PMID- 31089284
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20220417
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 55
IP  - 1
DP  - 2020 Jan
TI  - Post-transplant cyclophosphamide use in matched HLA donors: a review of 
      literature and future application.
PG  - 40-47
LID - 10.1038/s41409-019-0547-8 [doi]
AB  - The last decade had witnessed a remarkable reduction in the incidence of acute 
      and chronic GvHD (graft versus host disease) in both related and unrelated 
      transplants mostly due to the improved resolution of HLA (human leukocyte 
      antigen) typing and the new methods for GvHD prevention. The use of 
      post-transplant cyclophosphamide (PTCY) to mitigate the bidirectional 
      alloreactivity in the setting of haploidentical transplant have revolutionized 
      and revived the field. Based on the promising results of PTCY in the 
      haploidentical transplant field many groups used the same strategy in the setting 
      of HLA-matched donors. This review will carefully examine the available data 
      about the use of PTCY in HLA-matched setting.
FAU - El Fakih, Riad
AU  - El Fakih R
AUID- ORCID: 0000-0003-4498-3865
AD  - Department of Adult Hematology & Stem Cell Transplant, King Faisal Hospital & 
      Research Center, Riyadh, KSA, Saudi Arabia. relfakih1@kfshrc.edu.sa.
FAU - Hashmi, Shahrukh K
AU  - Hashmi SK
AD  - Department of Adult Hematology & Stem Cell Transplant, King Faisal Hospital & 
      Research Center, Riyadh, KSA, Saudi Arabia. Shashmi@kfshrc.edu.sa.
AD  - Department of Medicine, Mayo Clinic, Rochester, MN, USA. Shashmi@kfshrc.edu.sa.
FAU - Ciurea, Stephen O
AU  - Ciurea SO
AD  - Department of Stem Cell Transplantation and Cellular Therapy, University of Texas 
      MDACC, Houston, TX, USA.
FAU - Luznik, Leo
AU  - Luznik L
AD  - Department of Oncology Hematologic Malignancies, Johns Hopkins University School 
      of Medicine, Baltimore, MD, USA.
FAU - Gale, Robert Peter
AU  - Gale RP
AD  - Hematology Research Centre, Division of Experimental Medicine, Department of 
      Medicine, Imperial College London, London, UK.
FAU - Aljurf, Mahmoud
AU  - Aljurf M
AD  - Department of Adult Hematology & Stem Cell Transplant, King Faisal Hospital & 
      Research Center, Riyadh, KSA, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190514
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Cyclophosphamide
MH  - *Graft vs Host Disease/prevention & control
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Tissue Donors
MH  - Transplantation, Haploidentical
MH  - Unrelated Donors
EDAT- 2019/05/16 06:00
MHDA- 2021/06/22 06:00
CRDT- 2019/05/16 06:00
PHST- 2019/02/07 00:00 [received]
PHST- 2019/04/06 00:00 [accepted]
PHST- 2019/03/19 00:00 [revised]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/05/16 06:00 [entrez]
AID - 10.1038/s41409-019-0547-8 [pii]
AID - 10.1038/s41409-019-0547-8 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2020 Jan;55(1):40-47. doi: 10.1038/s41409-019-0547-8. 
      Epub 2019 May 14.