PMID- 31085862
OWN - NLM
STAT- MEDLINE
DCOM- 20190711
LR  - 20220408
IS  - 1998-4022 (Electronic)
IS  - 0028-3886 (Linking)
VI  - 67
IP  - 2
DP  - 2019 Mar-Apr
TI  - Health-related quality of life after surgery in supratentorial gliomas.
PG  - 467-475
LID - 10.4103/0028-3886.257998 [doi]
AB  - INTRODUCTION: With improvements in overall and progression-free survival in 
      gliomas, current focus in neurosurgical oncology has largely shifted to the issue 
      of quality of life (QOL) after treatment. There are not too many prospective 
      studies evaluating QOL in these patients. We prospectively analyzed the health 
      related quality of life (HRQOL) using the short form (SF) 36 questionnaire among 
      patients harbouring a supratentorial glioma who underwent surgery at a tertiary 
      care center in India. METHODS: HRQOL was evaluated prospectively in 103 patients, 
      between May 2016 and November 2017, at Sanjay Gandhi Postgraduate Institute of 
      Medical Sciences, Lucknow. Score improvements were evaluated in terms of the 
      smallest difference that a patient perceived to be clinically beneficial. The 
      responsiveness of scores was assessed as minimum clinically important difference 
      (MCID), effect size (ES) and relative efficiency. Cronbach's alpha co-efficient 
      was used to assess the reliability of the result obtained. RESULTS: The mean 
      pre-operative score was the highest in the mental health domain (50.21+/-21.45) and 
      significantly lower in patients with raised intracranial pressure (ICP), 
      pre-operative deficits, a poor Karnofsky performance scale (KPS) score, in large 
      tumors (>4cm) located in an eloquent location and in deep-seated tumors. A 
      significant improvement was noted across all domains except the physical role 
      (P-value 0.20). Overall, the general health domain was most responsive to change 
      with the largest t-value (6.56) and 55.7% patients achieved their target MCID in 
      general health (GH) domain. Among all the factors studied, only a low baseline 
      SF-36 score was significantly associated with a change in QOL after surgery. 
      CONCLUSION: Most parameters of HRQOL improved following surgery. Only 
      small-to-moderate improvements occured in the early follow-up period. Large 
      improving trends were noted on a long-term basis, irrespective of the 
      histo-pathological grade. Similar improvements were also noted in patients who 
      subsequently underwent re-surgery despite the development of post-operative 
      complications or new deficits. Also, a low baseline QOL score heralded a poor 
      survival.
FAU - Khatri, Deepak
AU  - Khatri D
AD  - Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical 
      Science (SGPGIMS), Lucknow, Uttar Pradesh, India.
FAU - Jaiswal, Awadhesh
AU  - Jaiswal A
AD  - Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical 
      Science (SGPGIMS), Lucknow, Uttar Pradesh, India.
FAU - Das, Kuntal K
AU  - Das KK
AD  - Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical 
      Science (SGPGIMS), Lucknow, Uttar Pradesh, India.
FAU - Pandey, Satyadeo
AU  - Pandey S
AD  - Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical 
      Science (SGPGIMS), Lucknow, Uttar Pradesh, India.
FAU - Bhaisora, Kamlesh
AU  - Bhaisora K
AD  - Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical 
      Science (SGPGIMS), Lucknow, Uttar Pradesh, India.
FAU - Kumar, Raj
AU  - Kumar R
AD  - Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical 
      Science (SGPGIMS), Lucknow, Uttar Pradesh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neurol India
JT  - Neurology India
JID - 0042005
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/*surgery
MH  - Female
MH  - Glioma/*surgery
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Glioma
OT  - life
OT  - post-operative
OT  - quality
OT  - supratentorial
COIS- None
EDAT- 2019/05/16 06:00
MHDA- 2019/07/12 06:00
CRDT- 2019/05/16 06:00
PHST- 2019/05/16 06:00 [entrez]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2019/07/12 06:00 [medline]
AID - ni_2019_67_2_467_257998 [pii]
AID - 10.4103/0028-3886.257998 [doi]
PST - ppublish
SO  - Neurol India. 2019 Mar-Apr;67(2):467-475. doi: 10.4103/0028-3886.257998.