PMID- 31085007
OWN - NLM
STAT- MEDLINE
DCOM- 20200114
LR  - 20200114
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 215
IP  - 7
DP  - 2019 Jul
TI  - Histopathologic characteristics of advanced-stage ROS1-rearranged non-small cell 
      lung cancers.
PG  - 152441
LID - S0344-0338(19)30329-2 [pii]
LID - 10.1016/j.prp.2019.152441 [doi]
AB  - BACKGROUND: ROS1 rearrangement accounts for 1%-2% of non-small cell lung cancer 
      (NSCLC) with a remarkable response to crizotinib. Although ROS1-rearranged tumors 
      are known to have characteristic histologic features, only a few studies have 
      investigated the histologic features of advanced-stage ROS1-rearranged tumors. 
      METHODS: We analyzed the histopathologic features of ROS1-rearranged tumors in 
      advanced-stage NSCLC patients and assessed the ROS1 immunohistochemistry (IHC) 
      staining patterns of ROS1-rearranged cases. RESULTS: A total of 37 ROS1 
      fluorescence in situ hybridization (FISH)-positive cases and 64 ROS1 
      FISH-negative cases were analyzed, and all tumors were EGFR-, ALK-, and 
      RET-negative. Solid pattern, round nuclei with macronucleoli, solid signet-ring 
      cells, extracellular mucin, and a close relation with adjacent bronchioles were 
      significantly associated with ROS1 rearrangement, and the solid signet-ring cell 
      feature was exclusively identified in ROS1-rearranged tumors. ROS1 IHC showed a 
      97.3% sensitivity when weak to strong protein expression was considered positive. 
      CONCLUSIONS: Our findings highlight distinct histologic features of 
      ROS1-rearranged tumors, including their nuclear features. A thorough 
      understanding of ROS1 rearrangement-related histologic features would be helpful 
      to identify ROS1-rearranged tumors in advanced-stage NSCLC.
CI  - Copyright (c) 2019 Elsevier GmbH. All rights reserved.
FAU - Park, Eunhyang
AU  - Park E
AD  - Department of Pathology and Translational Genomics, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department 
      of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.
FAU - Choi, Yoon-La
AU  - Choi YL
AD  - Department of Pathology and Translational Genomics, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Ahn, Myung-Ju
AU  - Ahn MJ
AD  - Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
FAU - Han, Joungho
AU  - Han J
AD  - Department of Pathology and Translational Genomics, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic 
      address: hanjho@skku.edu.
LA  - eng
PT  - Journal Article
DEP - 20190506
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (ROS1 protein, human)
SB  - IM
MH  - Adenocarcinoma of Lung/genetics/metabolism/*pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/genetics/metabolism/*pathology
MH  - Cell Nucleus/metabolism/pathology
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - Lung/metabolism/*pathology
MH  - Lung Neoplasms/genetics/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Protein-Tyrosine Kinases/genetics/*metabolism
MH  - Proto-Oncogene Proteins/genetics/*metabolism
OTO - NOTNLM
OT  - FISH
OT  - Histology
OT  - Immunohistochemistry
OT  - Lung adenocarcinoma
OT  - Non-small cell lung cancer (NSCLC)
OT  - ROS1
EDAT- 2019/05/16 06:00
MHDA- 2020/01/15 06:00
CRDT- 2019/05/16 06:00
PHST- 2019/03/04 00:00 [received]
PHST- 2019/04/16 00:00 [revised]
PHST- 2019/05/05 00:00 [accepted]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2020/01/15 06:00 [medline]
PHST- 2019/05/16 06:00 [entrez]
AID - S0344-0338(19)30329-2 [pii]
AID - 10.1016/j.prp.2019.152441 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2019 Jul;215(7):152441. doi: 10.1016/j.prp.2019.152441. Epub 
      2019 May 6.