PMID- 31091048
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 2308-1430 (Electronic)
IS  - 0375-9660 (Linking)
VI  - 65
IP  - 1
DP  - 2019 May 14
TI  - [Association of adiponectin gene alleles with type 2 diabetes mellitus in 
      residents of Bashkortostan].
PG  - 31-38
LID - 10.14341/probl9426 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is one of the most acute problems of the modern 
      world. The disease is characterized by high ratio of micro- and macrovascular 
      complications. T2DM is a multifactorial and polygenic disease, structure of 
      hereditary predisposition to which may be population-specific. Aim - the analysis 
      of allelic associations of adiponectin gene (ADIPOQ, rs17366743) with T2DM, its 
      clinical and metabolic characteristics and complications in T2DM patients 
      resident in the Republic of Bashkortostan. MATERIAL AND METHODS: 3 PCR-based 
      method of genotyping with polymorphic marker rs17366743 of ADIPOQ gene in 433 
      T2DM patients and 428 healthy controls, residents of Bashkortostan. RESULTS: The 
      ratio of genotype CT and allele capital ES, Cyrillic was higher in T2DM patients compared with 
      controls (15.7% vs. 6.8%; p=0.0002 and 7.8% vs. 3.4%; p<0.0001, respectively). 
      Genotype capital TE, Cyrilliccapital TE, Cyrillic and allele capital TE, Cyrillic were less frequent in T2DM than in healthy subjects 
      (84.3 and 93,2%; p=0.0002; 92.2 and 96.6%, p<0.0001, respectively). The 
      association with the development of diabetic retinopathy and cataract was shown 
      (p=0,044, p=0,008, respectively). CONCLUSIONS: Allele C and genotype CT are risk 
      markers of T2DM (OR=2.43 and 2.56 respectively).
FAU - Avzaletdinova, D S
AU  - Avzaletdinova DS
AUID- ORCID: 0000-0002-1590-6433
AD  - Bashkir State Medical University.
FAU - Sharipova, L F
AU  - Sharipova LF
AUID- ORCID: 0000-0003-4866-0983
AD  - Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian 
      Academy of Sciences.
FAU - Kochetova, O V
AU  - Kochetova OV
AUID- ORCID: 0000-0003-2071-0969
AD  - Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian 
      Academy of Sciences.
FAU - Morugova, T V
AU  - Morugova TV
AUID- ORCID: 0000-0001-7405-486X
AD  - Bashkir State Medical University.
FAU - Mustafina, O E
AU  - Mustafina OE
AUID- ORCID: 0000-0002-5118-6533
AD  - Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian 
      Academy of Sciences.
LA  - rus
PT  - Journal Article
DEP - 20190514
PL  - Russia (Federation)
TA  - Probl Endokrinol (Mosk)
JT  - Problemy endokrinologii
JID - 0140673
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/*genetics
MH  - Adult
MH  - Alleles
MH  - Bashkiria
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - adiponectin gene ADIPOQ
OT  - diabetes mellitus type 2
OT  - polymerase chain reaction
OT  - rs17366743 polymorphism
EDAT- 2019/05/16 06:00
MHDA- 2020/02/11 06:00
CRDT- 2019/05/16 06:00
PHST- 2017/10/31 00:00 [received]
PHST- 2018/11/01 00:00 [accepted]
PHST- 2018/07/09 00:00 [revised]
PHST- 2019/05/16 06:00 [entrez]
PHST- 2019/05/16 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
AID - 10.14341/probl9426 [doi]
PST - epublish
SO  - Probl Endokrinol (Mosk). 2019 May 14;65(1):31-38. doi: 10.14341/probl9426.