PMID- 31086250
OWN - NLM
STAT- MEDLINE
DCOM- 20201104
LR  - 20210109
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 May 13
TI  - Effects of diaphragmatic myofascial release on gastroesophageal reflux disease: a 
      preliminary randomized controlled trial.
PG  - 7273
LID - 10.1038/s41598-019-43799-y [doi]
LID - 7273
AB  - The purpose of this study is to investigate whether implementing a myofascial 
      release (MFR) protocol designed to restore the myofascial properties of the 
      diaphragm has any effect on the symptoms, quality of life, and consumption of 
      proton pump inhibitors (PPI) drugs by patients with non-erosive gastroesophageal 
      reflux disease (GERD). We randomized 30 patients with GERD into a MFR group or a 
      sham group. Changes in symptomatology and quality of life were measured with the 
      Reflux Disease Questionnaire and the Gastrointestinal Quality of Life Index. Need 
      of PPIs was measured as the milligrams of drug intake over the 7 days prior to 
      each assessment. All variables were assessed at baseline, one week and 4 weeks 
      after the end of the treatment. At week 4, patients receiving MFR showed 
      significant improvements in symptomatology (mean difference-1.1; 95% CI: -1.7 to 
      -0.5), gastrointestinal quality of life (mean difference 18.1; 95% CI: 4.8 to 
      31.5), and PPIs use (mean difference-97 mg; 95% CI: -162 to -32), compared to the 
      sham group. These preliminary findings indicate that the application of the MFR 
      protocol we used in this study decreased the symptoms and PPIs usage and 
      increased the quality of life of patients with non-erosive GERD up to four weeks 
      after the end of the treatment.
FAU - Martinez-Hurtado, I
AU  - Martinez-Hurtado I
AD  - Department of Physiotherapy, Universidad Cardenal Herrera-CEU, CEU Universities, 
      Valencia, Spain.
FAU - Arguisuelas, M D
AU  - Arguisuelas MD
AD  - Department of Physiotherapy, Universidad Cardenal Herrera-CEU, CEU Universities, 
      Valencia, Spain.
FAU - Almela-Notari, P
AU  - Almela-Notari P
AD  - Department of Gastroenterology, Hospital General de Castellon, Castellon, Spain.
AD  - Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, 
      Valencia, Spain.
FAU - Cortes, X
AU  - Cortes X
AD  - Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, 
      Valencia, Spain.
AD  - Digestive Disease Department, Hospital of Sagunto, Valencia, Spain.
FAU - Barrasa-Shaw, A
AU  - Barrasa-Shaw A
AD  - Department of Surgery, Universidad Cardenal Herrera-CEU, CEU Universities, 
      Valencia, Spain.
AD  - Hospitales Vithas Nisa Virgen del Consuelo & 9 de Octubre, Valencia, Spain.
FAU - Campos-Gonzalez, J C
AU  - Campos-Gonzalez JC
AD  - Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, 
      Valencia, Spain.
AD  - Hospital Arnau de Vilanova, Valencia, Spain.
FAU - Lison, J F
AU  - Lison JF
AD  - Department of Medicine, Universidad Cardenal Herrera-CEU, CEU Universities, 
      Valencia, Spain. juanfran@uchceu.es.
AD  - CIBER of Physiopathology of Obesity and Nutrition CIBERobn, CB06/03 Carlos III 
      Health Institute, Madrid, Spain. juanfran@uchceu.es.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20190513
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - *Diaphragm
MH  - Female
MH  - Gastroesophageal Reflux/drug therapy/*therapy
MH  - Humans
MH  - Male
MH  - Massage/*methods
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Quality of Life
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
PMC - PMC6513998
COIS- The authors declare no competing interests.
EDAT- 2019/05/16 06:00
MHDA- 2020/11/05 06:00
PMCR- 2019/05/13
CRDT- 2019/05/16 06:00
PHST- 2019/01/28 00:00 [received]
PHST- 2019/04/29 00:00 [accepted]
PHST- 2019/05/16 06:00 [entrez]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2020/11/05 06:00 [medline]
PHST- 2019/05/13 00:00 [pmc-release]
AID - 10.1038/s41598-019-43799-y [pii]
AID - 43799 [pii]
AID - 10.1038/s41598-019-43799-y [doi]
PST - epublish
SO  - Sci Rep. 2019 May 13;9(1):7273. doi: 10.1038/s41598-019-43799-y.