PMID- 31083564
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20211204
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 9
DP  - 2019 May 11
TI  - The Cross-Talk Between the TNF-alpha and RASSF-Hippo Signalling Pathways.
LID - 10.3390/ijms20092346 [doi]
LID - 2346
AB  - The regulation of cell death through apoptosis is essential to a number of 
      physiological processes. Defective apoptosis regulation is associated with many 
      abnormalities including anomalies in organ development, altered immune response 
      and the development of cancer. Several signalling pathways are known to regulate 
      apoptosis including the Tumour Necrosis Factor-alpha (TNF-alpha) and Hippo signalling 
      pathways. In this paper we review the cross-talk between the TNF-alpha pathway and 
      the Hippo signalling pathway. Several molecules that tightly regulate the Hippo 
      pathway, such as members of the Ras-association domain family member (RASSF) 
      family proteins, interact and modulate some key proteins within the TNF-alpha 
      pathway. Meanwhile, TNF-alpha stimulation also affects the expression and activation 
      of core components of the Hippo pathway. This implies the crucial role of signal 
      integration between these two major pathways in regulating apoptosis.
FAU - Oceandy, Delvac
AU  - Oceandy D
AD  - Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, 
      University of Manchester, Manchester M13 9PT, UK. 
      delvac.oceandy@manchester.ac.uk.
AD  - Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, 
      Surabaya 60132, Indonesia. delvac.oceandy@manchester.ac.uk.
FAU - Amanda, Bella
AU  - Amanda B
AD  - Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, 
      Surabaya 60132, Indonesia. bellaamanda1704@yahoo.com.
FAU - Ashari, Faisal Yusuf
AU  - Ashari FY
AD  - Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, 
      Surabaya 60132, Indonesia. faisalyusufashari@gmail.com.
FAU - Faizah, Zakiyatul
AU  - Faizah Z
AD  - Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, 
      Surabaya 60132, Indonesia. faizbiomed@yahoo.com.
FAU - Azis, M Aminudin
AU  - Azis MA
AD  - Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, 
      Surabaya 60132, Indonesia. azizandro@gmail.com.
FAU - Stafford, Nicholas
AU  - Stafford N
AD  - Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, 
      University of Manchester, Manchester M13 9PT, UK. 
      nicholas.stafford@manchester.ac.uk.
LA  - eng
GR  - PG/17/78/33304/BHF_/British Heart Foundation/United Kingdom
GR  - PG/18/40/33767/BHF_/British Heart Foundation/United Kingdom
GR  - Mandate Research Grant/Universitas Airlangga/
GR  - Collaborative Research Grant/Universitas Airlangga/
PT  - Journal Article
PT  - Review
DEP - 20190511
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Humans
MH  - Models, Biological
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - *Signal Transduction
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - Tumor Suppressor Proteins/*metabolism
PMC - PMC6539482
OTO - NOTNLM
OT  - Hippo pathway
OT  - RASSF
OT  - TNF-alpha
OT  - apoptosis
OT  - signalling pathway
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/15 06:00
MHDA- 2019/09/04 06:00
PMCR- 2019/05/01
CRDT- 2019/05/15 06:00
PHST- 2019/03/27 00:00 [received]
PHST- 2019/05/07 00:00 [revised]
PHST- 2019/05/08 00:00 [accepted]
PHST- 2019/05/15 06:00 [entrez]
PHST- 2019/05/15 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - ijms20092346 [pii]
AID - ijms-20-02346 [pii]
AID - 10.3390/ijms20092346 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 May 11;20(9):2346. doi: 10.3390/ijms20092346.