PMID- 31090636
OWN - NLM
STAT- MEDLINE
DCOM- 20200401
LR  - 20200511
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 24
IP  - 3
DP  - 2019 Jun
TI  - Nonhuman leukocyte antigen antibodies that have impact in the heart transplant 
      patient.
PG  - 279-285
LID - 10.1097/MOT.0000000000000642 [doi]
AB  - PURPOSE OF REVIEW: Despite human leukocyte antigen (HLA) matching and monitoring 
      for donor-specific HLA antibodies, antibody-mediated rejection and chronic 
      rejection in the form of allograft vasculopathy and chronic graft dysfunction 
      continue to occur. There has been increasing interest in non-HLA antibodies as 
      mediators of these changes. RECENT FINDINGS: In this review, we discuss the 
      recent literature describing the importance of non-HLA antibodies in organ 
      transplantation and summarize the literature evaluating such antibodies in heart 
      transplantation. SUMMARY: Monitoring of non-HLA antibodies requires additional 
      measurement standardization and correlation of specific antibodies with outcomes. 
      However, there is promise that identification with newer immunoproteomic 
      techniques and therapy toward such antibodies may improve long-term graft 
      outcomes and decrease acute rejection and allograft vasculopathy.
FAU - Reddy, Yogesh N V
AU  - Reddy YNV
AD  - The Department of Cardiovascular Medicine.
FAU - Pereira, Naveen L
AU  - Pereira NL
AD  - The Department of Cardiovascular Medicine.
AD  - Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 
      Rochester, Minnesota, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (HLA Antigens)
SB  - IM
MH  - HLA Antigens/*immunology
MH  - Heart Transplantation/*methods
MH  - Humans
EDAT- 2019/05/16 06:00
MHDA- 2020/04/02 06:00
CRDT- 2019/05/16 06:00
PHST- 2019/05/16 06:00 [entrez]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2020/04/02 06:00 [medline]
AID - 00075200-201906000-00012 [pii]
AID - 10.1097/MOT.0000000000000642 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2019 Jun;24(3):279-285. doi: 
      10.1097/MOT.0000000000000642.