunology/*metabolism/pathology
MH  - Lipid Metabolism/immunology
MH  - Lipidomics
MH  - Longitudinal Studies
MH  - Prospective Studies
MH  - Triglycerides/*blood/metabolism
PMC - PMC6602763
EDAT- 2019/05/15 06:00
MHDA- 2020/09/02 06:00
PMCR- 2019/05/10
CRDT- 2019/05/15 06:00
PHST- 2019/05/15 06:00 [pubmed]
PHST- 2020/09/02 06:00 [medline]
PHST- 2019/05/15 06:00 [entrez]
PHST- 2019/05/10 00:00 [pmc-release]
AID - CTG-19-0100 [pii]
AID - 10.14309/ctg.0000000000000044 [doi]
PST - ppublish
SO  - Clin Transl Gastroenterol. 2019 May 22;10(5):1-10. doi: 
      10.14309/ctg.0000000000000044.