PMID- 31087784
OWN - NLM
STAT- MEDLINE
DCOM- 20200108
LR  - 20200108
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 47
IP  - 9
DP  - 2019 Sep
TI  - Biomarkers to diagnose metastatic breast carcinoma to the pancreas: A case report 
      and update.
PG  - 912-917
LID - 10.1002/dc.24210 [doi]
AB  - The patient is a 72-year-old female who presents with new onset jaundice. The 
      patient has a past medical history significant for right-sided estrogen receptor 
      (ER)-positive and left-sided ER-negative breast cancers in 2005 and 2009, 
      respectively, and recent 1-year history of ER-positive right-sided breast cancer 
      with bone and brain metastases. CT scan and endoscopic ultrasound (EUS) revealed 
      a new 2 cm mass in the head of the pancreas, leading to EUS-guided fine-needle 
      aspiration of the lesion. Pathologic workup revealed adenocarcinoma with 
      signet-ring cells, representing either metastatic breast or primary pancreatic 
      cancer. Immunohistochemistry and molecular diagnostic workup identified positive 
      GATA-binding protein 3 (GATA3) immunoreactivity and a mutation in Erb-B2 receptor 
      tyrosine kinase 2 (ERBB2), also known as human epidermal growth factor receptor 2 
      (HER2). Here, we review the diagnostic markers commonly used to differentiate 
      metastatic breast vs primary pancreatic adenocarcinoma, and discuss the 
      challenges of utilizing GATA3 immunoreactivity and ERBB2 mutations for diagnosis.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Shee, Kevin
AU  - Shee K
AUID- ORCID: 0000-0001-5378-7650
AD  - Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
FAU - Strait, Alexander M
AU  - Strait AM
AUID- ORCID: 0000-0001-6213-0095
AD  - Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical 
      Center, Lebanon, New Hampshire.
FAU - Liu, Xiaoying
AU  - Liu X
AD  - Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical 
      Center, Lebanon, New Hampshire.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20190514
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*metabolism
MH  - *Biopsy, Fine-Needle
MH  - *Breast Neoplasms/diagnostic imaging/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Molecular Diagnostic Techniques
MH  - Neoplasm Metastasis
MH  - Neoplasm Proteins/*metabolism
MH  - Pancreatic Neoplasms/metabolism/pathology/secondary
MH  - *Tomography, X-Ray Computed
MH  - Ultrasonography
EDAT- 2019/05/16 06:00
MHDA- 2020/01/09 06:00
CRDT- 2019/05/16 06:00
PHST- 2019/03/28 00:00 [received]
PHST- 2019/04/22 00:00 [revised]
PHST- 2019/04/26 00:00 [accepted]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2020/01/09 06:00 [medline]
PHST- 2019/05/16 06:00 [entrez]
AID - 10.1002/dc.24210 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2019 Sep;47(9):912-917. doi: 10.1002/dc.24210. Epub 2019 May 
      14.