PMID- 31084755
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20191210
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 115
DP  - 2019 Jun
TI  - Solitary pulmonary nodule: Comparison of quantitative capability for 
      differentiation and management among dynamic CE-perfusion MRI at 3 T system, 
      dynamic CE-perfusion ADCT and FDG-PET/CT.
PG  - 22-30
LID - S0720-048X(19)30113-5 [pii]
LID - 10.1016/j.ejrad.2019.03.018 [doi]
AB  - PURPOSE: To prospectively compare the capability of dynamic first-pass 
      contrast-enhanced (CE) perfusion MR imaging with ultra-short TE and area-detector 
      CT (ADCT), analyzed with the same mathematical methods, and that of FDG-PET/CT 
      for diagnosis and management of solitary pulmonary nodules (SPNs). METHODS AND 
      MATERIALS: Our institutional review board approved this study and written 
      informed consent was obtained from all subjects. A total 57 consecutive patients 
      with 71 nodules prospectively underwent dynamic CE-perfusion ADCT and MR imaging 
      with ultra-short TE, FDG-PET/CT, as well as microbacterial and/or pathological 
      examinations. The nodules were classified into malignant nodules (n = 45) and 
      benign nodules (n = 26). Pulmonary arterial, systemic arterial and total 
      perfusions were determined by means of dual-input maximum slope models on ADCT 
      and MR imaging and maximum values of standard uptake values (SUV(max)) on PET/CT. 
      Receiver operating characteristic (ROC) analysis was performed for each index, 
      and sensitivity, specificity and accuracy were compared by McNemar's test. 
      RESULTS: Areas under the curve (Azs) of total perfusion on ADCT (Az = 0.89) and 
      MR imaging (Az = 0.88) were significantly larger than those of systemic arterial 
      perfusion and MR imaging (p<0.05). Accuracy of total perfusion on ADCT (87.3% 
      [62/71]) and MR imaging (87.3% [62/71]) was significantly higher than that of 
      systemic arterial perfusion for both methods (77.5% [55/71] p = 0.02) and 
      SUV(max) (78.9% [56/71], p = 0.03). CONCLUSION: Dynamic CE-perfusion MR imaging 
      with ultra-short TE and ADCT and have similar potential capabilities, and are 
      superior to FDG-PET/CT in this setting.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Ohno, Yoshiharu
AU  - Ohno Y
AD  - Division of Functional and Diagnostic Imaging Research, Department of Radiology, 
      Kobe University Graduate School of Medicine, Kobe, Japan; Advanced Biomedical 
      Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, 
      Japan; Department of Radiology, Fujita Health University School of Medicine. 
      Electronic address: yosirad@kobe-u.ac.jp.
FAU - Fujisawa, Yasuko
AU  - Fujisawa Y
AD  - Canon Medical Systems Corporation, Otawara, Japan.
FAU - Yui, Masao
AU  - Yui M
AD  - Canon Medical Systems Corporation, Otawara, Japan.
FAU - Takenaka, Daisuke
AU  - Takenaka D
AD  - Department of Radiology, Hyogo Cancer Center, Akashi, Japan.
FAU - Koyama, Hisanobu
AU  - Koyama H
AD  - Department of Radiology, Osaka Police Hospital, Osaka, Japan.
FAU - Sugihara, Naoki
AU  - Sugihara N
AD  - Canon Medical Systems Corporation, Otawara, Japan.
FAU - Yoshikawa, Takeshi
AU  - Yoshikawa T
AD  - Division of Functional and Diagnostic Imaging Research, Department of Radiology, 
      Kobe University Graduate School of Medicine, Kobe, Japan; Advanced Biomedical 
      Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20190328
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*diagnosis
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Lung Neoplasms/*diagnosis
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Perfusion Imaging
MH  - Positron Emission Tomography Computed Tomography/methods
MH  - Prospective Studies
MH  - ROC Curve
MH  - Radiopharmaceuticals
MH  - Sensitivity and Specificity
MH  - Solitary Pulmonary Nodule/*diagnosis
MH  - Tomography, Spiral Computed/methods
MH  - Tomography, X-Ray Computed/methods
OTO - NOTNLM
OT  - CT
OT  - Lung
OT  - MRI
OT  - Nodule
OT  - PET/CT
OT  - Perfusion
EDAT- 2019/05/16 06:00
MHDA- 2019/08/06 06:00
CRDT- 2019/05/16 06:00
PHST- 2019/01/03 00:00 [received]
PHST- 2019/02/20 00:00 [revised]
PHST- 2019/03/24 00:00 [accepted]
PHST- 2019/05/16 06:00 [entrez]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
AID - S0720-048X(19)30113-5 [pii]
AID - 10.1016/j.ejrad.2019.03.018 [doi]
PST - ppublish
SO  - Eur J Radiol. 2019 Jun;115:22-30. doi: 10.1016/j.ejrad.2019.03.018. Epub 2019 Mar 
      28.