PMID- 31091348 OWN - NLM STAT- MEDLINE DCOM- 20200416 LR - 20200416 IS - 1521-6551 (Electronic) IS - 1521-6543 (Linking) VI - 71 IP - 7 DP - 2019 Jul TI - Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway. PG - 1041-1047 LID - 10.1002/iub.2066 [doi] AB - For the development of renal diseases, oxidative stress (OS) is reasoned to be one of the risk factors. For the treatment or prevention of the renal disease, the use of antioxidants could be a hopeful therapeutic mediation as they retard or block the oxidative reaction along with the inflammatory process. Luteolin (Lut) is a plant flavonoid, a pharmacologically active component normally found in glycosylated forms in basic perilla leaf, green pepper, celery, seed, honeysuckle bloom, and chamomile blossom; it exhibits antioxidant activity. In this investigation, we explored the nephroprotective activity of Lut on bisphenol A (BPA)-induced nephron toxicity in rats. Orally administering Lut (100 and 200 mg/kg) diminished BPA-induced anomalies in the kidney, blood urea nitrogen, creatinine, and serum uric acid levels. Lut therapy reduced the BPA-influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. This was coupled with significant improvement in kidney histopathologic features. Lut enhanced the nuclear factor-like 2 (Nrf2) and heme oxygenase 1 (HO-1) expression, which showed protection against OS induced by BPA. The current outcomes of the study showed that Lut has a strong reactive oxygen species scavenging property and potentially decreases the lipid peroxidation as well as inhibits DNA damage in renal toxicity induced by BPA. In conclusion, the potential antioxidant effect of Lut may be because of its modulatory effect on the Nrf2/antioxidant response element (ARE)/HO-1 pathway, which means it protects the kidney from BPA-induced oxidative injury. (c) 2019 IUBMB Life, 2019. CI - (c) 2019 International Union of Biochemistry and Molecular Biology. FAU - Alekhya Sita, Gadamsetty Jaya AU - Alekhya Sita GJ AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Gowthami, Motati AU - Gowthami M AUID- ORCID: 0000-0001-7185-2137 AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Srikanth, Gadiparthi AU - Srikanth G AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Krishna, M Murali AU - Krishna MM AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Rama Sireesha, Kokkiligadda AU - Rama Sireesha K AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Sajjarao, Mounika AU - Sajjarao M AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Nagarjuna, Kandru AU - Nagarjuna K AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Nagarjuna, Mukkamulla AU - Nagarjuna M AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Chinnaboina, Gopala Krishna AU - Chinnaboina GK AD - AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India. FAU - Mishra, Anurag AU - Mishra A AD - School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India. FAU - SreeHarsha, Nagaraja AU - SreeHarsha N AD - Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20190515 PL - England TA - IUBMB Life JT - IUBMB life JID - 100888706 RN - 0 (Antioxidants) RN - 0 (Benzhydryl Compounds) RN - 0 (Biomarkers) RN - 0 (Cytokines) RN - 0 (Free Radical Scavengers) RN - 0 (NF-E2-Related Factor 2) RN - 0 (Nfe2l2 protein, rat) RN - 0 (Phenols) RN - 0 (Protective Agents) RN - EC 1.14.14.18 (Heme Oxygenase (Decyclizing)) RN - EC 1.14.14.18 (Hmox1 protein, rat) RN - KUX1ZNC9J2 (Luteolin) RN - MLT3645I99 (bisphenol A) SB - IM MH - Animals MH - Antioxidant Response Elements/*genetics MH - Antioxidants/pharmacology MH - Benzhydryl Compounds/toxicity MH - Biomarkers/metabolism MH - Cytokines/metabolism MH - Free Radical Scavengers/toxicity MH - Gene Expression Regulation/drug effects MH - Heme Oxygenase (Decyclizing)/genetics/*metabolism MH - Inflammation/*drug therapy/metabolism/pathology MH - Kidney Diseases/chemically induced/metabolism/pathology/*prevention & control MH - Lipid Peroxidation/drug effects MH - Luteolin/*pharmacology MH - Male MH - NF-E2-Related Factor 2/genetics/*metabolism MH - Oxidative Stress/*drug effects MH - Phenols/toxicity MH - Protective Agents/*pharmacology MH - Rats MH - Rats, Wistar MH - Signal Transduction/drug effects OTO - NOTNLM OT - anti-inflammatory OT - antioxidant OT - bisphenol A OT - luteolin OT - nephrotoxicity EDAT- 2019/05/16 06:00 MHDA- 2020/04/17 06:00 CRDT- 2019/05/16 06:00 PHST- 2019/03/26 00:00 [received] PHST- 2019/04/24 00:00 [accepted] PHST- 2019/05/16 06:00 [pubmed] PHST- 2020/04/17 06:00 [medline] PHST- 2019/05/16 06:00 [entrez] AID - 10.1002/iub.2066 [doi] PST - ppublish SO - IUBMB Life. 2019 Jul;71(7):1041-1047. doi: 10.1002/iub.2066. Epub 2019 May 15.