PMID- 31083216
OWN - NLM
STAT- MEDLINE
DCOM- 20190530
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 19
DP  - 2019 May
TI  - Oseltamivir induced Stevens-Johnson syndrome/toxic epidermal necrolysis-case 
      report.
PG  - e15553
LID - 10.1097/MD.0000000000015553 [doi]
LID - e15553
AB  - RATIONALE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) 
      are 2 rare but life-threatening diseases characterized by detachment of 
      epidermis, bullous skin lesions, and mucous membrane erosions. Drugs are highly 
      suspected to be the causative agents. We report a case of SJS/TEN induced by 
      oseltamivir, which is a very rare event. PATIENT CONCERNS: A 9-year-old girl with 
      upper respiratory tract infections presented with generalized maculopapular rash 
      the second day after taking oseltamivir. DIAGNOSIS: The diagnosis of SJS/TEN was 
      made based on cytotoxic skin lesions and mucous membrane involvement. 
      INTERVENTIONS: After discontinuing of the drug and combination therapy of 
      corticosteroid and human immunoglobulin initiation, the lesions were improved. 
      Human leukocyte antigen (HLA) gene sequencing was done. OUTCOMES: The girl was 
      followed-up for 1 year. The skin and mucous membranes symptoms were relieved. 
      LESSONS: We report this case to attract attention to the rare but serious side 
      effect of this antiviral drug.
FAU - Zuo, Wei
AU  - Zuo W
AD  - Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Beijing.
AD  - Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), 
      Ministry of Education", Yantai University, Yantai, China.
FAU - Wen, Li-Ping
AU  - Wen LP
AD  - Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Beijing.
FAU - Li, Jun
AU  - Li J
AD  - Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Beijing.
FAU - Mei, Dan
AU  - Mei D
AD  - Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Beijing.
FAU - Fu, Qiang
AU  - Fu Q
AD  - Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Beijing.
FAU - Zhang, Bo
AU  - Zhang B
AD  - Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Beijing.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antiviral Agents)
RN  - 0 (HLA-A*02:06 antigen)
RN  - 0 (HLA-A2 Antigen)
RN  - 20O93L6F9H (Oseltamivir)
SB  - IM
MH  - Antiviral Agents/*adverse effects/therapeutic use
MH  - Child
MH  - Female
MH  - HLA-A2 Antigen/genetics
MH  - Humans
MH  - Oseltamivir/*adverse effects/therapeutic use
MH  - Respiratory Tract Infections/drug therapy
MH  - Stevens-Johnson Syndrome/diagnosis/*etiology/genetics/therapy
PMC - PMC6531182
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/05/15 06:00
MHDA- 2019/05/31 06:00
PMCR- 2019/05/13
CRDT- 2019/05/15 06:00
PHST- 2019/05/15 06:00 [entrez]
PHST- 2019/05/15 06:00 [pubmed]
PHST- 2019/05/31 06:00 [medline]
PHST- 2019/05/13 00:00 [pmc-release]
AID - 00005792-201905100-00068 [pii]
AID - MD-D-18-07857 [pii]
AID - 10.1097/MD.0000000000015553 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 May;98(19):e15553. doi: 10.1097/MD.0000000000015553.