PMID- 31092771
OWN - NLM
STAT- MEDLINE
DCOM- 20190627
LR  - 20200225
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 58
IP  - 10
DP  - 2019
TI  - A Study of the Vascular Endothelial Function in Patients with Type 2 Diabetes 
      Mellitus and Rheumatoid Arthritis.
PG  - 1383-1390
LID - 10.2169/internalmedicine.1564-18 [doi]
AB  - Objective Type 2 diabetes mellitus (T2DM) and rheumatoid arthritis (RA) are both 
      complicated by arteriosclerosis, resulting in increased rates of cardiovascular 
      events. No previous studies have compared the index between RA and T2DM. We 
      assessed the vascular endothelial function in early-stage arteriosclerosis for 
      each disease to determine the influential factors and compared the extent to 
      which these two diseases cause vascular endothelial dysfunction. Methods This 
      study is a retrospective study based on medical records. Differences in the 
      reactive hyperemia index (RHI) among the groups and factors affecting the RHI in 
      each group was analyzed. The vascular endothelial function was assessed by 
      measuring the RHI using peripheral arterial tonometry. Patients The study 
      subjects were 114 patients with non-functional thyroid tumors (healthy n=14), 
      T2DM (T2DM n=64), and RA (RA n=36). Results The RHI was 2.29 in the control, 1.85 
      in the T2DM, and 1.83 in the RA group, with values lower in the T2DM and RA 
      groups than in the control group (p=0.033) but not markedly different between the 
      two disease groups. The RHI distribution (<1.68/1.68 to <2.10/>/=2.1) was as 
      follows: control group: 14.3%/28.6%/57.1%; T2DM group: 42.2%/39.1%/18.8%; and RA 
      group: 36.1%/44.4%/19.4% (p=0.031), respectively. A multivariate analysis 
      identified the triglyceride level and dyslipidemia in the control group and the 
      Disease Activity Score in 28 joints with the erythrocyte sedimentation rate and 
      fasting plasma glucose level in the RA group to influence the RHI. Conclusion The 
      vascular endothelial function was impaired in approximately 80% of patients with 
      T2DM and RA, with comparable degrees of impairment between the two diseases. No 
      factors affecting the function were identified in the T2DM group, while the 
      function was more impaired in patients with a higher disease activity in the RA 
      group.
FAU - Mori, Hiroko
AU  - Mori H
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Okada, Yosuke
AU  - Okada Y
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Kawaguchi, Mayuko
AU  - Kawaguchi M
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Iwata, Shigeru
AU  - Iwata S
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Yoshikawa, Maiko
AU  - Yoshikawa M
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Sonoda, Satomi
AU  - Sonoda S
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Sugai, Kei
AU  - Sugai K
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Tanaka, Kenichi
AU  - Tanaka K
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Hajime, Maiko
AU  - Hajime M
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Narisawa, Manabu
AU  - Narisawa M
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
FAU - Tanaka, Yoshiya
AU  - Tanaka Y
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190515
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arteriosclerosis/*physiopathology
MH  - Arthritis, Rheumatoid/*physiopathology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Hyperemia/*physiopathology
MH  - Male
MH  - Manometry/methods
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC6548912
OTO - NOTNLM
OT  - Endo-PAT
OT  - reactive hyperemia index
OT  - rheumatoid arthritis
OT  - type 2 diabetes
COIS- Author's disclosure of potential Conflicts of Interest (COI). Yosuke Okada: 
      Honoraria, MSD, Astellas, Mitsubishi-Tanabe, Eli Lilly, Takeda, Ono, Novo and 
      Bayer; Research funding, Mitsubishi-Tanabe and Kowa. Yoshiya Tanaka: Honoraria, 
      Daiichi-Sankyo, Astellas, Pfizer, Mitsubishi-Tanabe, Bristol-Myers, Chugai, YL 
      Biologics, Eli Lilly, Sanofi, Janssen and UCB; Research funding, 
      Mitsubishi-Tanabe, Takeda, Bristol-Myers, Chugai, Astellas, Abbvie, MSD, 
      Daiichi-Sankyo, Pfizer, Kyowa-Kirin, Eisai and Ono.
EDAT- 2019/05/17 06:00
MHDA- 2019/06/30 06:00
PMCR- 2019/05/15
CRDT- 2019/05/17 06:00
PHST- 2019/05/17 06:00 [entrez]
PHST- 2019/05/17 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2019/05/15 00:00 [pmc-release]
AID - 10.2169/internalmedicine.1564-18 [doi]
PST - ppublish
SO  - Intern Med. 2019;58(10):1383-1390. doi: 10.2169/internalmedicine.1564-18. Epub 
      2019 May 15.