PMID- 31090201
OWN - NLM
STAT- MEDLINE
DCOM- 20200129
LR  - 20221207
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 22
IP  - 8
DP  - 2019 Aug
TI  - Comparison of ankylosing spondylitis and non-radiographic axial spondyloarthritis 
      in a multi-ethnic Asian population of Singapore.
PG  - 1506-1511
LID - 10.1111/1756-185X.13603 [doi]
AB  - OBJECTIVES: To compare clinical characteristics, disease activity, 
      patient-reported outcomes and associated comorbidities between patients with 
      ankylosing spondylitis (AS) and non-radiographic axial spondyloarthitis 
      (nr-axSpA) in a multi-ethnic Asian population of Singapore. METHODS: We used data 
      from the PREcision medicine in SPONdyloarthritis for Better Outcomes and Disease 
      Remission (PRESPOND) registry in Singapore General Hospital. All patients 
      fulfilled 2009 Assessment in AS International Working Group classification 
      criteria for axial SpA (axSpA). Of these, all AS patients fulfilled the 1984 
      modified New York criteria. Baseline characteristics, medications, disease 
      activity, patient-reported outcomes and inflammatory markers were recorded using 
      standardized questionnaires. RESULTS: Two hundred and sixty-two axSpA patients 
      (82% Chinese, 79% male) were included. Mean age (SD) at diagnosis was 32.4 (13.1) 
      years, which was similar between AS and nr-axSpA patients. AS patients were older 
      (mean age 42.7 [13.5] vs 37.4 [13.8] years, P = 0.02), had longer disease 
      duration (mean disease duration 10.9 [8.7] vs 6.4 [4.8] years, P < 0.01), higher 
      Bath Ankylosing Spondylitis Metrology Index (BASMI) (mean BASMI 3.1 [2.3] vs 1.5 
      [1.5], P < 0.01), more frequently human leukocyte antigen (HLA)-B27 positive (82% 
      vs 68%, P = 0.03), associated with uveitis (33% vs 17%, P = 0.03), and 
      hypertensive (17% vs 0%, P < 0.01) compared to nr-axSpA, respectively. Nr-axSpA 
      patients had higher Bath Ankylosing Spondylitis Global Score (BAS-G) (mean BAS-G 
      46.9 [16.8] vs 38.6 [20.6], P < 0.01), Bath Ankylosing Spondylitis Disease 
      Activity Index (mean [SD] 4.2 [1.6] vs 3.5 [1.9], P = 0.02) and AS quality of 
      life (ASQoL) (mean ASQoL 4.9 [4.8] vs 3.5 [4.1], P = 0.04) scores compared to AS 
      patients respectively at baseline. Patient global assessment, Bath Ankylosing 
      Spondylitis Functional Index, AS Disease Activity Score - C-reactive protein 
      (CRP), Health Assessment Questionnaire, Short-Form 36 physical component summary 
      and mental component summary were similar in both groups at baseline, as were 
      medications used and mean erythrocyte sedimentation rate and CRP. CONCLUSIONS: In 
      our multi-ethnic Asian cohort, patients with AS are more likely to be HLA-B27 
      positive, have uveitis, hypertensive, and have poorer spinal mobility, while 
      nr-axSpA patients tend to experience poorer well-being and quality of life.
CI  - (c) 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Hong, Cassandra
AU  - Hong C
AD  - Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, 
      Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
FAU - Kwan, Yu Heng
AU  - Kwan YH
AD  - Program in Health Services and Systems Research, Duke-NUS Medical School, 
      Singapore, Singapore.
FAU - Leung, Ying-Ying
AU  - Leung YY
AUID- ORCID: 0000-0001-8492-6342
AD  - Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, 
      Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
FAU - Lui, Nai Lee
AU  - Lui NL
AD  - Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, 
      Singapore.
FAU - Fong, Warren
AU  - Fong W
AD  - Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, 
      Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190514
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - HLA-B27 Antigen/immunology
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Reported Outcome Measures
MH  - Quality of Life
MH  - Registries
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Singapore/epidemiology
MH  - *Spondylarthritis/diagnostic imaging/drug therapy/ethnology/immunology
MH  - *Spondylitis, Ankylosing/diagnostic imaging/drug therapy/ethnology/immunology
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - ankylosing spondylitis
OT  - axial spondyloarthritis
OT  - non-radiographic axial spondyloarthritis
OT  - spondyloarthritis
EDAT- 2019/05/16 06:00
MHDA- 2020/01/30 06:00
CRDT- 2019/05/16 06:00
PHST- 2018/09/18 00:00 [received]
PHST- 2019/04/12 00:00 [revised]
PHST- 2019/04/18 00:00 [accepted]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2020/01/30 06:00 [medline]
PHST- 2019/05/16 06:00 [entrez]
AID - 10.1111/1756-185X.13603 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2019 Aug;22(8):1506-1511. doi: 10.1111/1756-185X.13603. Epub 
      2019 May 14.