PMID- 31092767
OWN - NLM
STAT- MEDLINE
DCOM- 20200214
LR  - 20200214
IS  - 1881-7122 (Electronic)
IS  - 1341-1357 (Print)
IS  - 0007-5124 (Linking)
VI  - 68
IP  - 4
DP  - 2019 Nov 6
TI  - Neuron-specific Mafb knockout causes growth retardation accompanied by an 
      impaired growth hormone/insulin-like growth factor I axis.
PG  - 435-442
LID - 10.1538/expanim.18-0182 [doi]
AB  - Mammalian postnatal growth is regulated primarily by the growth hormone 
      (GH)/insulin-like growth factor I (IGF-I) axis. MafB is a basic leucine zipper 
      (bZip) transcription factor that has pleiotropic functions. Although MafB plays a 
      critical role in fetal brain development, such as in guidance for hindbrain 
      segmentation, its postnatal role in neurons remains to be elucidated. To 
      investigate this, we used neuron-specific Mafb conditional knockout (cKO) mice. 
      In addition to an approximately 50% neonatal viability, the Mafb cKO mice 
      exhibited growth retardation without apparent signs of low energy intake. 
      Notably, serum IGF-I levels of these mice in the postnatal stage were lower than 
      those of control mice. They seemed to have a neuroendocrine dysregulation, as 
      shown by the upregulation of serum GH levels in the resting state and an 
      inconsistent secretory response of GH upon administration of growth 
      hormone-releasing hormone. These findings reveal that neuronal MafB plays an 
      important role in postnatal development regulated by the GH/IGF-I axis.
FAU - Maimaiti, Shayida
AU  - Maimaiti S
AD  - Department of Anatomy and Embryology, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8575, Japan.
AD  - Present address: Okinawa Institute of Science and Technology Graduate University, 
      1919-1 Tancha, Onna-son, Okinawa 904-0412, Japan.
FAU - Koshida, Ryusuke
AU  - Koshida R
AD  - Department of Anatomy and Neuroscience, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8577, Japan.
FAU - Ojima, Masami
AU  - Ojima M
AD  - Department of Anatomy and Embryology, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8575, Japan.
FAU - Kulathunga, Kaushalya
AU  - Kulathunga K
AD  - Department of Anatomy and Embryology, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8575, Japan.
AD  - Ph.D. Program in Human Biology, School of Integrative and Global Majors, 
      University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
FAU - Oishi, Hisashi
AU  - Oishi H
AD  - Department of Comparative and Experimental Medicine, Nagoya City University, 1 
      Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
FAU - Takahashi, Satoru
AU  - Takahashi S
AD  - Department of Anatomy and Embryology, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8575, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190516
PL  - Japan
TA  - Exp Anim
JT  - Experimental animals
JID - 9604830
RN  - 0 (MafB Transcription Factor)
RN  - 0 (Mafb protein, mouse)
RN  - 0 (insulin-like growth factor-1, mouse)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Animals
MH  - Female
MH  - Gene Knockout Techniques
MH  - Growth Disorders/*genetics
MH  - Growth Hormone/*metabolism
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - MafB Transcription Factor/*genetics/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Knockout
PMC - PMC6842794
OTO - NOTNLM
OT  - MafB
OT  - growth hormone
OT  - growth retardation
OT  - insulin-like growth factor I
OT  - nutritional status
EDAT- 2019/05/17 06:00
MHDA- 2020/02/15 06:00
PMCR- 2019/01/01
CRDT- 2019/05/17 06:00
PHST- 2019/05/17 06:00 [pubmed]
PHST- 2020/02/15 06:00 [medline]
PHST- 2019/05/17 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 18-0182 [pii]
AID - 10.1538/expanim.18-0182 [doi]
PST - ppublish
SO  - Exp Anim. 2019 Nov 6;68(4):435-442. doi: 10.1538/expanim.18-0182. Epub 2019 May 
      16.