PMID- 31092755
OWN - NLM
STAT- MEDLINE
DCOM- 20190813
LR  - 20190813
IS  - 0015-5691 (Print)
IS  - 0015-5691 (Linking)
VI  - 153
IP  - 5
DP  - 2019
TI  - [Physiological centers of decision-making: manipulation of neural activity in 
      insular cortex by AAV].
PG  - 224-230
LID - 10.1254/fpj.153.224 [doi]
AB  - Decision-making is a key activity process that influences many aspects of daily 
      living and both mental and physical health. In general, healthy participants 
      reveal rational choice, but patients with neuropsychiatric disorders reveal 
      irrational and risky choice in decision-making. Addiction is one of typical 
      diseases revealed risky decision-making, addicts select risky action and options 
      that confer short-term rewards at the cost of long-term disadvantages. Thus, 
      irrational and risky decision-making is recognized as a core problem in patients 
      with neuropsychiatric disorders, and a better understanding of the mechanisms 
      underlying altered decision-making would provide insights into potential 
      therapeutic approaches for these diseases. However, the neural pathway and 
      substrates underlying these deficits are particularly unknown. Recently, we found 
      that insular cortex is one of key regions for risky decision-making in an animal 
      model of methamphetamine addiction, by using the designer receptor exclusively 
      activated by designer drug (DREADD) technology, and that GABAergic dysfunction in 
      insular cortex is involved in evaluating the subjective value of reward and 
      reward prediction error. These brain dysfunctions would be related to risk taking 
      behavior in addiction. In this review, we introduced the possible neural pathway 
      related to risky decision-making and behavioral changes in choice strategy using 
      adeno associated virus (AAV).
FAU - Mizoguchi, Hiroyuki
AU  - Mizoguchi H
AD  - Research Center for Next-Generation Drug Development, Research Institute of 
      Environmental Medicine, Nagoya University.
FAU - Yamada, Kiyofumi
AU  - Yamada K
AD  - Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University 
      Graduate School of Medicine.
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Yakurigaku Zasshi
JT  - Nihon yakurigaku zasshi. Folia pharmacologica Japonica
JID - 0420550
RN  - 44RAL3456C (Methamphetamine)
MH  - Animals
MH  - Cerebral Cortex/*physiology
MH  - *Decision Making
MH  - Dependovirus
MH  - GABAergic Neurons/cytology
MH  - Humans
MH  - Methamphetamine/*pharmacology
MH  - Reward
MH  - *Risk-Taking
EDAT- 2019/05/17 06:00
MHDA- 2019/08/14 06:00
CRDT- 2019/05/17 06:00
PHST- 2019/05/17 06:00 [entrez]
PHST- 2019/05/17 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
AID - 10.1254/fpj.153.224 [doi]
PST - ppublish
SO  - Nihon Yakurigaku Zasshi. 2019;153(5):224-230. doi: 10.1254/fpj.153.224.