PMID- 31084659 OWN - NLM STAT- MEDLINE DCOM- 20200907 LR - 20200907 IS - 1469-7661 (Electronic) IS - 1355-6177 (Linking) VI - 25 IP - 7 DP - 2019 Aug TI - The Effects of Radiation and Sex Differences on Adaptive Functioning in Adult Survivors of Pediatric Posterior Fossa Brain Tumors. PG - 729-739 LID - 10.1017/S135561771900033X [doi] AB - OBJECTIVE: Radiation therapy (RT) improves rates of survival of patients with childhood brain tumors but increases deficits in cognition and independent living skills. Previous literature has studied difficulties in basic cognitive processes, but few explore impairment in higher-order skills such as adaptive functioning. Some studies identify females as at risk for cognitive deficits due to RT, but few investigate sex differences in adaptive functioning. It was hypothesized that females would exhibit poorer long-term independent living skills and core cognitive skills relative to males following RT. METHODS: Forty-five adult survivors of posterior fossa childhood brain tumors (24 females) completed the Wechsler Abbreviated Scale of Intelligence (WASI-II), Wechsler Memory Scale, Third Edition (WMS-III) Digit Span Forward (DSF) and Backward (DSB), and Oral Symbol Digit Modalities Test (OSDMT). Informants completed the Scales of Independent Behavior-Revised (SIB-R). RESULTS: DSF and OSDMT were positively correlated with all five SIB-R domains, full-scale IQ (FSIQ) was positively correlated with four SIB-R domains, and DSB was positively correlated with three SIB-R domains. There was an interaction between sex and RT for OSDMT and community living skills with trend level interactions for personal living skills and broad independent living skills, where females without RT had higher scores than females with RT. CONCLUSIONS: Female survivors were more affected by RT than males across the community living skills domain of adaptive functioning as well as processing speed. Processing speed deficits may have a cascading impact on daily living skills. Future studies should investigate how clinical and biological factors may contribute to personalized treatment plans between sexes. (JINS, 2019, 25, 729-739). FAU - Panwala, Tanya F AU - Panwala TF AD - Department of Psychology, Georgia State University, Atlanta, GA, USA. FAU - Fox, Michelle E AU - Fox ME AUID- ORCID: 0000-0003-3833-0964 AD - Department of Psychology, Georgia State University, Atlanta, GA, USA. FAU - Tucker, Tiffany D AU - Tucker TD AD - Department of Psychology, Georgia State University, Atlanta, GA, USA. FAU - King, Tricia Z AU - King TZ AUID- ORCID: 0000-0003-1363-9914 AD - Department of Psychology, Georgia State University, Atlanta, GA, USA. AD - Neuroscience Institute, Georgia State University, Atlanta, GA, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - J Int Neuropsychol Soc JT - Journal of the International Neuropsychological Society : JINS JID - 9503760 SB - IM MH - *Activities of Daily Living MH - Adaptation, Psychological/*physiology MH - Adult MH - *Cancer Survivors MH - Cognitive Dysfunction/*etiology/*physiopathology MH - Female MH - Humans MH - Independent Living MH - Infratentorial Neoplasms/*radiotherapy MH - Male MH - Radiotherapy/*adverse effects MH - Sex Factors OTO - NOTNLM OT - Activities of daily living OT - Cancer survivors OT - Childhood cancer OT - Cognition OT - Females OT - Medulloblastoma EDAT- 2019/05/16 06:00 MHDA- 2020/09/08 06:00 CRDT- 2019/05/16 06:00 PHST- 2019/05/16 06:00 [pubmed] PHST- 2020/09/08 06:00 [medline] PHST- 2019/05/16 06:00 [entrez] AID - S135561771900033X [pii] AID - 10.1017/S135561771900033X [doi] PST - ppublish SO - J Int Neuropsychol Soc. 2019 Aug;25(7):729-739. doi: 10.1017/S135561771900033X.